IN VIVO ANTI-INFLAMMATORY ACTIVITY OF DADAP LEAVES (Erythrina subumbrans (Hassk.) Merr)

  • Ni Luh Kade Arman Anita Dewi Faculty of Pharmacy, Mahasaraswati University
  • Ni Luh Sintya Faculty of Pharmacy, Mahasaraswati University
  • Maria Malida Vernandes Sasadara Faculty of Pharmacy, Mahasaraswati University
  • Erna Cahyaningsih Faculty of Pharmacy, Mahasaraswati University
  • Putu Era Sandhi Kusuma Yuda Faculty of Pharmacy, Mahasaraswati University
  • Puguh Santoso Faculty of Pharmacy, Mahasaraswati University

Abstract

Leguminosae is widely known for its anti-inflammatory properties due to the presence of several beneficial phytochemicals, including alkaloids, flavonoids, steroids, and saponins. Dadap (Erythrina subumbrans (Hassk.) Merr), a Leguminosae member, has empirically been used to treat inflammation. This research aimed to prove the anti-inflammatory effect of Dadap leaves scientifically. Dadap leaves were macerated in 96% ethanol to produced crude ethanol extract, followed by in vivo anti-inflammatory assay with the paw edema method. Three different doses of extract: 200, 300, and 400mg/kg BW, were administrated to Wistar rats to observed its ability in reducing carrageenan-induced inflammatory. All extract doses produced similar anti-inflammatory activity as compared to diclofenac sodium as a positive control. There is no significant difference among the three different doses. The results indicated that all treatment doses produced anti-inflammatory activity, but 200mg/kg BW administration was most efficient.

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Published
2021-09-30
How to Cite
DEWI, Ni Luh Kade Arman Anita et al. IN VIVO ANTI-INFLAMMATORY ACTIVITY OF DADAP LEAVES (Erythrina subumbrans (Hassk.) Merr). International Journal of Biosciences and Biotechnology, [S.l.], v. 9, n. 1, p. 24 - 31, sep. 2021. ISSN 2655-9994. Available at: <https://ojs.unud.ac.id/index.php/jbb/article/view/78198>. Date accessed: 24 nov. 2024. doi: https://doi.org/10.24843/IJBB.2021.v09.i01.p03.