Comparative Methods of Increasing Drug Dissolution Rate
Abstract
The speed of dissolution becomes an important part in the manufacture of drugs, because it is related to drug absorption and bioavailability. In order to achieve a good dissolution rate, various methods with certain criteria are needed. This review article aims to find out various methods that can be used to increase the speed of drug dissolution, and can be used as a reference for choosing the most appropriate dissolution method. The article review method used is a narrative review type in the form of a description or explanation of methods for increasing dissolution as a comparison in terms of method selection. Journals were obtained through chrome, google scholar and researchgate using 16 journals. The results obtained are that there are several methods that can increase dissolution including amorphous co, the use of surfactants and so on. The conclusion obtained from this review of the article is that there are various methods of increasing dissolution such as the use of surfactants, co-crystals, amorphous cos and so on.
Keywords: dissolution; method; narrative review
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References
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Alkautsar, M., Deanissa, R., Zahira, L., & Sari, A. K. (2022) ‘Peningkatan Laju Disolusi Bahan Aktif Farmasi dalam Sistem Dispersi Padat’, Clinical, Pharmaceutical, Analitical and Pharmacy Community Journal, 1(1), pp. 1–7.
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Anggraeni, W. and Purnamasari, N. (2017) ‘Pembentukan Liquisolid Compact Klopidogrel Bisulfat’, Prosiding Seminar Nasional Ilmu Pengetahuan dan Teknologi Jenderal Achmad Yani (SNIJA), 1(1), pp. 11–14.
Bambang, W., Sukarto, A. and Taufiqu, N. (2007) ‘Efek Cryomilling Terhadap Struktur Mikro Sistem Bi-Mn’, Jurnal Sains Materi Indonesia, 8(3), pp. 250–254.
Citrariana, S., Lukitaningsih, E. and Nugroho, A. K. (2020) ‘Studi Perbandingan Disolusi In-Vitro Pada Formula Tablet Levofloksasin Immediate-Release Menggunakan Variasi Kadar Disintegran Sodium Starch Glycolate’, Majalah Farmaseutik, 16(1), pp. 83–90. doi: 10.22146/farmaseutik.v16i1.48941.
Darusman, F., Nabila Tazkiyatunnisa, S. and Aryani, R. (2021) ‘Pengaruh Pembentukan Kompleks Inklusi Ibuprofen-beta-Siklodekstrin dengan Metode Kopresipitasi Terhadap Kelarutan dan Laju Disolusi’, Jurnal Ilmiah Farmasi Farmasyifa, 4(2), pp. 12–21.
Dewi, A. K. and Satibi, L. (2015) ‘Kajian Pengaruh Temperatur Pengeringan Semprot (Spray Dryer) Terhadap Waktu Pengeringan Dan Rendemen Bubuk Santan Kelapa (Coconut Milk Powder)’, Konversi, 4(1), pp. 25–31.
Ermawati, D. E. and Prilantari, H. U. (2019) ‘Pengaruh Kombinasi Polimer Hidroksipropilmetilselulosa dan Natrium Karboksimetilselulosa terhadap Sifat Fisik Sediaan Matrix-based Patch Ibuprofen’, Journal of Pharmaceutical Science and Clinical Research, 2(1), pp. 109–119. doi: 10.20961/jpscr.v4i2.34525.
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Gozali, D., Bahti, H. H., Soewandhi, S. N., & Abdassah, M. (2014) ‘Pembentukan Kokristal Antara Kalsium Atorvastatin dengan Isonikotinamid dan Karakterisasinya’, Jurnal Sains Materi Indonesia, 15(2), pp. 103–110.
Haeria, Syamsi Dhuha, N. and Rahmi Azhariyani, A. (2020) ‘Potensi Pati Umbi Tire (Amorphopallus onchopyllus) Pregelatinasi Paut Silang Sebagai Bahan Tambahan Tablet Kempa Langsung’, Jurnal Ilmiah Farmasi Farmasyifa, 1(1), pp. 53–61.
Halim, A., Hamdeni, S. and Zaini, E. (2013) ‘Peningkatan Laju Disolusi Trimetoprim dengan Teknik Co- Grinding Menggunakan Polimer Polivinilpirolidon K-30’, Jurnal Ilmu Kefarmasian Indonesia, 11(1), pp. 1–6.
Handayani, R. and Abdasah, M. (2016) ‘Review : Disintegran dapat Meningkatkan Kinerja Tablet Orodispersibel (ODT) Sebagai New Drug Delivery System (NDDS)’, Jurnal Farmaka, 14(3), pp. 95–108.
Hilaliyati, N., Ben, E. S. and Zaini, E. (2017) ‘Peningkatan Laju Disolusi Ketoprofen dengan Teknik Co-Grinding Menggunakan Polimer Hidroksipropil Metilselulosa E6’, Jurnal Sains Farmasi dan Klinis, 3(2), pp. 193–201.
Islami, A., Sopyan, I., Gozali, D., & Hairunnisa. (2020) ‘Solubility Modificaion Of Piroxicam : A Review’, Ilmiah Farmako Bahari, 11(1), pp. 89–102.
Jensen, K. T., Löbmann, K., Rades, T., & Grohganz, H. (2014) ‘Improving Co-Amorphous Drug Formulations By The Addition Of The Highly Water Soluble Amino Acid, Proline’, Pharmaceutics, 6(3), pp. 416–435. doi: 10.3390/pharmaceutics6030416.
Mishra, J., Rades, T., Lobmann, K., & Grohganz, H. (2018) ‘Influence Of Solvent Composition On The Performance Of Spray-Dried Co-Amorphous Formulations’, Pharmaceutics, 10(1), pp. 1–13. doi: 10.3390/pharmaceutics10020047.
Moinuddin, S. M., Ruan, S., Huang, Y., Gao, Q., Shi, Q., Cai, B., & Cai, T. (2017) ‘Facile Formation Of Co-Amorphous Atenolol And Hydrochlorothiazide Mixtures Via Cryogenic-Milling: Enhanced Physical Stability, Dissolution And Pharmacokinetic Profile’, International Journal of Pharmaceutics, 532(1), pp. 393–400. doi: 10.1016/j.ijpharm.2017.09.020.
Noviza, D., Febriyanti, N. and Umar, S. (2015) ‘Solubilsasi Parasetamol dengan Ryoto® Sugar Ester dan Propilenglikol’, Jurnal Sains Farmasi & Klinis, 1(2), pp. 132–139. doi: 10.29208/jsfk.2015.1.2.23.
Ojarinta, R., Lerminiaux, L. and Laitinen, R. (2017) ‘Spray Drying Of Poorly Soluble Drugs From Aqueous Arginine Solution’, International Journal of Pharmaceutics, 532(1), pp. 289–298. doi: 10.1016/j.ijpharm.2017.09.015.
Rachmaniar, R., Rusdiana, T., Panatarani, C., & Joni, I. (2017) ‘Usaha Peningkatan Kelarutan dan Laju Disolusi Zar Aktif Farmasi Sukar Larut Air’, Indonesian Journal of Pharmaceutical Science and Technology, 6(2), pp. 2–6.
Rachmat, S. S. and Shovitri, M. (2021) ‘Studi Literatur Tentng Teknik Liofilisasi Untuk Preservasi Bakteri’, Jurnal Teknik ITS, 10(2), pp. 17–22.
Sagala, R. J. (2019) ‘Review: Metode Peningkatan Kecepatan Disolusi Dikombinasi Dengan Penambahan Surfaktan’, Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 5(1), pp. 84–92. doi: 10.22487/j24428744.2019.v5.i1.12360.
Santosa, D. M. and Pertiwi, F. D. (2020) ‘Formulasi dan Uji Disolusi Terbanding Tablet Lepas Lambat Natrium Diklofenak Menggunakan Methocel K100M Sebagai Matriks’, Indonesia Natural Research Pharmaceutical Journal, 5(2), pp. 1–11.
Setyawan, D., Wardhana, N. K. and Sari, R. (2015) ‘Solubility, Dissolution Test And Antimalarial Activity Of Artesunate Nicotinamide Co-Crystal Prepared By Solvent Evaporation And Slurry Methods’, Asian Journal of Pharmaceutical and Clinical Research, 8(2), pp. 164–166.
Sharma, A. and Jain, C. P. (2010) ‘Preparation And Characterization Of Solid Dispersions Of Carvedilol with PVP K30’, Research in Pharmaceutical Sciences, 5(1), pp. 49–56. Available at: http://scholarsresearchlibrary.com/ABR-vol1-iss2/ABR-2010-1-2-87-90.pdf.
Shinde, A., Jadhav, N., Shinde, O., & Patil, P. (2019) ‘Enhancement Solubility And Dissolution Rate Of Paracetamol And Ibuprofen By Coamorphous Particles Using Microwave Technique’, Asian Journal of Pharmaceutical and Clinical Research, 12(11), pp. 155–162. doi: 10.22159/ajpcr.2019.v12i11.34589.
Siswanto, A., Fudholi, A., Nugroho, A. K., & Martono, S. (2014) ‘Pengaruh Medium Dissolusi dan Penggunaan Sinker Terhadap Profil Disolusi Tablet Floating Aspirin’, Pharmacy, 11(02), pp. 1–10.
Sitompul, E. D. and Dharma, S. (2018) ‘Pengaruh Variasi Konsentrasi Media Pendingin (Quenchant) Pada Proses Quench Terhadap Kekerasan, Struktur Mikro Dan Retak Akibat Quench (Quench Crack) Dari Baja AISI 1040’, Jurnal ROTOR, 11(1), pp. 1–7.
Skotnicki, M., Jadach, B., Skotnicka, A., Milanowski, B., Tajber, L., Pyda, M., & Kujawski, J. (2021) ‘Physicochemical Characterization Of a Co-Amorphous Atorvastatin-Irbesartan System With a Potential Application In Fixed-Dose Combination Therapy’, Pharmaceutics, 13(1), pp. 1–20. doi: 10.3390/pharmaceutics13010118.
Sutiswa, S. I., Cahyati, Y. and Mudhakir, D. (2019) ‘Peningkatan Disolusi Rosuvastatin Calsium dari Sediaan Tablet dengan Teknik Liquisolid dan Pembentukan Kompleks Inklusi’, Jurnal Riset Kefarmasian Indonesia, 1(2), pp. 93–102. doi: 10.33759/jrki.v1i2.21.
Wardana, D., Ramadhan, A., Fitri Amne, D. P., & Eddiyanto. (2019) ‘Utilization of Glycerol from Used Oil as an Ester Glycerol Surfactant’, Indonesian Journal of Chemical Science and Technology (IJCST), 2(2), pp. 111–120. doi: 10.24114/ijcst.v2i2.13999.
Alatas, F., Soewandhi, S. N., Sasongko, L., & Ismunandar. (2014) ‘Kelarutan dan Stabilitas Kimia Kompleks Didanosin dengan Nikotinamid atau L-Arginin’, Jurnal Sains Materi Indonesia, 15(2), pp. 94–102.
Alfina, S., Najihudin, A. and Auliasari, N. (2022) ‘Review Pengaruh Koformer Arginin Dalam Pembuatan Ko-Amorf Dengan Metode Ball Milling’, Jurnal Ilmiah Farmako Bahari, 13(2), pp. 202–208.
Alkautsar, M., Deanissa, R., Zahira, L., & Sari, A. K. (2022) ‘Peningkatan Laju Disolusi Bahan Aktif Farmasi dalam Sistem Dispersi Padat’, Clinical, Pharmaceutical, Analitical and Pharmacy Community Journal, 1(1), pp. 1–7.
An, J. H., Lim, C., Kiyonga, A. N., Chung, I. H., Lee, I. K., Mo, K., Park, M., Youn, W., Choi, W. R., Suh, Y. G., & Jung, K. (2018) ‘Co-Amorphous Screening For The Solubility Enhancement Of Poorly Water-Soluble Mirabegron And Investigation Of Their Intermolecular Interactions And Dissolution Behaviors’, Pharmaceutics, 10(3), pp. 1–14. doi: 10.3390/pharmaceutics10030149.
Anggraeni, W. and Purnamasari, N. (2017) ‘Pembentukan Liquisolid Compact Klopidogrel Bisulfat’, Prosiding Seminar Nasional Ilmu Pengetahuan dan Teknologi Jenderal Achmad Yani (SNIJA), 1(1), pp. 11–14.
Bambang, W., Sukarto, A. and Taufiqu, N. (2007) ‘Efek Cryomilling Terhadap Struktur Mikro Sistem Bi-Mn’, Jurnal Sains Materi Indonesia, 8(3), pp. 250–254.
Citrariana, S., Lukitaningsih, E. and Nugroho, A. K. (2020) ‘Studi Perbandingan Disolusi In-Vitro Pada Formula Tablet Levofloksasin Immediate-Release Menggunakan Variasi Kadar Disintegran Sodium Starch Glycolate’, Majalah Farmaseutik, 16(1), pp. 83–90. doi: 10.22146/farmaseutik.v16i1.48941.
Darusman, F., Nabila Tazkiyatunnisa, S. and Aryani, R. (2021) ‘Pengaruh Pembentukan Kompleks Inklusi Ibuprofen-beta-Siklodekstrin dengan Metode Kopresipitasi Terhadap Kelarutan dan Laju Disolusi’, Jurnal Ilmiah Farmasi Farmasyifa, 4(2), pp. 12–21.
Dewi, A. K. and Satibi, L. (2015) ‘Kajian Pengaruh Temperatur Pengeringan Semprot (Spray Dryer) Terhadap Waktu Pengeringan Dan Rendemen Bubuk Santan Kelapa (Coconut Milk Powder)’, Konversi, 4(1), pp. 25–31.
Ermawati, D. E. and Prilantari, H. U. (2019) ‘Pengaruh Kombinasi Polimer Hidroksipropilmetilselulosa dan Natrium Karboksimetilselulosa terhadap Sifat Fisik Sediaan Matrix-based Patch Ibuprofen’, Journal of Pharmaceutical Science and Clinical Research, 2(1), pp. 109–119. doi: 10.20961/jpscr.v4i2.34525.
Ferdiansyah, R., Ardiansyah, S. A., Rachmaniar, R., & Yuniar, I. (2021) ‘The Effect of Cocrystal Formation Using Carboxylic Acid Coformer With Solvent Evaporation and Solvent Drop Grinding Methods on Bioavailability of Active Substances’, Jurnal Ilmiah Farmako Bahari, 12(1), pp. 28–38. Available at: www.journal.uniga.ac.id.
Gozali, D., Bahti, H. H., Soewandhi, S. N., & Abdassah, M. (2014) ‘Pembentukan Kokristal Antara Kalsium Atorvastatin dengan Isonikotinamid dan Karakterisasinya’, Jurnal Sains Materi Indonesia, 15(2), pp. 103–110.
Haeria, Syamsi Dhuha, N. and Rahmi Azhariyani, A. (2020) ‘Potensi Pati Umbi Tire (Amorphopallus onchopyllus) Pregelatinasi Paut Silang Sebagai Bahan Tambahan Tablet Kempa Langsung’, Jurnal Ilmiah Farmasi Farmasyifa, 1(1), pp. 53–61.
Halim, A., Hamdeni, S. and Zaini, E. (2013) ‘Peningkatan Laju Disolusi Trimetoprim dengan Teknik Co- Grinding Menggunakan Polimer Polivinilpirolidon K-30’, Jurnal Ilmu Kefarmasian Indonesia, 11(1), pp. 1–6.
Handayani, R. and Abdasah, M. (2016) ‘Review : Disintegran dapat Meningkatkan Kinerja Tablet Orodispersibel (ODT) Sebagai New Drug Delivery System (NDDS)’, Jurnal Farmaka, 14(3), pp. 95–108.
Hilaliyati, N., Ben, E. S. and Zaini, E. (2017) ‘Peningkatan Laju Disolusi Ketoprofen dengan Teknik Co-Grinding Menggunakan Polimer Hidroksipropil Metilselulosa E6’, Jurnal Sains Farmasi dan Klinis, 3(2), pp. 193–201.
Islami, A., Sopyan, I., Gozali, D., & Hairunnisa. (2020) ‘Solubility Modificaion Of Piroxicam : A Review’, Ilmiah Farmako Bahari, 11(1), pp. 89–102.
Jensen, K. T., Löbmann, K., Rades, T., & Grohganz, H. (2014) ‘Improving Co-Amorphous Drug Formulations By The Addition Of The Highly Water Soluble Amino Acid, Proline’, Pharmaceutics, 6(3), pp. 416–435. doi: 10.3390/pharmaceutics6030416.
Mishra, J., Rades, T., Lobmann, K., & Grohganz, H. (2018) ‘Influence Of Solvent Composition On The Performance Of Spray-Dried Co-Amorphous Formulations’, Pharmaceutics, 10(1), pp. 1–13. doi: 10.3390/pharmaceutics10020047.
Moinuddin, S. M., Ruan, S., Huang, Y., Gao, Q., Shi, Q., Cai, B., & Cai, T. (2017) ‘Facile Formation Of Co-Amorphous Atenolol And Hydrochlorothiazide Mixtures Via Cryogenic-Milling: Enhanced Physical Stability, Dissolution And Pharmacokinetic Profile’, International Journal of Pharmaceutics, 532(1), pp. 393–400. doi: 10.1016/j.ijpharm.2017.09.020.
Noviza, D., Febriyanti, N. and Umar, S. (2015) ‘Solubilsasi Parasetamol dengan Ryoto® Sugar Ester dan Propilenglikol’, Jurnal Sains Farmasi & Klinis, 1(2), pp. 132–139. doi: 10.29208/jsfk.2015.1.2.23.
Ojarinta, R., Lerminiaux, L. and Laitinen, R. (2017) ‘Spray Drying Of Poorly Soluble Drugs From Aqueous Arginine Solution’, International Journal of Pharmaceutics, 532(1), pp. 289–298. doi: 10.1016/j.ijpharm.2017.09.015.
Rachmaniar, R., Rusdiana, T., Panatarani, C., & Joni, I. (2017) ‘Usaha Peningkatan Kelarutan dan Laju Disolusi Zar Aktif Farmasi Sukar Larut Air’, Indonesian Journal of Pharmaceutical Science and Technology, 6(2), pp. 2–6.
Rachmat, S. S. and Shovitri, M. (2021) ‘Studi Literatur Tentng Teknik Liofilisasi Untuk Preservasi Bakteri’, Jurnal Teknik ITS, 10(2), pp. 17–22.
Sagala, R. J. (2019) ‘Review: Metode Peningkatan Kecepatan Disolusi Dikombinasi Dengan Penambahan Surfaktan’, Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal), 5(1), pp. 84–92. doi: 10.22487/j24428744.2019.v5.i1.12360.
Santosa, D. M. and Pertiwi, F. D. (2020) ‘Formulasi dan Uji Disolusi Terbanding Tablet Lepas Lambat Natrium Diklofenak Menggunakan Methocel K100M Sebagai Matriks’, Indonesia Natural Research Pharmaceutical Journal, 5(2), pp. 1–11.
Setyawan, D., Wardhana, N. K. and Sari, R. (2015) ‘Solubility, Dissolution Test And Antimalarial Activity Of Artesunate Nicotinamide Co-Crystal Prepared By Solvent Evaporation And Slurry Methods’, Asian Journal of Pharmaceutical and Clinical Research, 8(2), pp. 164–166.
Sharma, A. and Jain, C. P. (2010) ‘Preparation And Characterization Of Solid Dispersions Of Carvedilol with PVP K30’, Research in Pharmaceutical Sciences, 5(1), pp. 49–56. Available at: http://scholarsresearchlibrary.com/ABR-vol1-iss2/ABR-2010-1-2-87-90.pdf.
Shinde, A., Jadhav, N., Shinde, O., & Patil, P. (2019) ‘Enhancement Solubility And Dissolution Rate Of Paracetamol And Ibuprofen By Coamorphous Particles Using Microwave Technique’, Asian Journal of Pharmaceutical and Clinical Research, 12(11), pp. 155–162. doi: 10.22159/ajpcr.2019.v12i11.34589.
Siswanto, A., Fudholi, A., Nugroho, A. K., & Martono, S. (2014) ‘Pengaruh Medium Dissolusi dan Penggunaan Sinker Terhadap Profil Disolusi Tablet Floating Aspirin’, Pharmacy, 11(02), pp. 1–10.
Sitompul, E. D. and Dharma, S. (2018) ‘Pengaruh Variasi Konsentrasi Media Pendingin (Quenchant) Pada Proses Quench Terhadap Kekerasan, Struktur Mikro Dan Retak Akibat Quench (Quench Crack) Dari Baja AISI 1040’, Jurnal ROTOR, 11(1), pp. 1–7.
Skotnicki, M., Jadach, B., Skotnicka, A., Milanowski, B., Tajber, L., Pyda, M., & Kujawski, J. (2021) ‘Physicochemical Characterization Of a Co-Amorphous Atorvastatin-Irbesartan System With a Potential Application In Fixed-Dose Combination Therapy’, Pharmaceutics, 13(1), pp. 1–20. doi: 10.3390/pharmaceutics13010118.
Sutiswa, S. I., Cahyati, Y. and Mudhakir, D. (2019) ‘Peningkatan Disolusi Rosuvastatin Calsium dari Sediaan Tablet dengan Teknik Liquisolid dan Pembentukan Kompleks Inklusi’, Jurnal Riset Kefarmasian Indonesia, 1(2), pp. 93–102. doi: 10.33759/jrki.v1i2.21.
Wardana, D., Ramadhan, A., Fitri Amne, D. P., & Eddiyanto. (2019) ‘Utilization of Glycerol from Used Oil as an Ester Glycerol Surfactant’, Indonesian Journal of Chemical Science and Technology (IJCST), 2(2), pp. 111–120. doi: 10.24114/ijcst.v2i2.13999.
Published
2024-01-31
How to Cite
RIZQI, Syifa Maulidia; CHABIB, Lutfi.
Comparative Methods of Increasing Drug Dissolution Rate.
Jurnal Farmasi Udayana, [S.l.], p. 88-93, jan. 2024.
ISSN 2622-4607.
Available at: <https://ojs.unud.ac.id/index.php/jfu/article/view/96740>. Date accessed: 05 nov. 2024.
doi: https://doi.org/10.24843/JFU.2023.v12.i02.p02.
Section
Articles
