Narrative Review: Analisis Fitokimia Dan Manfaat Ekstrak Ketepeng Cina (Cassia alata L.) Sebagai Antijamur
Abstract
Indonesia is known to have various types of plants that can be used in medicine, one of which is Cassia alata. Cassia alata is a plant that has many properties so it can be used as herbal medicine or traditional medicine. One of the properties of the Cassia alata plant that has been widely studied is as an antifungal. Every part of the Cassia alata plant has secondary metabolites. Cassia alata leaves contain secondary metabolites of alkaloids, steroids, phenols, glycosides, terpenoids and flavonoids. Cassia alata flowers contain flavonoids, tannins and phenolic compounds and saponins. Cassia alata level contains alkaloids, flavonoids, glycosides, phytosterols, quinones, tannins and terpenoids. Compounds that have a role or antifungal activity in Cassia alata are phenolics, tannins, flavonoids, saponins, triterpenoids, steroids, and alkaloids.
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References
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Alioes, Y., & Kartika, A. (2019). Uji Potensi Antijamur Candida Albicans Ekstrak Daun Gelinggang (Cassia Alata L.) Dibandingkan Dengan Sediaan Daun Sirih Yang Beredar Di Pasaran Secara in Vitro. Jurnal Kimia Riset, 3(2), 108. https://doi.org/10.20473/jkr.v3i2.12040
Edo, T., Erina, & Fakhrurrazi. (2017). Uji Daya Hambat Ekstrak Etanol Daun Ketepeng Cina (Cassia alata) Terhadap Pertumbuhan Jamur Trichophyton sp. Secara In Vitro. Jimvet, 1(1), 40–45.
Essiett, U. A., & Bassey, I. E. (2013). Comparative phytochemical screening and nutritional potentials of the flowers (petals) of senna alata (l) roxb, senna hirsuta (l.) Irwin and barneby, and Senna obtusifolia (l.) Irwin and barneby (fabaceae). Journal of Applied Pharmaceutical Science, 3(8), 97–101. https://doi.org/10.7324/JAPS.2013.3817
Felhi, S., Daoud, A., Hajlaoui, H., Mnafgui, K., Gharsallah, N., & Kadri, A. (2017). Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits. Food Science and Technology (Brazil), 37(3), 483–492. https://doi.org/10.1590/1678-457x.23516
G, Ehiowemwenguan, J.E, I., & J. M, Y. (2014). Antimicrobial Qualities of Senna Alata. IOSR Journal of Pharmacy and Biological Sciences, 9(2), 47–52. https://doi.org/10.9790/3008-09244752
Guerra, F., Ansari, A. A., Kurup, R., & Subramanian, G. (2020). Antifungal Activity of Senna alata, Senna bicapsularis and Pityrogramma calomelanos. Journal of Complementary and Alternative Medical Research, September, 11–21. https://doi.org/10.9734/jocamr/2020/v10i330164
Hamzah, H., Hertiani, T., Pratiwi, S. U. T., Nuryastuti, T., & Gani, A. P. (2020). Antibiofilm studies of zerumbone against polymicrobial biofilms of staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, and candida albicans. International Journal of Pharmaceutical Research, 12(September), 1307–1314. https://doi.org/10.31838/ijpr/2020.SP1.211
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James, O. O., Emmanuel, O. O., Saanumi, G. A., Akinkunmi, O. O., & Adekanmi, A. A. (2022). Senna Alata Leaf and Stem: Phytochemical Screening, Nutritional Content, and Antimicrobial Activities. Journal of Environmental Impact and Management Policy, 26, 1–11. https://doi.org/10.55529/jeimp.26.1.11
Khatri, D., & Lawati, A. M. (2022). Qualitative and Quantitative Analysis of Phytochemical Constituents of Alternanthera brasiliana (L.) Kuntze and Cassia alata (L.) using Different Organic Solvents. Himalayan Journal of Science and Technology, 6(1), 29–37. https://doi.org/10.3126/hijost.v6i1.50650
Lantah, P. L., Montolalu, L. A. D. Y., & Reo, A. R. (2017). Kandungan Fitokimia dan Aktivitas Antioksidan Ekstrak Metanol Rumput Laut Kappaphycus alvarezii. Jurnal Media Teknologi Hasil Perikanan, 5(3), 167–173.
Lathifah, Q. A., Turista, D. D. R., & Puspitasari, E. (2021). Daya Antibakteri Ketepeng Cina (Cassia alata L.) Terhadap Staphylococcus aureus, Pseudomonas aerugenosa, dan Klebsiella pneumonia. Jurnal Analis Kesehatan, 10(1), 29. https://doi.org/10.26630/jak.v10i1.2718
Le, P. T. Q. (2019). Phytochemical screening and antimicrobial activity of extracts of Cassia alata L. Leaves and seeds. Bulgarian Chemical Communications, 51(3), 378–383. https://doi.org/10.34049/bcc.51.3.5049
Mathlail, F., Marfu’ah, N., & Lija Oktya, A. (2018). Aktivitas Antifungi Daun Ketepeng Cina (Cassia Alata L.) Fraksi Etanol, N-Heksan, Dan Kloroform Terhadap Jamur Microsporium canis. Pharmaceutical Journal of Islamic Pharmacy, 2(1), 28. https://doi.org/10.21111/pharmasipha.v2i1.2134
Nur Ahsani, D. (2014). Respon Imun Pada Infeksi Jamur. Jurnal kedokteran dan kesehatan Indonesia, 6(2), 55–65. https://doi.org/10.20885/jkki.vol6.iss2.art2
Octaria, Z., & Saputra, R. (2015). Pengaruh jenis pelarut terhadap jumlah ekstrak dan daya antifungi daun ketepeng cina (. Jurnal Photon, 5(2), 15–21.
Oktavia, S., Pebryantika, S., & Dharma, S. (2015). Pengaruh Pemberian Ekstrak Etanol Daun Ketepeng Cina (Cassia alata L.) Terhadap Waktu Pendarahan, Pembekuan Darah dan Jumlah Trombosit Mencit Putih Jantan. Jurnal Farmasi Higea, 7(1), 1–9.
Okwu, D. E., & Nnamdi, F. U. (2011). Cannabinoid Dronabinol alkaloid with antimicrobial activity from Cassia alata Linn. Der Chemica Sinica, 2(2), 247–254.
Rahaman, M., Hasan, A. M., Ali, M., & Ali, M. (2006). A Flavone from the Leaves of Cassia Alata. Bangladesh Journal of Scientific and Industrial Research, 41(1), 93–96. https://doi.org/10.3329/bjsir.v41i1.276
Rahman, F. Bin, Ahmed, S., Noor, P., Rahman, M. M. M., Huq, S. M. A., Akib, M. T. E., & Shohael, A. M. (2020). A comprehensive multi-directional exploration of phytochemicals and bioactivities of flower extracts from Delonix regia (Bojer ex Hook.) Raf., Cassia fistula L. and Lagerstroemia speciosa L. Biochemistry and Biophysics Reports, 24(August), 100805. https://doi.org/10.1016/j.bbrep.2020.100805
Rahmawati, R., Muflihunna, A., & Kusuma, A. T. (2015). Analisis Kadar Flavonoid Dan Fenolik Total Fraksi Etil Asetat Daun Ketepeng Cina (Senna alata (L.) Roxb) dengan Metode Spektrofotometri UV-Visible. Jurnal Ilmiah As-Syifaa, 7(1), 10–18. https://doi.org/10.33096/jifa.v7i1.16
Raji, P., J, S., Sugithara, M., Renugadevi, K., & Samrot, A. V. (2016). Phytochemical Screening and Bioactivity Study of cassia alata Leaves P. Biosciences Biotechnology Research Asia, 13(1), 339–346. https://doi.org/10.13005/bbra/2038
Safitri, E. R., Rohama, & Vidiasari, P. (2020). Skrining Fitokimia Serta Uji Aktivitas Antioksidan Ekstrak Bunga Ketepeng Cina (Senna alata (l.) Roxb.) Dengan Metode DPPH. Journal of Pharmaceutical Care and Science, 1(1), 10–18.
Saito, S., Silva, G., Santos, R. X., Gosmann, G., Pungartnik, C., & Brendel, M. (2012). Astragalin from cassia alata induces DNA adducts in vitro and repairable DNA damage in the yeast saccharomyces cerevisiae. International Journal of Molecular Sciences, 13(3), 2846–2862. https://doi.org/10.3390/ijms13032846
Shailla Gharnita, Y., Lelyana, S., & Sugiaman, V. K. (2019). Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM) Ekstrak Etanol Daun Ketepeng Cina (Cassia alata L.) Terhadap Pertumbuhan Candida albicans. SONDE (Sound of Dentistry), 4(1), 1–15. https://doi.org/10.28932/sod.v4i1.1766
Sharma, P., Pandey, D., Rizvi, A. F., & Gupta, A. K. (2015). Antimicrobial activity of Cassia alata from Raipur region against clinical and MTCC isolates Original Research Article Antimicrobial activity of Cassia alata from Raipur region against clinical and MTCC isolates Nature has been a source of wide diversity. International Journal of Current Microbiology and Applied Sciences, 4(1), 330–339.
Sulistyo, M. H., Pani, S., & Kumaji, S. (2018). Pengaruh Ekstrak Daun Ketepeng CIna (Cassia alata L.) Terhadap Pertumbuhan Jamur Malassezia furfur Penyebab Ketombe. 14, 63–65. https://doi.org/10.15900/j.cnki.zylf1995.2018.02.001
Toh, S. C., Lihan, S., Bunya, S. R., & Leong, S. S. (2023). In vitro antimicrobial efficacy of Cassia alata (Linn.) leaves, stem, and root extracts against cellulitis causative agent Staphylococcus aureus. BMC complementary medicine and therapies, 23(1), 85. https://doi.org/10.1186/s12906-023-03914-z
Triana, O., Prasetya, F., Kuncoro, H., & Rijai, L. (2016). Aktivitas Antijamur Ekstrak Daun Ketepeng Cina (Cassia alata L.). Jurnal Sains dan Kesehatan, 1(6), 311–315. https://doi.org/10.25026/jsk.v1i6.67
Umaru, I. J., Ejeh, Y. O., Ahmed, M. U., Ezekiel, I., & Isaac, K. (2022). GC-MS , Radicals Scavenging Capacity and Antidiabetic Effect of Senna alata Seed Extract in Type II-Induced Diabetes Mellitus in Rats. 7924, 49–58.
Wuthi-Udomlert, M., Kupittayanant, P., & Gritsanapan, W. (2010). in Vitro Evaluation of Antifungal Activity of Anthraquinone Derivatives of Senna Alata. J Health Res, 24(3), 117–122.
Adi Saputra, Tafdhila, & Mayaranti Wilsya. (2021). Aktivitas Antijamur Ekstrak Etanol Bunga Ketepeng Cina (Senna alata l) Terhadap Jamur Candida albicans. Jurnal Kesehatan : Jurnal Ilmiah Multi Sciences, 11(2), 79–85. https://doi.org/10.52395/jkjims.v11i2.326
Akhmadi, C., Utami, W., & Annisaa, E. (2022). Narrative Review : Senyawa Fitokimia Dan Aktivitas. LP2M UST Jogja, 390–400.
Alioes, Y., & Kartika, A. (2019). Uji Potensi Antijamur Candida Albicans Ekstrak Daun Gelinggang (Cassia Alata L.) Dibandingkan Dengan Sediaan Daun Sirih Yang Beredar Di Pasaran Secara in Vitro. Jurnal Kimia Riset, 3(2), 108. https://doi.org/10.20473/jkr.v3i2.12040
Edo, T., Erina, & Fakhrurrazi. (2017). Uji Daya Hambat Ekstrak Etanol Daun Ketepeng Cina (Cassia alata) Terhadap Pertumbuhan Jamur Trichophyton sp. Secara In Vitro. Jimvet, 1(1), 40–45.
Essiett, U. A., & Bassey, I. E. (2013). Comparative phytochemical screening and nutritional potentials of the flowers (petals) of senna alata (l) roxb, senna hirsuta (l.) Irwin and barneby, and Senna obtusifolia (l.) Irwin and barneby (fabaceae). Journal of Applied Pharmaceutical Science, 3(8), 97–101. https://doi.org/10.7324/JAPS.2013.3817
Felhi, S., Daoud, A., Hajlaoui, H., Mnafgui, K., Gharsallah, N., & Kadri, A. (2017). Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits. Food Science and Technology (Brazil), 37(3), 483–492. https://doi.org/10.1590/1678-457x.23516
G, Ehiowemwenguan, J.E, I., & J. M, Y. (2014). Antimicrobial Qualities of Senna Alata. IOSR Journal of Pharmacy and Biological Sciences, 9(2), 47–52. https://doi.org/10.9790/3008-09244752
Guerra, F., Ansari, A. A., Kurup, R., & Subramanian, G. (2020). Antifungal Activity of Senna alata, Senna bicapsularis and Pityrogramma calomelanos. Journal of Complementary and Alternative Medical Research, September, 11–21. https://doi.org/10.9734/jocamr/2020/v10i330164
Hamzah, H., Hertiani, T., Pratiwi, S. U. T., Nuryastuti, T., & Gani, A. P. (2020). Antibiofilm studies of zerumbone against polymicrobial biofilms of staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, and candida albicans. International Journal of Pharmaceutical Research, 12(September), 1307–1314. https://doi.org/10.31838/ijpr/2020.SP1.211
Hasanah, S. N., & Widowati, L. (2016). Jamu Pada Pasien Tumor/Kanker sebagai Terapi Komplementer. Jurnal Kefarmasian Indonesia, 6(1), 49–59. https://doi.org/10.22435/jki.v6i1.5469.49-59
James, O. O., Emmanuel, O. O., Saanumi, G. A., Akinkunmi, O. O., & Adekanmi, A. A. (2022). Senna Alata Leaf and Stem: Phytochemical Screening, Nutritional Content, and Antimicrobial Activities. Journal of Environmental Impact and Management Policy, 26, 1–11. https://doi.org/10.55529/jeimp.26.1.11
Khatri, D., & Lawati, A. M. (2022). Qualitative and Quantitative Analysis of Phytochemical Constituents of Alternanthera brasiliana (L.) Kuntze and Cassia alata (L.) using Different Organic Solvents. Himalayan Journal of Science and Technology, 6(1), 29–37. https://doi.org/10.3126/hijost.v6i1.50650
Lantah, P. L., Montolalu, L. A. D. Y., & Reo, A. R. (2017). Kandungan Fitokimia dan Aktivitas Antioksidan Ekstrak Metanol Rumput Laut Kappaphycus alvarezii. Jurnal Media Teknologi Hasil Perikanan, 5(3), 167–173.
Lathifah, Q. A., Turista, D. D. R., & Puspitasari, E. (2021). Daya Antibakteri Ketepeng Cina (Cassia alata L.) Terhadap Staphylococcus aureus, Pseudomonas aerugenosa, dan Klebsiella pneumonia. Jurnal Analis Kesehatan, 10(1), 29. https://doi.org/10.26630/jak.v10i1.2718
Le, P. T. Q. (2019). Phytochemical screening and antimicrobial activity of extracts of Cassia alata L. Leaves and seeds. Bulgarian Chemical Communications, 51(3), 378–383. https://doi.org/10.34049/bcc.51.3.5049
Mathlail, F., Marfu’ah, N., & Lija Oktya, A. (2018). Aktivitas Antifungi Daun Ketepeng Cina (Cassia Alata L.) Fraksi Etanol, N-Heksan, Dan Kloroform Terhadap Jamur Microsporium canis. Pharmaceutical Journal of Islamic Pharmacy, 2(1), 28. https://doi.org/10.21111/pharmasipha.v2i1.2134
Nur Ahsani, D. (2014). Respon Imun Pada Infeksi Jamur. Jurnal kedokteran dan kesehatan Indonesia, 6(2), 55–65. https://doi.org/10.20885/jkki.vol6.iss2.art2
Octaria, Z., & Saputra, R. (2015). Pengaruh jenis pelarut terhadap jumlah ekstrak dan daya antifungi daun ketepeng cina (. Jurnal Photon, 5(2), 15–21.
Oktavia, S., Pebryantika, S., & Dharma, S. (2015). Pengaruh Pemberian Ekstrak Etanol Daun Ketepeng Cina (Cassia alata L.) Terhadap Waktu Pendarahan, Pembekuan Darah dan Jumlah Trombosit Mencit Putih Jantan. Jurnal Farmasi Higea, 7(1), 1–9.
Okwu, D. E., & Nnamdi, F. U. (2011). Cannabinoid Dronabinol alkaloid with antimicrobial activity from Cassia alata Linn. Der Chemica Sinica, 2(2), 247–254.
Rahaman, M., Hasan, A. M., Ali, M., & Ali, M. (2006). A Flavone from the Leaves of Cassia Alata. Bangladesh Journal of Scientific and Industrial Research, 41(1), 93–96. https://doi.org/10.3329/bjsir.v41i1.276
Rahman, F. Bin, Ahmed, S., Noor, P., Rahman, M. M. M., Huq, S. M. A., Akib, M. T. E., & Shohael, A. M. (2020). A comprehensive multi-directional exploration of phytochemicals and bioactivities of flower extracts from Delonix regia (Bojer ex Hook.) Raf., Cassia fistula L. and Lagerstroemia speciosa L. Biochemistry and Biophysics Reports, 24(August), 100805. https://doi.org/10.1016/j.bbrep.2020.100805
Rahmawati, R., Muflihunna, A., & Kusuma, A. T. (2015). Analisis Kadar Flavonoid Dan Fenolik Total Fraksi Etil Asetat Daun Ketepeng Cina (Senna alata (L.) Roxb) dengan Metode Spektrofotometri UV-Visible. Jurnal Ilmiah As-Syifaa, 7(1), 10–18. https://doi.org/10.33096/jifa.v7i1.16
Raji, P., J, S., Sugithara, M., Renugadevi, K., & Samrot, A. V. (2016). Phytochemical Screening and Bioactivity Study of cassia alata Leaves P. Biosciences Biotechnology Research Asia, 13(1), 339–346. https://doi.org/10.13005/bbra/2038
Safitri, E. R., Rohama, & Vidiasari, P. (2020). Skrining Fitokimia Serta Uji Aktivitas Antioksidan Ekstrak Bunga Ketepeng Cina (Senna alata (l.) Roxb.) Dengan Metode DPPH. Journal of Pharmaceutical Care and Science, 1(1), 10–18.
Saito, S., Silva, G., Santos, R. X., Gosmann, G., Pungartnik, C., & Brendel, M. (2012). Astragalin from cassia alata induces DNA adducts in vitro and repairable DNA damage in the yeast saccharomyces cerevisiae. International Journal of Molecular Sciences, 13(3), 2846–2862. https://doi.org/10.3390/ijms13032846
Shailla Gharnita, Y., Lelyana, S., & Sugiaman, V. K. (2019). Kadar Hambat Minimum (KHM) dan Kadar Bunuh Minimum (KBM) Ekstrak Etanol Daun Ketepeng Cina (Cassia alata L.) Terhadap Pertumbuhan Candida albicans. SONDE (Sound of Dentistry), 4(1), 1–15. https://doi.org/10.28932/sod.v4i1.1766
Sharma, P., Pandey, D., Rizvi, A. F., & Gupta, A. K. (2015). Antimicrobial activity of Cassia alata from Raipur region against clinical and MTCC isolates Original Research Article Antimicrobial activity of Cassia alata from Raipur region against clinical and MTCC isolates Nature has been a source of wide diversity. International Journal of Current Microbiology and Applied Sciences, 4(1), 330–339.
Sulistyo, M. H., Pani, S., & Kumaji, S. (2018). Pengaruh Ekstrak Daun Ketepeng CIna (Cassia alata L.) Terhadap Pertumbuhan Jamur Malassezia furfur Penyebab Ketombe. 14, 63–65. https://doi.org/10.15900/j.cnki.zylf1995.2018.02.001
Toh, S. C., Lihan, S., Bunya, S. R., & Leong, S. S. (2023). In vitro antimicrobial efficacy of Cassia alata (Linn.) leaves, stem, and root extracts against cellulitis causative agent Staphylococcus aureus. BMC complementary medicine and therapies, 23(1), 85. https://doi.org/10.1186/s12906-023-03914-z
Triana, O., Prasetya, F., Kuncoro, H., & Rijai, L. (2016). Aktivitas Antijamur Ekstrak Daun Ketepeng Cina (Cassia alata L.). Jurnal Sains dan Kesehatan, 1(6), 311–315. https://doi.org/10.25026/jsk.v1i6.67
Umaru, I. J., Ejeh, Y. O., Ahmed, M. U., Ezekiel, I., & Isaac, K. (2022). GC-MS , Radicals Scavenging Capacity and Antidiabetic Effect of Senna alata Seed Extract in Type II-Induced Diabetes Mellitus in Rats. 7924, 49–58.
Wuthi-Udomlert, M., Kupittayanant, P., & Gritsanapan, W. (2010). in Vitro Evaluation of Antifungal Activity of Anthraquinone Derivatives of Senna Alata. J Health Res, 24(3), 117–122.
Published
2023-08-28
How to Cite
UDIN, Baha et al.
Narrative Review: Analisis Fitokimia Dan Manfaat Ekstrak Ketepeng Cina (Cassia alata L.) Sebagai Antijamur.
Jurnal Farmasi Udayana, [S.l.], p. 46-51, aug. 2023.
ISSN 2622-4607.
Available at: <https://ojs.unud.ac.id/index.php/jfu/article/view/99991>. Date accessed: 13 may 2024.
doi: https://doi.org/10.24843/JFU.2023.v12.i01.p08.
Section
Articles
