HUBUNGAN ANTARA BEBERAPA PARAMETER ANEMIA DAN LAJU FILTRASI GLOMERULUS PADA PENYAKIT GINJAL KRONIK PRADIALISIS

Abstract

Anemia is one of chronic kidney disease (CKD) complication and it affects many organs including cardiovascular. Early
detection and evaluation are important to prevent more serious complications. There is scarce data with regard about correlation
between anemia and glomerulus ltration rate (GFR) in pradialysis CKD.
Aim of this study is to determine correlation between anemia parameters and GFR, also prevalence of anemia in pradialysis
CKD in Sanglah Hospital, Denpasar-Bali. An analytical cross sectional study was carried out in Sanglah Hospital. Samples were
selected through simple random sampling.
Eighty samples (58 males and 22 females, aged 54 ± 10 years) were included. Prevalence of anemia, serum iron below
than 50 ug/dl, transferrin saturation below than 20% and erythropoietin below than 5 mIU/ml was 41.3%, 25%, 20%, and 25%
respectively. Using Pearson?s analysis, there were signicant correlation between haemoglobin (r = 0.76, p = 0.00) and serum
iron (r = 0.29, p = 0.01) with LFG. Using linier regression entering those variables into model, it found formula haemoglobin
= 7.63 + 0.13GFR (R-square = 0.58, p = 0.00) and serum iron = 54.71 + 0.48GFR (R-square = 0.08, p = 0.01). There was
signicant correlation between haemoglobin and serum iron with LFG. Forty one percent pradialysis CKD patients had anemia
complication.