SIDE EFFECTS PROFILE OF ANTIPLATELET MEDICATION IN PATIENTS WITH CORONARY HEART DISEASE AT BHAYANGKARA HOSPITAL BALI-INDONESIA

  • Anak Agung Indah Astrijayanti Clinical Pharmacy Department, Universitas Bali Internasional, Bali-Indonesia
  • Made Krisna Adi Jaya Department of Pharmacy, Faculty of Math and Science, Udayana University, Bali, Indonesia
  • Ida Ayu Manik Partha Sutema Clinical Pharmacy Department, Universitas Bali Internasional, Bali-Indonesia
  • Ni Putu Wulanda Evayanti Department of Pharmacy, Faculty of Math and Science, Udayana University
  • Ni Ketut Tria Purnamisari Department of Pharmacy, Faculty of Math and Science, Udayana University
DOI: https://doi.org/10.24843/JPSA.2020.v02.i02.p02

Abstract

Introduction: Coronary heart disease (CHD) is a disorder of heart function due to a lack of blood in the heart muscle due to narrowing of the coronary arteries. Antiplatelet in patients with CHD is a therapy that must be obtained by patients throughout their lives to prevent recurrent attacks and deaths from CHD. In the Province of Bali, especially in Denpasar, there is a lack of information about the type of side effects that occur on antiplatelet medication, so it is necessary to do a related study. Objective: The aim of this study is to identify the type of side effects that occur on antiplatelet medication in patients with CHD. Methods: A cross-sectional study involving 97 patients was done by observed the CHD patients treated with antiplatelet medication. Side effects were evaluate using Naranjo Algorithm. Patients were divided into three groups, including a low dose aspirin user group, clopidogrel user group, and aspirin-clopidogrel combination user group. Results: Antiplatelet side effects that occur in patients include headache (2.06%), diarrhea (1.03%), cyanosis (1.03%), gastrointestinal bleeding (8.25%), heartburn (11.34%), and nausea (6.19%). These side effects only occurred in 31.96% of the total subjects. The incidence of aspirin side effects was significantly greater than clopidogrel as well as aspirin-clopidogrel in combination (p <0.05). Conclusion: Patients with CHD who use antiplatelet agents in the long term to be more aware of the potential side effects that will occur, especially heartburn in chronic low-dose aspirin users.


Keywords: Coronary Heart Disease, Side Effects, Antiplatelet, Aspirin, Clopidogrel

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Published
2020-12-01
How to Cite
ASTRIJAYANTI, Anak Agung Indah et al. SIDE EFFECTS PROFILE OF ANTIPLATELET MEDICATION IN PATIENTS WITH CORONARY HEART DISEASE AT BHAYANGKARA HOSPITAL BALI-INDONESIA. Journal Pharmaceutical Science and Application, [S.l.], v. 2, n. 2, p. 44-48, dec. 2020. ISSN 2301-7708. Available at: <https://ojs.unud.ac.id/index.php/jpsa/article/view/61661>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.24843/JPSA.2020.v02.i02.p02.
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Vol 2 No 2 (2020): Journal Pharmaceutical Science and Application
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Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.