NEBIVOLOL: A THIRD GENERATION BETA BLOCKER AS ANTIHYPERTENSION AGENT

  • Ni Putu Wirantari
  • I Made Jawi
  • Bagus Komang Satriyasa

Abstract

Hypertension is a silent killer because it causes complications in vital organs unwitting patients. Beta blockers are generally a choice of safe and effective drugs for initial treatment of hypertension. However, the current hypertension treatment guidelines said beta blockers were not suitable use as first-line therapy because of complications caused. On the use of atenolol found an increased incidence of cardiovascular death of 24%, 14% and cardiac complications 23% cerebrovascular complications. Nebivolol is a third-generation beta-blocker that is highly selective for ?1-adrenergic receptors and has the ability as a direct vasodilator was able to stimulate the activity of endothelial L-arginin/nitric oxide synthase, is expected nebivolol can reduce blood pressure so can achieve blood pressure that expected.

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Author Biographies

Ni Putu Wirantari

Mahasiswa Fakultas Kedokteran Universitas Udayana

I Made Jawi

Bagian Farmakologi Fakultas Kedokteran Universitas Udayana

Bagus Komang Satriyasa
Bagian Farmakologi Fakultas Kedokteran Universitas Udayana
How to Cite
WIRANTARI, Ni Putu; JAWI, I Made; SATRIYASA, Bagus Komang. NEBIVOLOL: A THIRD GENERATION BETA BLOCKER AS ANTIHYPERTENSION AGENT. E-Jurnal Medika Udayana, [S.l.], p. 1244-1252, july 2013. ISSN 2303-1395. Available at: <https://ojs.unud.ac.id/index.php/eum/article/view/5816>. Date accessed: 13 aug. 2020.

Keywords

nebivolol, beta blocker, hypertension

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