PERAN SISTEM FlBRINOL1S1S PADA BERBAGAI PROSES FISIOLOGIS DAN PATOLOGIS

Abstract

Plasminogen can be converted to plasmin either by t-PA or u-PA. A dual role for these pathways is
now well established where t-PA is involved in fibrin homeostasis and u-PA is primarily involved in cell
migration and tissue remodelling. Using this mechanism thrombolytic terapy of myocardial infarction and
some other thromboembolic diseases have been introduced. Thrombolytic therapy could be improved by
earlier and accelerated treatment, the used of plasminogen activator with increased thrombolytic potency
such as reteplase, tenetecplase and staphylokinase and the use of more specific and potent anticoagulant and
antiplatelet agents. Increased activity of matrix metalloproteinases (MMPs) has been implicated in
numerous disease processes, including tumor growth and metastases, arthritis, and periodontal disease. It is
now becoming increasingly clear that extracelluler matrix degradation by M M Ps is also involved in the
pathogenesis of cardiovascular disease, including atherosclerosis, restenosis, dilated cardiomyapathi,and
myocardial infarction. Administration of synthetic MMP inhibitor in experimental animal models of; these
cardiovascular disease significantly inhibits the progression of respectivelyatherosclerotic lesion formation,
neointima formation, left ventricular remodeling, pump dysfunction, and infarc healing.