POTENSI TOKSISITAS NEUROLOGIS VINKRISTIN PADA TUBUH YANG TERJADI PADA ANAK DENGAN LEUKEMIA LIMFOSITIK AKUT

  • Ni Made Intan Pertiwi
  • Ketut Ariawati
  • Rasmaya Niruri
  • Rini Noviyani
  • A.A. Raka Karsana
  • Mahardika Aprilia Iflahah

Abstract

Acute Lymphoblastic Leukemia (ALL) treatment are chemotherapeutic agent and bone marrow transplantation. Treatment with chemotherapeutic agent is the primary curative for leukemia. Vincristine is one of chemotherapeutic agents in ALL. Neurotoxicity is one of the toxicity caused by vincristine. The objective of this study was to find out the potential neurotoxicity of vincristine in children with ALL. Method: This study was observational design. The study was conducted at Sanglah Hospital Denpasar. Patient data was collected from May 2011- March 2013 period. Result: Seventeen patients who fit to the sample criteria were got. Of the 17 childhood with ALL who have treatment with chemotherapeutic agent based on Indonesian Protocol 2006, 3 patients showed neurotoxicity. Patients may suffered from leg pain, foot pain, and walking pain. Conclusion: There are potential neurotoxicity vincristine in children with ALL who have treatment with chemotherapeutic agent. Potential neurotoxicity can be caused by mechanism of action vincristine in microtubules.

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Author Biographies

Ni Made Intan Pertiwi
Jurusan Farmasi FMIPA Universitas Udayana, Bukit Jimbaran
Ketut Ariawati
Bagian/SMF IKA FK Unud-Rumah Sakit Umum Pusat Sanglah
Rasmaya Niruri
Jurusan Farmasi FMIPA Universitas Udayana, Bukit Jimbaran
Rini Noviyani
Jurusan Farmasi FMIPA Universitas Udayana, Bukit Jimbaran
A.A. Raka Karsana
Instalasi Farmasi, Rumah Sakit Umum Pusat Sanglah
Mahardika Aprilia Iflahah
Jurusan Kimia FMIPA Universitas Udayana, Kampus Bukit Jimbaran
Published
2013-07-01
How to Cite
INTAN PERTIWI, Ni Made et al. POTENSI TOKSISITAS NEUROLOGIS VINKRISTIN PADA TUBUH YANG TERJADI PADA ANAK DENGAN LEUKEMIA LIMFOSITIK AKUT. Jurnal Kimia (Journal of Chemistry), [S.l.], july 2013. ISSN 2599-2740. Available at: <https://ojs.unud.ac.id/index.php/jchem/article/view/8232>. Date accessed: 29 may 2020. doi: https://doi.org/10.24843/JCHEM.2013.v07.i02.p10.
Section
Articles

Keywords

Potential neurotoxicity, vincristine, leukemia