PENENTUAN KADAR 8-HIDROKSI-2’-DEOKSIGUANOSIN (8-OHdG) DALAM URIN TIKUS SETELAH TERPAPAR ETANOL DAN ASAP ROKOK
Abstract
Urinary level of 8-OHdG in rats after exposure to ethanol and smoke have been investigated for 15 days with TLC-Spectrophotodensitometer. Ethanol and smoke exposure to could increase the number of Reactive Oxygen Species (ROS), which could lead to a state called oxidative stress. 8-OHdG compound is the result of DNA oxidation by ROS in the body in the form of guanine nucleotide. This 8-OHdG is a water-soluble compound excreted in urine easily. In this study, exposure of ethanol and smoke both singly and combined had an effect on the level of 8-OHdG. Urinary level of 8-OHdG in the control group; groups exposed to ethanol, smoke, and ethanol-smoke were (0,00 ± 0,00)%, (0,33 ± 0,08)%, (0,25 ± 0,10)%, and (0,57 ± 0,27)% respectively.Downloads
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Published
2014-01-01
How to Cite
IFLAHAH, Mahardika Aprilia; SUANITI, Ni Made; RAKA ASTITI ASIH, Ida Ayu.
PENENTUAN KADAR 8-HIDROKSI-2’-DEOKSIGUANOSIN (8-OHdG) DALAM URIN TIKUS SETELAH TERPAPAR ETANOL DAN ASAP ROKOK.
Jurnal Kimia (Journal of Chemistry), [S.l.], jan. 2014.
ISSN 2599-2740.
Available at: <https://ojs.unud.ac.id/index.php/jchem/article/view/9744>. Date accessed: 01 sep. 2024.
doi: https://doi.org/10.24843/JCHEM.2014.v08.i01.p07.
Section
Articles
Keywords
Ethanol, Smoke, ROS, 8-OHdG, TLC-Spectrophotodensitometer
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