HUBUNGAN ANTARA HIPERURIKEMIA DENGAN MICROALBUMINURIA PADA MASYARAKAT DESA LEGIAN KUTA BALI

Abstract

Microalbuminuria has been linking to cardiovascular (CV) risk in patients with diabetes or hypertension in unselected
general population. Serum Uric Acid (UA) is an emerging novel risk factor for CV disease. The aim of our study was to evaluate
the correlations between hyperucemia and microalbuminuria in the adult Legian Kuta Village population. We selected eligible
136 participants of adult (>18 years old) in Legian Kuta village who agreed to participate. We excluded diabetes mellitus,
hypertension, urinary tract infection, and fever. We measured total cholesterol, HDL, LDL-cholesterol, triglyseride, fasting and
2-hour post prandial blood sugar, serum creatinine, serum uric acid, systolc-diastolic blood pressure and microalbuminuria
(Urinary Albumin/Creatinine Ratio, ACR).
The prevalence of hyperuricemia in our study was 16.9 % while microalbuminuria was 5.1 % (ACR 30 ! 299  g/mg
creatinine) and macroalbuminuria 1.5% (ACR > 300  g/mg creatinine). Hyperuricemia and obesity signiÞ cantly correlated with
microalbuminuria by Bivariate Analysis Spearmanrho correlation r = 0.274, p = 0.001; r = 0.178, p = 0.038 (p < 0.05) respectively.
Age, sex, smoking, total cholesterol, LDL, HDL and triglyseride were not signiÞ cantly correlated with microalbuminuria (p >
0.05). In a stepwise multiple logistic regression model, hyperuricemia to microalbuminuria remained signiÞ cantly correlated
with R Square 0.280 and prevalence ratio 7.90; p = 0.013; 95% CI 1.54 ! 40.60. Obesity was not signiÞ cantly correlated with
microalbuminuria p = 0.161; 95% CI 0.59 ! 23.03. Our study showed hyperuricemia was signiÞ cantly correlated, as independent
predictors to microalbuminuria.