HISTOLOGI HATI MENCIT (Mus musculus L.) YANG DIBERI EKSTRAK DAUN LAMTORO (Leucaena leucocephala)

Abstract

Leucaena (Leucaena leucocephala) has been used as traditional medicine, such as
drugs to decrease the level of blood glucose, so it can be used as drug to indicate
diabetes. The aim of this research is to study the histopathological change of mice’s liver
given leucaena leaf extract. This research used 24 male mice that were divided into 4 groups
by completely randomized design. Group P0 (control) were given 0,9 % NaCl, and groups
P1, P2, and P3 were given 0,5 g / kg bw, 1 g / kg bw, and 1,5 g / kg bw leucaena’s leaf
extract by oral administration respectively. The treatment were given daily for 30 days. All of
the mice were necropsied at day 31, and the liver were taken to examine their
histopathological change. Histopathological change examination were based on the present
hydropic degeneration, fatty degeneration, and apoptosis surround central vein. Result of
statistically analised by ANOVA and Kruskal-Wallis method indicated no significance
difference among the control and treatments. There was no significance toxicity effect of
leucaena leaf extract of all treatment dosage on mice liver.
Keywords: Leucaena leucocephala, liver histology, Mus musculus L.