Review Artikel : Kandungan Fitokimia dan Potensi Urang Aring (Eclipta alba L.) Sebagai Bahan Baku Obat Untuk Mengatasi Kebotakan (Hair Loss)
Abstract
Urang-Aring (Eclipta alba L.) belongs to the genus Eclipta from the Asteraceae family. This plant has been used for generations as traditional medicine and is known to have various pharmacological activities. In this review, we discuss the in vivo testing of several extracts from the urang-aring in mice, the phytochemical compounds contained and the pharmacological activity of the urang-aring extract. The results showed that the ethanol extract, petroleum ether and ethyl acetate fraction of the methanol extract from this plant were reported to have hair growth-promoting activity. Many research studies report that there are various types of phytochemical compounds such as triterpenes, saponins, flavonoids, thiophene, kumestan, coumarins and steroids in this plant. Among these compounds, wedelolactone and ?-sitosterol are considered to be responsible for their pharmacological activity in overcoming hair loss. Wedelolactone is known to have the activity of inhibiting the expression of TGF-?1 resulting in the elongation of hair follicles. Meanwhile, ?-sitosterol works as a 5?-reductase inhibitor so that it contributes to the treatment of androgenic alopecia.
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References
Begum, S., Lee, M. R., Gu, L. J., Hossain, J., & Sung, C. K. (2015). Exogenous stimulation with Eclipta alba promotes hair matrix keratinocyte proliferation and downregulates TGF-β1 expression in nude mice. International Journal of Molecular Medicine, 35(2), 496–502. https://doi.org/10.3892/IJMM.2014.2022
Begum, S., Lee, M. R., Gu, L. J., Hossain, M. J., Kim, H. K., & Sung, C. K. (2014). Comparative hair restorer efficacy of medicinal herb on nude (Foxn1nu) mice. BioMed Research International, 2014. https://doi.org/10.1155/2014/319795
Chaudhary, J., Jain, A., Kaur, N., & Kishore, L. (2011). Stigmasterol: A Comprehensive Review “Pharmacological Investigation of Some Indian Herbal Medicinal Plants in Treatment of Diabetes and its Complications” View project STIGMASTEROL: A COMPREHENSIVE REVIEW. Article in International Journal of Pharmaceutical Sciences and Research, 2(9). https://www.researchgate.net/publication/264420218
Chung, I. M., Rajakumar, G., Lee, J. H., Kim, S. H., & Thiruvengadam, M. (2017). Ethnopharmacological uses, phytochemistry, biological activities, and biotechnological applications of Eclipta prostrata. In Applied Microbiology and Biotechnology (Vol. 101, Issue 13, pp. 5247–5257). Springer Verlag. https://doi.org/10.1007/s00253-017-8363-9
Datta, K., Rohil, V., Singh, A. T., Mukherjee, A., Bhat, B., & Ramesh, B. (2012). Eclipta alba Extract with Potential for Reversing Chemotherapy-induced Alopecia: An Experimental Study in Mice. Ann Natl Acad Med Sci, 48(4), 43–64.
Datta, K., Singh, A. T., Mukherjee, A., Bhat, B., Ramesh, B., & Burman, A. C. (2009). Eclipta alba extract with potential for hair growth promoting activity. Journal of Ethnopharmacology, 124(3), 450–456. https://doi.org/10.1016/J.JEP.2009.05.023
DJPEN. (2014). OBAT HERBAL TRADISIONAL. In Warta Ekspor: Vol. September (pp. 1–20). Direktorat Jenderal Pengembangan Ekspor Nasional Kementrian Perdagangan.
Ekor, M., & Pistelli, L. (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology, 4(177), 1–10. https://doi.org/10.3389/fphar.2013.00177
Epstein, G. K., Epstein, J., & Cohen, J. (2019). Hair Loss in Men and Women : Medical and Surgical Therapies. Advances in Cosmetic Surgery, 2(1), 161–176. https://doi.org/10.1016/j.yacs.2019.02.006
Feng, L., Zhai, Y. Y., Xu, J., Yao, W. F., Cao, Y. D., Cheng, F. F., Bao, B. H., & Zhang, L. (2019). A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L. Journal of Ethnopharmacology, 245, 112109. https://doi.org/10.1016/J.JEP.2019.112109
Mukhopadhyay, G., Kundu, S., Sarkar, A., Sarkar, P., Sengupta, R., & Kumar, C. (2018). A review on physicochemical & pharmacological activity of Eclipta alba. The Pharma Innovation Journal, 7(9), 78–83. www.thepharmajournal.com
Hamblin, M. R. (2018). Alopecia. In Conn’s Handbook of Models for Human Aging (pp. 751–762). Elsevier. https://doi.org/10.1016/B978-0-12-811353-0.00055-5
Han, L., Zhao, J., Zhang, Y., Kojo, A., Liu, E., & Wang, T. (2013). Chemical Constituents from Dried Aerial Parts of Eclipta prostrata. Chinese Herbal Medicines, 5(4), 313–316. https://doi.org/10.1016/S1674-6384(13)60047-7
Herman, A., & Herman, A. P. (2016). Mechanism of action of herbs and their active constituents used in hair loss treatment. Fitoterapia, 114, 18–25. https://doi.org/10.1016/J.FITOTE.2016.08.008
Jahan, R., Al-Nahain, A., Majumder, S., & Rahmatullah, M. (2014). Ethnopharmacological significance of Eclipta alba (L.) hassk.(Asteraceae). International Scholarly Research Notices, 1–22. https://doi.org/10.1155/2014/385969
Khurshid, R., Khan, T., Zaeem, A., Garros, L., Hano, C., & Abbasi, B. H. (2018). Biosynthesis of precious metabolites in callus cultures of Eclipta alba. Plant Cell, Tissue and Organ Culture, 135(2), 287–298. https://doi.org/10.1007/s11240-018-1463-0
Kim, H. Y., Kim, H. M., Ryu, B., Lee, J. S., Choi, J. H., & Jang, D. S. (2015). Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro. Archives of Pharmacal Research, 38(11), 1963–1969. https://doi.org/10.1007/S12272-015-0599-2
Le, D. D., Nguyen, D. H., Ma, E. S., Lee, J. H., Min, B. S., Choi, J. S., & Woo, M. H. (2021). PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from Eclipta prostrata L. Biological & Pharmaceutical Bulletin, 44(3), 298–304. https://doi.org/10.1248/BPB.B20-00994
Lee, C. S., Kang, J. A., Kim, G. Y., & Kim, G. R. (2020). A study on the effect of eclipta prostrata extract and mts on the improvement of scalp health and prevention of hair loss for workers in their 20s and 30s. Medico-Legal Update, 20(1), 1850–1856. https://doi.org/10.37506/v20/i1/2020/mlu/194573
Li, S., Chen, J., Chen, F., Wang, C., Guo, X., Wang, C., Fan, Y., Wang, Y., Peng, Y., & Li, W. (2021). Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice. Biomedicine and Pharmacotherapy, 141. https://doi.org/10.1016/J.BIOPHA.2021.111793
Li, W., Pang, X., Han, L. F., Zhou, Y., & Cui, Y. M. (2018). Chemcial constituents of Eclipta prostrata. China Journal of Chinese Materia Medica, 43(17), 3498–3505. https://doi.org/10.19540/J.CNKI.CJCMM.20180625.001
Liu, Q. M., Zhao, H. Y., Zhong, X. K., & Jiang, J. G. (2012). Eclipta prostrata L. phytochemicals: Isolation, structure elucidation, and their antitumor activity. Food and Chemical Toxicology, 50(11), 4016–4022. https://doi.org/10.1016/J.FCT.2012.08.007
Mondal, S., Debjit, G., Seru, G., & M. Sushrutha. (2016). Preliminary phytochemical analysis and evaluation of hair growth stimulating potential of ethanol extract from Eclipta alba L. (Asteraceae) leaves in Wistar albino rats. Asian Journal of Pharmacy and Pharmacology, 2(5), 121–127.
Monteiro Espíndola, K. M., Ferreira, R. G., Mosquera Narvaez, L. E., Rocha Silva Rosario, A. C., Machado Da Silva, A. H., Bispo Silva, A. G., Oliveira Vieira, A. P., & Chagas Monteiro, M. (2019). Chemical and pharmacological aspects of caffeic acid and its activity in hepatocarcinoma. Frontiers in Oncology, 9(JUN). https://doi.org/10.3389/fonc.2019.00541
Morel, L. J. de F., Azevedo, B. C. de, Carmona, F., Contini, S. H. T., Teles, A. M., Ramalho, F. S., Bertoni, B. W., França, S. de C., Borges, M. de C., & Pereira, A. M. S. (2017). A standardized methanol extract of Eclipta prostrata (L.) L. (Asteraceae) reduces bronchial hyperresponsiveness and production of Th2 cytokines in a murine model of asthma. Journal of Ethnopharmacology, 198, 226–234. https://doi.org/10.1016/J.JEP.2016.12.008
Phillips, T. G., Slomiany, W. P., & Allison, R. (2017). Hair Loss: Common Causes and Treatment. Am Fam Physician, 96(6), 371–378. https://www.aafp.org/pubs/afp/issues/2017/0915/p371.html
Premanand, A., Ancy, V. B., Jeevanandam, J., Rajkumari, B. R., & Danquah, M. K. (2019). Phytochemicals as emerging therapeutic agents for alopecia treatment. Phytochemicals as Lead Compounds for New Drug Discovery, 221–238. https://doi.org/10.1016/B978-0-12-817890-4.00014-7
Regupathi, T., Chitra, K., Ruckmani, K., Lalitha4, K. G., & Kumar, M. (2017). Pharmacology & Clinical Research Formulation and Evaluation of Herbal Hair Gel for Hair Growth Potential. Journal of Pharmacology & Clinical Research, 2(2), 1–8. https://doi.org/10.19080/JPCR.2017.02.555581
Roy, R. K., Thakur, M., & Dixit, V. K. (2008). Hair growth promoting activity of Eclipta alba in male albino rats. Archives of Dermatological Research, 300(7), 357–364. https://doi.org/10.1007/S00403-008-0860-3
Sherchan, J., Poudel, P., Sapkota, B., Jan, H. A., & Bussmann, R. W. (2021). Eclipta prostrata (L.) L. Asteraceae. In Ethnobotany of Mountain Regions Series Editors: Ethnobotany of the Himalayas (pp. 835–853). https://doi.org/10.1007/978-3-030-57408-6_89
Timalsina, D., & Devkota, H. P. (2021). Eclipta prostrata (L.) L. (Asteraceae): Ethnomedicinal Uses, Chemical Constituents, and Biological Activities. Biomolecules, 11(11). https://doi.org/10.3390/BIOM11111738
Trüeb, R. M. (2015). The Difficult Hair Loss Patient : Guide to Successful management of Alopecia and Related Conditions. Springer International Publishing.
Vinyagam, R., Kumar, P., Lee, K. E., Xu, B., Matin, M. N., & Kang, S. G. (2020). Biological and functional properties of wedelolactone in human chronic diseases. Phyton, 90(1), 1–15. https://doi.org/10.32604/phyton.2020.013388
Weaver, L. J., Krupp, K., & Madhivanan, P. (2022). The Hair in the Garland: Hair Loss and Social Stress Among Women in South India. Culture, Medicine and Psychiatry, 46(2), 456–474. https://doi.org/10.1007/s11013-021-09725-6
Xi, F. M., Li, C. T., Han, J., Yu, S. S., Wu, Z. J., & Chen, W. S. (2014a). Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrata. Bioorganic and Medicinal Chemistry, 22(22), 6515–6522. https://doi.org/10.1016/J.BMC.2014.06.051
Xi, F. M., Li, C. T., Mi, J. L., Wu, Z. J., & Chen, W. S. (2014b). Three new olean-type triterpenoid saponins from aerial parts of Eclipta prostrata (L.). Natural Product Research, 28(1), 35–40. https://doi.org/10.1080/14786419.2013.832674
Xiong, H. P., Xi, F. M., Chen, W. S., Lu, W. Q., & Wu, Z. J. (2021). Chemical Constituents of Eclipta prostrata. Chemistry of Natural Compounds, 57(1), 166–168. https://doi.org/10.1007/s10600-021-03308-y
Yadav, N. K., Arya, R. K., Dev, K., Sharma, C., Hossain, Z., Meena, S., Arya, K. R., Gayen, J. R., Datta, D., & Singh, R. K. (2017). Alcoholic extract of eclipta alba shows in vitro antioxidant & anticancer activity without exhibiting toxicological effects. Oxidative Medicine and Cellular Longevity, 2017. https://doi.org/10.1155/2017/9094641
Yu, S. J., Yu, J. H., Yu, Z. P., Yan, X., Zhang, J. S., Sun, J. yue, & Zhang, H. (2020). Bioactive terpenoid constituents from Eclipta prostrata. Phytochemistry, 170, 112192. https://doi.org/10.1016/J.PaHYTOCHEM.2019.112192
Begum, S., Lee, M. R., Gu, L. J., Hossain, M. J., Kim, H. K., & Sung, C. K. (2014). Comparative hair restorer efficacy of medicinal herb on nude (Foxn1nu) mice. BioMed Research International, 2014. https://doi.org/10.1155/2014/319795
Chaudhary, J., Jain, A., Kaur, N., & Kishore, L. (2011). Stigmasterol: A Comprehensive Review “Pharmacological Investigation of Some Indian Herbal Medicinal Plants in Treatment of Diabetes and its Complications” View project STIGMASTEROL: A COMPREHENSIVE REVIEW. Article in International Journal of Pharmaceutical Sciences and Research, 2(9). https://www.researchgate.net/publication/264420218
Chung, I. M., Rajakumar, G., Lee, J. H., Kim, S. H., & Thiruvengadam, M. (2017). Ethnopharmacological uses, phytochemistry, biological activities, and biotechnological applications of Eclipta prostrata. In Applied Microbiology and Biotechnology (Vol. 101, Issue 13, pp. 5247–5257). Springer Verlag. https://doi.org/10.1007/s00253-017-8363-9
Datta, K., Rohil, V., Singh, A. T., Mukherjee, A., Bhat, B., & Ramesh, B. (2012). Eclipta alba Extract with Potential for Reversing Chemotherapy-induced Alopecia: An Experimental Study in Mice. Ann Natl Acad Med Sci, 48(4), 43–64.
Datta, K., Singh, A. T., Mukherjee, A., Bhat, B., Ramesh, B., & Burman, A. C. (2009). Eclipta alba extract with potential for hair growth promoting activity. Journal of Ethnopharmacology, 124(3), 450–456. https://doi.org/10.1016/J.JEP.2009.05.023
DJPEN. (2014). OBAT HERBAL TRADISIONAL. In Warta Ekspor: Vol. September (pp. 1–20). Direktorat Jenderal Pengembangan Ekspor Nasional Kementrian Perdagangan.
Ekor, M., & Pistelli, L. (2014). The growing use of herbal medicines: issues relating to adverse reactions and challenges in monitoring safety. Frontiers in Pharmacology, 4(177), 1–10. https://doi.org/10.3389/fphar.2013.00177
Epstein, G. K., Epstein, J., & Cohen, J. (2019). Hair Loss in Men and Women : Medical and Surgical Therapies. Advances in Cosmetic Surgery, 2(1), 161–176. https://doi.org/10.1016/j.yacs.2019.02.006
Feng, L., Zhai, Y. Y., Xu, J., Yao, W. F., Cao, Y. D., Cheng, F. F., Bao, B. H., & Zhang, L. (2019). A review on traditional uses, phytochemistry and pharmacology of Eclipta prostrata (L.) L. Journal of Ethnopharmacology, 245, 112109. https://doi.org/10.1016/J.JEP.2019.112109
Mukhopadhyay, G., Kundu, S., Sarkar, A., Sarkar, P., Sengupta, R., & Kumar, C. (2018). A review on physicochemical & pharmacological activity of Eclipta alba. The Pharma Innovation Journal, 7(9), 78–83. www.thepharmajournal.com
Hamblin, M. R. (2018). Alopecia. In Conn’s Handbook of Models for Human Aging (pp. 751–762). Elsevier. https://doi.org/10.1016/B978-0-12-811353-0.00055-5
Han, L., Zhao, J., Zhang, Y., Kojo, A., Liu, E., & Wang, T. (2013). Chemical Constituents from Dried Aerial Parts of Eclipta prostrata. Chinese Herbal Medicines, 5(4), 313–316. https://doi.org/10.1016/S1674-6384(13)60047-7
Herman, A., & Herman, A. P. (2016). Mechanism of action of herbs and their active constituents used in hair loss treatment. Fitoterapia, 114, 18–25. https://doi.org/10.1016/J.FITOTE.2016.08.008
Jahan, R., Al-Nahain, A., Majumder, S., & Rahmatullah, M. (2014). Ethnopharmacological significance of Eclipta alba (L.) hassk.(Asteraceae). International Scholarly Research Notices, 1–22. https://doi.org/10.1155/2014/385969
Khurshid, R., Khan, T., Zaeem, A., Garros, L., Hano, C., & Abbasi, B. H. (2018). Biosynthesis of precious metabolites in callus cultures of Eclipta alba. Plant Cell, Tissue and Organ Culture, 135(2), 287–298. https://doi.org/10.1007/s11240-018-1463-0
Kim, H. Y., Kim, H. M., Ryu, B., Lee, J. S., Choi, J. H., & Jang, D. S. (2015). Constituents of the aerial parts of Eclipta prostrata and their cytotoxicity on human ovarian cancer cells in vitro. Archives of Pharmacal Research, 38(11), 1963–1969. https://doi.org/10.1007/S12272-015-0599-2
Le, D. D., Nguyen, D. H., Ma, E. S., Lee, J. H., Min, B. S., Choi, J. S., & Woo, M. H. (2021). PTP1B Inhibitory and Anti-inflammatory Properties of Constituents from Eclipta prostrata L. Biological & Pharmaceutical Bulletin, 44(3), 298–304. https://doi.org/10.1248/BPB.B20-00994
Lee, C. S., Kang, J. A., Kim, G. Y., & Kim, G. R. (2020). A study on the effect of eclipta prostrata extract and mts on the improvement of scalp health and prevention of hair loss for workers in their 20s and 30s. Medico-Legal Update, 20(1), 1850–1856. https://doi.org/10.37506/v20/i1/2020/mlu/194573
Li, S., Chen, J., Chen, F., Wang, C., Guo, X., Wang, C., Fan, Y., Wang, Y., Peng, Y., & Li, W. (2021). Liposomal honokiol promotes hair growth via activating Wnt3a/β-catenin signaling pathway and down regulating TGF-β1 in C57BL/6N mice. Biomedicine and Pharmacotherapy, 141. https://doi.org/10.1016/J.BIOPHA.2021.111793
Li, W., Pang, X., Han, L. F., Zhou, Y., & Cui, Y. M. (2018). Chemcial constituents of Eclipta prostrata. China Journal of Chinese Materia Medica, 43(17), 3498–3505. https://doi.org/10.19540/J.CNKI.CJCMM.20180625.001
Liu, Q. M., Zhao, H. Y., Zhong, X. K., & Jiang, J. G. (2012). Eclipta prostrata L. phytochemicals: Isolation, structure elucidation, and their antitumor activity. Food and Chemical Toxicology, 50(11), 4016–4022. https://doi.org/10.1016/J.FCT.2012.08.007
Mondal, S., Debjit, G., Seru, G., & M. Sushrutha. (2016). Preliminary phytochemical analysis and evaluation of hair growth stimulating potential of ethanol extract from Eclipta alba L. (Asteraceae) leaves in Wistar albino rats. Asian Journal of Pharmacy and Pharmacology, 2(5), 121–127.
Monteiro Espíndola, K. M., Ferreira, R. G., Mosquera Narvaez, L. E., Rocha Silva Rosario, A. C., Machado Da Silva, A. H., Bispo Silva, A. G., Oliveira Vieira, A. P., & Chagas Monteiro, M. (2019). Chemical and pharmacological aspects of caffeic acid and its activity in hepatocarcinoma. Frontiers in Oncology, 9(JUN). https://doi.org/10.3389/fonc.2019.00541
Morel, L. J. de F., Azevedo, B. C. de, Carmona, F., Contini, S. H. T., Teles, A. M., Ramalho, F. S., Bertoni, B. W., França, S. de C., Borges, M. de C., & Pereira, A. M. S. (2017). A standardized methanol extract of Eclipta prostrata (L.) L. (Asteraceae) reduces bronchial hyperresponsiveness and production of Th2 cytokines in a murine model of asthma. Journal of Ethnopharmacology, 198, 226–234. https://doi.org/10.1016/J.JEP.2016.12.008
Phillips, T. G., Slomiany, W. P., & Allison, R. (2017). Hair Loss: Common Causes and Treatment. Am Fam Physician, 96(6), 371–378. https://www.aafp.org/pubs/afp/issues/2017/0915/p371.html
Premanand, A., Ancy, V. B., Jeevanandam, J., Rajkumari, B. R., & Danquah, M. K. (2019). Phytochemicals as emerging therapeutic agents for alopecia treatment. Phytochemicals as Lead Compounds for New Drug Discovery, 221–238. https://doi.org/10.1016/B978-0-12-817890-4.00014-7
Regupathi, T., Chitra, K., Ruckmani, K., Lalitha4, K. G., & Kumar, M. (2017). Pharmacology & Clinical Research Formulation and Evaluation of Herbal Hair Gel for Hair Growth Potential. Journal of Pharmacology & Clinical Research, 2(2), 1–8. https://doi.org/10.19080/JPCR.2017.02.555581
Roy, R. K., Thakur, M., & Dixit, V. K. (2008). Hair growth promoting activity of Eclipta alba in male albino rats. Archives of Dermatological Research, 300(7), 357–364. https://doi.org/10.1007/S00403-008-0860-3
Sherchan, J., Poudel, P., Sapkota, B., Jan, H. A., & Bussmann, R. W. (2021). Eclipta prostrata (L.) L. Asteraceae. In Ethnobotany of Mountain Regions Series Editors: Ethnobotany of the Himalayas (pp. 835–853). https://doi.org/10.1007/978-3-030-57408-6_89
Timalsina, D., & Devkota, H. P. (2021). Eclipta prostrata (L.) L. (Asteraceae): Ethnomedicinal Uses, Chemical Constituents, and Biological Activities. Biomolecules, 11(11). https://doi.org/10.3390/BIOM11111738
Trüeb, R. M. (2015). The Difficult Hair Loss Patient : Guide to Successful management of Alopecia and Related Conditions. Springer International Publishing.
Vinyagam, R., Kumar, P., Lee, K. E., Xu, B., Matin, M. N., & Kang, S. G. (2020). Biological and functional properties of wedelolactone in human chronic diseases. Phyton, 90(1), 1–15. https://doi.org/10.32604/phyton.2020.013388
Weaver, L. J., Krupp, K., & Madhivanan, P. (2022). The Hair in the Garland: Hair Loss and Social Stress Among Women in South India. Culture, Medicine and Psychiatry, 46(2), 456–474. https://doi.org/10.1007/s11013-021-09725-6
Xi, F. M., Li, C. T., Han, J., Yu, S. S., Wu, Z. J., & Chen, W. S. (2014a). Thiophenes, polyacetylenes and terpenes from the aerial parts of Eclipata prostrata. Bioorganic and Medicinal Chemistry, 22(22), 6515–6522. https://doi.org/10.1016/J.BMC.2014.06.051
Xi, F. M., Li, C. T., Mi, J. L., Wu, Z. J., & Chen, W. S. (2014b). Three new olean-type triterpenoid saponins from aerial parts of Eclipta prostrata (L.). Natural Product Research, 28(1), 35–40. https://doi.org/10.1080/14786419.2013.832674
Xiong, H. P., Xi, F. M., Chen, W. S., Lu, W. Q., & Wu, Z. J. (2021). Chemical Constituents of Eclipta prostrata. Chemistry of Natural Compounds, 57(1), 166–168. https://doi.org/10.1007/s10600-021-03308-y
Yadav, N. K., Arya, R. K., Dev, K., Sharma, C., Hossain, Z., Meena, S., Arya, K. R., Gayen, J. R., Datta, D., & Singh, R. K. (2017). Alcoholic extract of eclipta alba shows in vitro antioxidant & anticancer activity without exhibiting toxicological effects. Oxidative Medicine and Cellular Longevity, 2017. https://doi.org/10.1155/2017/9094641
Yu, S. J., Yu, J. H., Yu, Z. P., Yan, X., Zhang, J. S., Sun, J. yue, & Zhang, H. (2020). Bioactive terpenoid constituents from Eclipta prostrata. Phytochemistry, 170, 112192. https://doi.org/10.1016/J.PaHYTOCHEM.2019.112192
Published
2024-01-31
How to Cite
ANGGA PURNAMA, Dewa Julio; DEWI, Ni Luh Putu Putri.
Review Artikel : Kandungan Fitokimia dan Potensi Urang Aring (Eclipta alba L.) Sebagai Bahan Baku Obat Untuk Mengatasi Kebotakan (Hair Loss).
Jurnal Farmasi Udayana, [S.l.], p. 81-87, jan. 2024.
ISSN 2622-4607.
Available at: <https://ojs.unud.ac.id/index.php/jfu/article/view/90017>. Date accessed: 23 nov. 2024.
doi: https://doi.org/10.24843/JFU.2023.v12.i02.p01.
Section
Articles
