PENURUNAN FUNGSI HATI TIKUS BETINA (Rattus norvegivus L) YANG DIINJEKSI WHITE VITAMIN C DOSIS TINGGI DALAM JANGKA WAKTU LAMA DITINJAU DARI KADAR SGPT, SGOT SERTA GAMBARAN HISTOLOGI HATI

  • Ni Wayan Sudatri
  • Iriani Setyawati
  • Ni Made Suartini
  • Dwi Ariani Yulihastuti
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Abstrak

This study aims to determine the side effects of high-dose injections of vitamin C in a long term against liver histology. This study used a completely randomized design (CRD) with different long treatments of vitamin C injection in various doses of P0 (control), P1 (30 days injection), P2 (50 days injection), P3 (70 days injection) and P4 (90 days injection). Parameters measured were plasma levels of SGPT and SGOT, the percentage of hydropic degeneration,  fatty degeneration, pyknotik nuclei, and necrosis of liver cells, and also inflammatory cell infiltration and sinusoid congestion. SGOT levels showed a significant differences (P=0,009) between the treatment and control group by ANOVA test. The Kruskal Wallis test showed that ALT levels were not significantly different (P=0,86), however, the levels of creatinine showed significant differences (P=0,002). The hydropic degeneration were not significantly different (P=0,054) by Kruskal Wallis test, whereas the fatty degeneration were significantly different (P=0,000) between the treatment and control groups by ANOVA test. Pyknotik nuclei and necrotic cells showed significant differences between the control and treatment with the P value of 0,016 and 0,01 respetively. The injected white vitamin C in high doses for long periods decreased the physiological functions of female mice liver.

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##submission.authorBiographies##

Ni Wayan Sudatri

Jurusan Biologi, Fakultas MIPA, Universitas Udayana, Bukit Jimbaran, Badung, Bali

Iriani Setyawati

Jurusan Biologi, Fakultas MIPA, Universitas Udayana, Bukit Jimbaran, Badung, Bali

Ni Made Suartini
Jurusan Biologi, Fakultas MIPA, Universitas Udayana, Bukit Jimbaran, Badung, Bali
Dwi Ariani Yulihastuti
Jurusan Biologi, Fakultas MIPA, Universitas Udayana, Bukit Jimbaran, Badung, Bali
Diterbitkan
2016-03-14
##submission.howToCite##
SUDATRI, Ni Wayan et al. PENURUNAN FUNGSI HATI TIKUS BETINA (Rattus norvegivus L) YANG DIINJEKSI WHITE VITAMIN C DOSIS TINGGI DALAM JANGKA WAKTU LAMA DITINJAU DARI KADAR SGPT, SGOT SERTA GAMBARAN HISTOLOGI HATI. Metamorfosa: Journal of Biological Sciences, [S.l.], v. 3, n. 1, p. 44-51, mar. 2016. ISSN 2655-8122. Tersedia pada: <https://ojs.unud.ac.id/index.php/metamorfosa/article/view/19346>. Tanggal Akses: 14 oct. 2025 doi: https://doi.org/10.24843/metamorfosa.2016.v03.i01.p07.
Bagian
English

Kata Kunci

liver histology, SGPT, SGOT, white vitamin C, the female rats

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