The THE EFFECTIVENESS OF MORINGA LEAF TEA ON MALE WHITE RATS TO REDUCE CHOLESTEROL LEVELS
Abstract
Moringa has many benefits because it contains several active substances that are useful for health. This study aims to determine the benefits of Moringa leaf tea to lower cholesterol in male white rats. The research method was RAK with four treatment groups. The control group (K0), group 1 (K1) with a dose of 50 mg/kg, group 2 (K2) with a dose of 75 mg/kg and group 3 (K3) with a dose of 100 mg/kg for 30 days. Each group repeated 10 rats. Statistical data analysis using SPSS for Windows version 20, and analysis of variance (variance) using Duncan at a significance level of 95%. The results obtained in this study were that the provision of tea in the form of steeping Moringa water significantly (P < 0.05) could lower cholesterol, reduce LDL and increase HDL. In conclusion, giving a dose of 75 mg/kg and a dose of 100 mg/kg can reduce cholesterol, LDL and increase HDL effectively.
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References
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Hairunnisa, M. 2008. Pengaruh Pemberian Buah Pare (Momordicacharantia) Terhadap Kadar
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histopatologi jantung tikus putih (rattus norvegicus) model hiperkolesterolemia. Phd thesis. Universitas sebelas maret.
Rajanandh, M.G., Satishkumar, M.N., Elango, K., suresh, B. 2012. Moringa Oleifera Lam. A
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pharmocology, j.s.s. Tamil Nadu – 603 203. India
Romadhoni, D.A., Murwani, S., Oktavianie, D.A., 2012. Efek Pemberian Ekstrak Air Daun
Kelor (Moringa oleifera lam.) Terhadap Kadar LDL danHDL Serum Tikus Putih
(Rattus norvegicus) Strain Wistar Yang Diberi Diet Aterogenik, Fakultas Kedokteran
Hewan Universitas Brawijaya, Malang
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Sachan, Dipti. 2011. In-Vitro & In-Vivo Efficacy Of Moringa Oleifera PlantConstituents In
Urolithiasis As Antilithiatic Drug. Institute of Pharmacy, Bundelkhand University,
Jhansi, Uttar Pradesh, India IJPSR Vol. 2, Issue 7 )
Stohs SJ and Hartman MJ. 2015. Review Of The Safety and Efficacy Of Moringa Oleifera.
Phyther Res. 29(6):796–804
Susilo, K. D., & Rachmad. (2008). Sosiologi Lingkungan. Jakarta: Rajawali Pers
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( M oringa oleifera ). Bul Pertan Perkota.5(30):35–44.)
Vongsak, B., Sithisarn, P. & Gritsanapan, W., 2013. Bioactive contents and free radical
scavenging activity of Moringa oleifera leaf extract under different storage conditions.
Industrial Crops & Products, 49, pp.419–421. Available at: http://dx.doi.org/10.1016/j.indcrop.2013.05.018.
Waji, R. A. Sugrani, A. 2009. Makalah Kimia Organik Bahan Alam Flavanoid (quercetin).
Program S2 Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas hasanuddin.
Makasar.
Zarrabal, O. C., Waliszewski, S. M., Dermitz, D. M. B., Flores, Z. O., Jones, P. M. H., Hipolito, C. N., & Infazon, R. M. (2005). The consumption of hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats. Plants Foods for Human Nutrition, 60(4), 153-159.
Zuraida R. 2015. Faktor Risiko Pola Makan dan Hubungannya dengan Penyakit Jantung pada
Pria dan Wanita Dewasa di Provinsi Lampung Dietary Risk Factors and Corelation with
Heart Disease on Men and Woman in Lampung Province.;1–5.
AOAC. 2005. Official Method of Analysis, In: Helrich, K. (Ed.). 15th Eds. Arlington:
Association of Official Analytical Chemists
Aprila Fajrin. 2010. Aktivitas Ekstrak Etanol Ketan Hitam untuk Menurunkan Kadar Kolesterol. Jurnal Farmasi Indonesia. Vol. 5 No. 2
Brand, K. 1996. Activated Transcription Factor Nuclear Factor Kappa Beta Is Present In
Atherosclerotic Lesion. Journal of ClinicalInvestigation. 97: 1715-1722.
Cherian, S., Lopaschuk, G.D. & Carvalho, E., 2012. Cellular cross-talk between epicardial
adipose tissue and myocardium in relation to the pathogenesis of cardiovascular
disease. Am J Physiol Endocrinol Metab, 303(8), pp.E937-49
Duarte, M.M.M.F. et al., 2010. Oxidative stress in hypercholesterolemia and its association
with Ala16Val superoxide dismutase gene polymorphism. Clinical Biochemistry,
43(13–14), pp.1118–1123.
Fahey, J.W., 2005. Moringa oleifera: A Review of the Medical Evidence for Its Nutritional,
Therapeutic, and Prophylactic Properties. Part 1. Tree for Life Journal, pp.1–24.
Hairunnisa, M. 2008. Pengaruh Pemberian Buah Pare (Momordicacharantia) Terhadap Kadar
HDL dan LDL Kolesterol Serum Tikus Jantan Strain Wistar yang diberi Diet Tinggi Lemak. Fakultas Kedokteran. Universitas Diponegoro. Semarang.
Hall, J.E., 2011. Guyton dan Hall : Buku Ajar Fisiologi Kedokteran, Singapura: Elsevier Ltd.
Kee J. 2017. Pedoman Pemeriksaan Laboratorium & Diagnostik. EGC.
Logu, T. 2005. Electrophoresis in Gels. Dalam Jan christer Janson & Lary Ryden (Eds). Protein
Purification: Principles, High-Resolution Methods, and Applications (2nd ed)
(Halaman 464-469). New York: John Wiley & sons, Inc., Punlication.
Marks DB, Marks AD, Smith CM. 2000. Metabolisme Kolesterol dan Lipoprotein Darah. Penerbit Buku Kedokteran EGC; 2000, Jakarta.
Mukhriani, Mukhriani, et al. 2017. Uji efektivitas ekstrak etanol daun kelor (moringa oleifera
l) terhadap penurunan kadar kolesterol darah pada mencit (mus musculus) jantan. Jurnal farmasi uin alauddin makassar, 2.3: 115-120
Muljadi, E., Adenin, I.2010. Profil Lipid pada pemakaian KB Depo Medroksi Progesteron Asetat Selama1 tahun Medan. Departemen Obstetri dan Ginekologi. Fakultas Kedokteran USU/RSUP. H. Adam Malik Medan.
Murray, R.K. et al., 2003. Biokimia Harper, Jakarta: EGC
Raden Ismail, A. 2017. Efek ekstrak daun kelor (moringa oleifera, lam.) Terhadap gambaran
histopatologi jantung tikus putih (rattus norvegicus) model hiperkolesterolemia. Phd thesis. Universitas sebelas maret.
Rajanandh, M.G., Satishkumar, M.N., Elango, K., suresh, B. 2012. Moringa Oleifera Lam. A
Herbal Medicine for Hyperlipidemia : A Pre-Clinical Report. Departemen of
pharmocology, j.s.s. Tamil Nadu – 603 203. India
Romadhoni, D.A., Murwani, S., Oktavianie, D.A., 2012. Efek Pemberian Ekstrak Air Daun
Kelor (Moringa oleifera lam.) Terhadap Kadar LDL danHDL Serum Tikus Putih
(Rattus norvegicus) Strain Wistar Yang Diberi Diet Aterogenik, Fakultas Kedokteran
Hewan Universitas Brawijaya, Malang
RISKESDAS. 2013. Laporan Nasional 2013.;1–384.)
Sachan, Dipti. 2011. In-Vitro & In-Vivo Efficacy Of Moringa Oleifera PlantConstituents In
Urolithiasis As Antilithiatic Drug. Institute of Pharmacy, Bundelkhand University,
Jhansi, Uttar Pradesh, India IJPSR Vol. 2, Issue 7 )
Stohs SJ and Hartman MJ. 2015. Review Of The Safety and Efficacy Of Moringa Oleifera.
Phyther Res. 29(6):796–804
Susilo, K. D., & Rachmad. (2008). Sosiologi Lingkungan. Jakarta: Rajawali Pers
Syarifah Aminah . 2015. Kandungan Nut risi dan Sifat Fungsional Tanam an Kelor
( M oringa oleifera ). Bul Pertan Perkota.5(30):35–44.)
Vongsak, B., Sithisarn, P. & Gritsanapan, W., 2013. Bioactive contents and free radical
scavenging activity of Moringa oleifera leaf extract under different storage conditions.
Industrial Crops & Products, 49, pp.419–421. Available at: http://dx.doi.org/10.1016/j.indcrop.2013.05.018.
Waji, R. A. Sugrani, A. 2009. Makalah Kimia Organik Bahan Alam Flavanoid (quercetin).
Program S2 Fakultas Matematika dan Ilmu Pengetahuan Alam Universitas hasanuddin.
Makasar.
Zarrabal, O. C., Waliszewski, S. M., Dermitz, D. M. B., Flores, Z. O., Jones, P. M. H., Hipolito, C. N., & Infazon, R. M. (2005). The consumption of hibiscus sabdariffa dried calyx ethanolic extract reduced lipid profile in rats. Plants Foods for Human Nutrition, 60(4), 153-159.
Zuraida R. 2015. Faktor Risiko Pola Makan dan Hubungannya dengan Penyakit Jantung pada
Pria dan Wanita Dewasa di Provinsi Lampung Dietary Risk Factors and Corelation with
Heart Disease on Men and Woman in Lampung Province.;1–5.
Published
2022-09-02
How to Cite
SUASKARA, Ida Bagus Made; ERMAYANTI, Ni Gusti Ayu Manik.
The THE EFFECTIVENESS OF MORINGA LEAF TEA ON MALE WHITE RATS TO REDUCE CHOLESTEROL LEVELS.
SIMBIOSIS, [S.l.], v. 10, n. 2, p. 164-172, sep. 2022.
ISSN 2337-7224. Available at: <https://ojs.unud.ac.id/index.php/simbiosis/article/view/82525>. Date accessed: 23 nov. 2024.
doi: https://doi.org/10.24843/JSIMBIOSIS.2022.v10.i02.p04.
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