Potensi Senyawa Aktif Tanaman Herbal untuk Pengobatan Kanker Payudara dengan Metode Penambatan Molekuler: Review Artikel
POTENSI SENYAWA AKTIF TANAMAN HERBAL UNTUK PENGOBATAN KANKER PAYUDARA DENGAN METODE PENAMBATAN MOLEKULER: REVIEW ARTIKEL
Abstract
Breast cancer is one of the leading causes of death in women worldwide. Breast cancer can be triggered due to physical, chemical, environmental factors and can be passed down from generation to generation through genetics. Therefore, recently, studies have been intensively conducted on the use of medicinal plants for the treatment of breast cancer as an alternative because they have minimal side effects compared to other chemotherapy. This review aims to describe medicinal plants and their active compounds that have the potential as anticancer therapy which has been carried out in silico studies with molecular anchoring methods. The method used in writing this article is a literature review both nationally and internationally over the last five years using the keywords breast cancer, molecular docking, herbal plants, anticancer, in databases such as PubMed, Cochrane, and Google Scholar. Herbal plants in in silico research that have high potential for further research as cancer therapy include 33 herbal plants with different active compounds and protein targets.
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References
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Dona, R. et al. 2019. Studi In Silico, Sintesis, dan Uji Sitotoksik Senyawa P-Metoksi Kalkon Terhadap Sel Kanker Payudara MCF-7. Jurnal Sains Farmasi & Klinis Vol. 6(3): 243-249
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El-Hakim, A., Kinasih, A., Putri, R., Putri, S. U., Kurniawan, F. Y., & Semiarti, E. 2021. In Silico Study of Secondary Metabolite in Vanilla planifolia to inhibit NUDT5 as Breast Cancer Target. Nusantara Science and Technology Proceedings pp. 31-37.
Ernawati, T. 2019. Molecular Docking Simulation of Cinchona Alkaloids Derivatives as Anti-cancer Agent. Indonesian Journal of Pharmaceutical Science and Technology Vol. 1(2): 9-16.
Febriansah, R., & Dewayanti, I. A. 2021. Chemopreventive Activity of Clinacanthus nutans L. Ethyl Acetate Fraction on Breast Cancer Cells Line. In 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020) (pp. 520-527). Atlantis Press.
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Hakim, A., S, W. & Alfianto, U., 2018. Hubungan antara Obesitas dengan Reseptor Hormonal (Reseptor Estrogen dan Progesteron dan Ekspresi HER-2/Neu pada Pasien Kanker Payudara di RS X Surakarta. Biomedika Vol. 10(1): 30-34.
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Kartika, I. G. A. A., Bang, I. J., Riani, C., Insanu, M., Kwak, J. H., Chung, K. H., & Adnyana, I. K. 2020. Isolation And Characterization Of Phenylpropanoid And Lignan Compounds From Peperomia Pellucida [L.] Kunth With Estrogenic Activities. Molecules Vol. 25(21): 4914.
Komari, N., Adawiyah, R., & Suhartono, E. 2022. Evaluasi Molecular Docking Senyawa Mangiferin Dari Buah Kasturi (Mangifera Casturi) Sebagai Antikanker Payudara. In Prosiding Seminar Nasional Lingkungan Lahan Basah Vol 7(1)
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Laksmiani, N. P. L., Widiastari, M. I., & Reynaldi, K. R. 2018. The Inhibitory Activity Of Peonidin Purple Sweet Potato In Human Epidermal Receptor-2 Receptor (Her-2) Expression By In Silico Study. In Journal of Physics: Conference Series (Vol. 1040, No. 1, p. 012010). IOP Publishing.
Mardianingrum, R., Bachtiar, K. R., Susanti, S., Nuraisah, A. N. A., & Ruswanto, R. (2021). Studi In Silico Senyawa 1, 4-Naphthalenedione-2-Ethyl-3-Hydroxy sebagai Antiinflamasi dan Antikanker Payudara. Alchemy Jurnal Penelitian Kimia Vol. 17(1): 83-95
Marisa, D., Hayatie, L., Juliati, S., Suhartono, E., & Komari, N. 2021. Molecular Docking Of Phytosterol Compounds From Kelakai (Stenochlaena palustris) as Anti-Breast Cancer. Acta Biochimica Indonesiana Vol. 4(2): 59-59.
Masitha, F. S., & Febriansah, R. (2019). Antioxidant Activity from the Combination of Ethanolic Extract of Tea Leaves (Camellia sinensis) and Soursop Leaves (Annona muricata l.) and Optimation of the Effervescent Granule Production. Mutiara Medika: Jurnal Kedokteran Dan Kesehatan, 19(2), 56-63.
Mohtar, K., Fatimawali, F., Rumondor, E. M., Datu, O. S., & Tallei, T. E. (2021). Studi In Silico Senyawa Eugenol Cengkeh (Syzygium Aromaticum L.) Terhadap Reseptor Er-Α, Er-Β Dan Her-2 Pada Kanker Payudara. Pharmacon Vol. 10(3): 1001-1008.
Mohapatra, S. S., Dash, A. & Jena, M. K., 2018. Receeptors Associated with Pathogenesis of Breast Cancer: A Mini-Review. Journal of emerging Technologies and Innovative Research (JETIR) Vol. 5(11):. 143-153
Mulyati, B. (2019). Peran Genestein Pada Pengikatan Reseptor Estrogen α. Jurnal Industri Elektro dan Penerbangan Vol. 8(2).
Muslimah, N. H., Wijayanti, R. N., Putriarti, D., Lailiyyah, H., & Purnama, E. R. (2022). Prediksi Interaksi Senyawa Aktif Bidara (Ziziphus Mauritiana) Sebagai Antikanker Terhadap Protein Her2. Stigma: Jurnal Matematika Dan Ilmu Pengetahuan Alam Unipa Vol. 15(1): 1-9.
Mylanda, V., Ramadhan, N. E., & Viviani, R. N. 2021. Studi Penambatan Molekuler Senyawa Bioaktif Biji Habbatussauda (Nigella sativa) terhadap ERα sebagai Alternatif Pengobatan Kanker Payudara dalam Upaya Pemberian Data Ilmiah Thibbun Nabawi. Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI) Vol. 8(1): 13-24.
Nitami, S. F., & Febriansah, R. (2019). Penambatan molekular senyawa tangeretin dan kampferol pada protein antiapoptosis Bcl-xL: studi in silico. Acta Pharm Indones, 7(2), 42-50.
Pinanti, H. N., Nafisah, W., Christina, Y. I., Rifa’i, M., & Djati, M. S. 2021. Biflavonoid Compounds From Selaginella Doederleinii Hieron As Anticancer Agents Of Hormone Receptor-Positive (HR+) Breast Cancer Based On In Silico Study. In IOP Conference Series: Earth and Environmental Science (Vol. 743, No. 1, p. 012028). IOP Publishing.
Prasetiawati, R., Permana, B., Soni, D., & Agung, S. N. 2019. Molecular Docking Study Of Xanthone Derivative Compounds Of Mangosteen Rind (Garcinia Mangostana L.) To Er-Α (Estrogen Receptor Alfa) And Er-Β (Estrogen Receptor Beta) As Anti-Breastcancer. Jurnal Ilmiah Farmako Bahari Vol. 10(1): 45-52
Pratama, M. R. F., & Pratomo, G. S. 2017. Pharmacophore optimization of berberine as HER2 inhibitor. Jurnal Farmasi Indonesia Vol. 14(2).
Pratiwi, R. I. A., Rahayu, T., & Mubarakati, N. J. (2020). In Silico Screening of Schleichera oleosa Phytocompounds as Estrogen Receptors Alpha Inhibitors for Breast Cancer. JSMARTech: Journal of Smart Bioprospecting and Technology, 2(1), 014-021.
Rastini, M. B. O., Giantari, N. K. M., Adnyani, K. D. & Laksmiani, N. P. L. 2019. Molecular Docking Aktivitas Antikanker dari Kuersetin terhadap Kanker Payudara secara In Silico. Journal of Chemistry Vol. 13(2): 180-184.
Reynaldi, M. A., & Setiawansyah, A. 2022. Potensi anti-kanker payudara tanaman songga (Strychnos lucida R. Br): Tinjauan interaksi molekuler terhadap reseptor estrogen-α in silico. Sasambo Journal of Pharmacy Vol. 3(1): 30-35.
Rosmalena, R., Prasasty, V. D., Yazid, F., Budianto, E., Elya, B., Lotulung, P., Omar, H., & Hanafi, M. 2021. Isolation, Identification and Synthesis of Neolignans from Phoebe declinata Leaves: Molecular Modeling and Anticancer Evaluation. Systematic Reviews in Pharmacy Vol. 12(1): 1129-1141.
Sethi, A., Joshi, K., Sasikala, K. & Alvala, M., 2019. Molecular Docking in Modern Drug Discovery: Principles and Recent Applications. Drug Discovery and Development-New Advances, pp. 1-21.
Shofi, M. (2021). Studi In Silico Senyawa Kuarsetin Daun Kencana Ungu (Ruellia Tuberosa L.) Sebagai Agen Antikanker Payudara. Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya, 2(1), 1-9.
Sianipar, N. F., Hadisaputri, Y. E., Assidqi, K., Salam, S., Yusuf, M., Destiarani, W., Purnamaningsih, R., & So, I. G. 2021. Characterization and Investigation of Stigmasterol Isolated from Rodent Tuber Mutant Plant (Typhonium flagelliforme), Its Molecular Docking as Anticancer on MF-7 Cells. Preprints 2021.
Sozianty, D., & Febriansah, R. 2020. Cytotoxic activity and selectivity index of binahong (Anredera cordifolia) extracts on MCF-7 breast cancer cells and vero normal cells line. Acta Biochimica Indonesiana Vol. 3(2): 72-80.
Suherlan, S., Rohayah & Fakih, T. M., 2021. Uji Aktivitas Antikanker Payudara Senyawa Andrografolida dari Tumbuhan Sambiloto (Andrographis paniculata (Burm F) Ness.) terhadap Human Epidermal Growth Factor Receptor 2 (HER-2) secara In Silico. Jurnal Ilmu Farmasi Farmasyifa Vol. 4(2): 39-50.
Supriyanto, S., Rifa'i, M., Yunianta, Y., & Widjanarko, S. B. 2020. Potential Use of Compounds from Neem Leaves (Azadirachta indica Juss) as PPARg and ERa Inhibitors to Control Breast Cancer Cell Growth In Silico Model. ALCHEMY Vol. 8(1): 18-22.
Syahputra, G., Ambarsari, L., & Sumaryada, T. 2014. Simulasi Docking Kurkumin Enol, Bisdemetoksikurkumin Dan Analognya Sebagai Inhibitor Enzim12-Lipoksigenase. Jurnal Biofisika Vol. 10(1).
The Global Cancer Observatory, 2021. Indonesia. Geneva: World Health Organization.
Yusharyahya, S. N., Bramono, K., Ascobat, P., Hestiantoro, A., Sutanto, N. R., & Fadilah, F. 2019. In silico molecular docking and pharmacophore modelling studies of Trigonella foenum-graceum (fenugreek) interactions with estrogen receptors α and β. Journal of Pharmaceutical Sciences and Research Vol. 11(12): 3705-3711.
Zhou, Z., Qiao, J. X., Shetty, A., Wu, G., Huang, Y., Davidson, N. E., & Wan, Y. 2014. Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy. Cellular and molecular life sciences: CMLS Vol. 71(8): 1549.
Ardiana, R., Dewi, U. K., Diah, P., & Oktavia, R. A. 2020. Molecular docking study of active compounds in Amaranthus tricolor leaves as high mobility group box 1 (HMB1) inhibitor in breast cancer. Journal of Smart Bioprospecting and Technology Vol. 2(1)
Chaudhary, K. K., & Mishra, N. 2016. A review on molecular docking: novel tool for drug discovery. Databases Vol. 3(4): 1029.
Christina. Y. I., Nafisah, W., Atho’illah, M. F., Rifa’i, M., Widodo, N., & Djati, S. 2021) Anti-breast cancer potential activity of Phaleria macrocarpa (Scheff.) Boerl. leaf extract through in silico studies. Journal of Pharmacy & Pharmacognosy Research Vol. 9(6): 824-845.
Dona, R. et al. 2019. Studi In Silico, Sintesis, dan Uji Sitotoksik Senyawa P-Metoksi Kalkon Terhadap Sel Kanker Payudara MCF-7. Jurnal Sains Farmasi & Klinis Vol. 6(3): 243-249
Dwirosalia, D., Yustisia, I., Arsyad, A., Husni Cangara, M., Patellongi, I., & Natsir, R. 2021. Studi In Silico Potensi Anti Kanker Senyawa Turunan Kumarin Terhadap Protein Bcl-2. Majalah Farmasi Dan Farmakologi Vol. 25(2): 80-83.
El-Hakim, A., Kinasih, A., Putri, R., Putri, S. U., Kurniawan, F. Y., & Semiarti, E. 2021. In Silico Study of Secondary Metabolite in Vanilla planifolia to inhibit NUDT5 as Breast Cancer Target. Nusantara Science and Technology Proceedings pp. 31-37.
Ernawati, T. 2019. Molecular Docking Simulation of Cinchona Alkaloids Derivatives as Anti-cancer Agent. Indonesian Journal of Pharmaceutical Science and Technology Vol. 1(2): 9-16.
Febriansah, R., & Dewayanti, I. A. 2021. Chemopreventive Activity of Clinacanthus nutans L. Ethyl Acetate Fraction on Breast Cancer Cells Line. In 4th International Conference on Sustainable Innovation 2020–Health Science and Nursing (ICoSIHSN 2020) (pp. 520-527). Atlantis Press.
Fitriah, A., Holil, K., Syarifah, U., Fitriyah, & Utomo, D. H. 2018. . Uji Aktivitas Senyawa Panduratin A dan Turunannya terhadap Reseptor Estrogen Alfa pada Kanker Payudara Secara In Silico. In AIP Conference Proceedings (Vol. 2021, No. 1, p. 070003). AIP Publishing LLC.
Hakim, A., S, W. & Alfianto, U., 2018. Hubungan antara Obesitas dengan Reseptor Hormonal (Reseptor Estrogen dan Progesteron dan Ekspresi HER-2/Neu pada Pasien Kanker Payudara di RS X Surakarta. Biomedika Vol. 10(1): 30-34.
Harahap, H. P. & Lumbanraja, S. N. 2018. Faktor Risiko Kanker Payudara pada Wanita Usia Subur di RSUD Dr. Pirngadi Medan. Jurnal Kesehatan Global Vol. 1(1): 8-14.
Jannati, F. A., Wisnuwardhani, H. A., & Fakih, T. M. 2021. Uji Aktivitas Senyawa Panduratin A dan Turunannya terhadap Reseptor Estrogen Alfa pada Kanker Payudara Secara In Silico. Prosiding Farmasi pp. 498-507.
Kartika, I. G. A. A., Bang, I. J., Riani, C., Insanu, M., Kwak, J. H., Chung, K. H., & Adnyana, I. K. 2020. Isolation And Characterization Of Phenylpropanoid And Lignan Compounds From Peperomia Pellucida [L.] Kunth With Estrogenic Activities. Molecules Vol. 25(21): 4914.
Komari, N., Adawiyah, R., & Suhartono, E. 2022. Evaluasi Molecular Docking Senyawa Mangiferin Dari Buah Kasturi (Mangifera Casturi) Sebagai Antikanker Payudara. In Prosiding Seminar Nasional Lingkungan Lahan Basah Vol 7(1)
Komarudin, A. D. P., Purnama, M. F. G., Sari, A. Y., Izzati, A., Sahila, E. N. M. R., Hidayat, S., & Apriliya11, T. N. (2021). Studi In Silico Senyawa Tanaman Nerium oleander terhadap STAT-3 pada Kanker Payudara. Jurnal Farmasi Udayana, 149-155.
Laksmiani, N. P. L., Widiastari, M. I., & Reynaldi, K. R. 2018. The Inhibitory Activity Of Peonidin Purple Sweet Potato In Human Epidermal Receptor-2 Receptor (Her-2) Expression By In Silico Study. In Journal of Physics: Conference Series (Vol. 1040, No. 1, p. 012010). IOP Publishing.
Mardianingrum, R., Bachtiar, K. R., Susanti, S., Nuraisah, A. N. A., & Ruswanto, R. (2021). Studi In Silico Senyawa 1, 4-Naphthalenedione-2-Ethyl-3-Hydroxy sebagai Antiinflamasi dan Antikanker Payudara. Alchemy Jurnal Penelitian Kimia Vol. 17(1): 83-95
Marisa, D., Hayatie, L., Juliati, S., Suhartono, E., & Komari, N. 2021. Molecular Docking Of Phytosterol Compounds From Kelakai (Stenochlaena palustris) as Anti-Breast Cancer. Acta Biochimica Indonesiana Vol. 4(2): 59-59.
Masitha, F. S., & Febriansah, R. (2019). Antioxidant Activity from the Combination of Ethanolic Extract of Tea Leaves (Camellia sinensis) and Soursop Leaves (Annona muricata l.) and Optimation of the Effervescent Granule Production. Mutiara Medika: Jurnal Kedokteran Dan Kesehatan, 19(2), 56-63.
Mohtar, K., Fatimawali, F., Rumondor, E. M., Datu, O. S., & Tallei, T. E. (2021). Studi In Silico Senyawa Eugenol Cengkeh (Syzygium Aromaticum L.) Terhadap Reseptor Er-Α, Er-Β Dan Her-2 Pada Kanker Payudara. Pharmacon Vol. 10(3): 1001-1008.
Mohapatra, S. S., Dash, A. & Jena, M. K., 2018. Receeptors Associated with Pathogenesis of Breast Cancer: A Mini-Review. Journal of emerging Technologies and Innovative Research (JETIR) Vol. 5(11):. 143-153
Mulyati, B. (2019). Peran Genestein Pada Pengikatan Reseptor Estrogen α. Jurnal Industri Elektro dan Penerbangan Vol. 8(2).
Muslimah, N. H., Wijayanti, R. N., Putriarti, D., Lailiyyah, H., & Purnama, E. R. (2022). Prediksi Interaksi Senyawa Aktif Bidara (Ziziphus Mauritiana) Sebagai Antikanker Terhadap Protein Her2. Stigma: Jurnal Matematika Dan Ilmu Pengetahuan Alam Unipa Vol. 15(1): 1-9.
Mylanda, V., Ramadhan, N. E., & Viviani, R. N. 2021. Studi Penambatan Molekuler Senyawa Bioaktif Biji Habbatussauda (Nigella sativa) terhadap ERα sebagai Alternatif Pengobatan Kanker Payudara dalam Upaya Pemberian Data Ilmiah Thibbun Nabawi. Berkala Ilmiah Mahasiswa Farmasi Indonesia (BIMFI) Vol. 8(1): 13-24.
Nitami, S. F., & Febriansah, R. (2019). Penambatan molekular senyawa tangeretin dan kampferol pada protein antiapoptosis Bcl-xL: studi in silico. Acta Pharm Indones, 7(2), 42-50.
Pinanti, H. N., Nafisah, W., Christina, Y. I., Rifa’i, M., & Djati, M. S. 2021. Biflavonoid Compounds From Selaginella Doederleinii Hieron As Anticancer Agents Of Hormone Receptor-Positive (HR+) Breast Cancer Based On In Silico Study. In IOP Conference Series: Earth and Environmental Science (Vol. 743, No. 1, p. 012028). IOP Publishing.
Prasetiawati, R., Permana, B., Soni, D., & Agung, S. N. 2019. Molecular Docking Study Of Xanthone Derivative Compounds Of Mangosteen Rind (Garcinia Mangostana L.) To Er-Α (Estrogen Receptor Alfa) And Er-Β (Estrogen Receptor Beta) As Anti-Breastcancer. Jurnal Ilmiah Farmako Bahari Vol. 10(1): 45-52
Pratama, M. R. F., & Pratomo, G. S. 2017. Pharmacophore optimization of berberine as HER2 inhibitor. Jurnal Farmasi Indonesia Vol. 14(2).
Pratiwi, R. I. A., Rahayu, T., & Mubarakati, N. J. (2020). In Silico Screening of Schleichera oleosa Phytocompounds as Estrogen Receptors Alpha Inhibitors for Breast Cancer. JSMARTech: Journal of Smart Bioprospecting and Technology, 2(1), 014-021.
Rastini, M. B. O., Giantari, N. K. M., Adnyani, K. D. & Laksmiani, N. P. L. 2019. Molecular Docking Aktivitas Antikanker dari Kuersetin terhadap Kanker Payudara secara In Silico. Journal of Chemistry Vol. 13(2): 180-184.
Reynaldi, M. A., & Setiawansyah, A. 2022. Potensi anti-kanker payudara tanaman songga (Strychnos lucida R. Br): Tinjauan interaksi molekuler terhadap reseptor estrogen-α in silico. Sasambo Journal of Pharmacy Vol. 3(1): 30-35.
Rosmalena, R., Prasasty, V. D., Yazid, F., Budianto, E., Elya, B., Lotulung, P., Omar, H., & Hanafi, M. 2021. Isolation, Identification and Synthesis of Neolignans from Phoebe declinata Leaves: Molecular Modeling and Anticancer Evaluation. Systematic Reviews in Pharmacy Vol. 12(1): 1129-1141.
Sethi, A., Joshi, K., Sasikala, K. & Alvala, M., 2019. Molecular Docking in Modern Drug Discovery: Principles and Recent Applications. Drug Discovery and Development-New Advances, pp. 1-21.
Shofi, M. (2021). Studi In Silico Senyawa Kuarsetin Daun Kencana Ungu (Ruellia Tuberosa L.) Sebagai Agen Antikanker Payudara. Jurnal Sintesis: Penelitian Sains, Terapan dan Analisisnya, 2(1), 1-9.
Sianipar, N. F., Hadisaputri, Y. E., Assidqi, K., Salam, S., Yusuf, M., Destiarani, W., Purnamaningsih, R., & So, I. G. 2021. Characterization and Investigation of Stigmasterol Isolated from Rodent Tuber Mutant Plant (Typhonium flagelliforme), Its Molecular Docking as Anticancer on MF-7 Cells. Preprints 2021.
Sozianty, D., & Febriansah, R. 2020. Cytotoxic activity and selectivity index of binahong (Anredera cordifolia) extracts on MCF-7 breast cancer cells and vero normal cells line. Acta Biochimica Indonesiana Vol. 3(2): 72-80.
Suherlan, S., Rohayah & Fakih, T. M., 2021. Uji Aktivitas Antikanker Payudara Senyawa Andrografolida dari Tumbuhan Sambiloto (Andrographis paniculata (Burm F) Ness.) terhadap Human Epidermal Growth Factor Receptor 2 (HER-2) secara In Silico. Jurnal Ilmu Farmasi Farmasyifa Vol. 4(2): 39-50.
Supriyanto, S., Rifa'i, M., Yunianta, Y., & Widjanarko, S. B. 2020. Potential Use of Compounds from Neem Leaves (Azadirachta indica Juss) as PPARg and ERa Inhibitors to Control Breast Cancer Cell Growth In Silico Model. ALCHEMY Vol. 8(1): 18-22.
Syahputra, G., Ambarsari, L., & Sumaryada, T. 2014. Simulasi Docking Kurkumin Enol, Bisdemetoksikurkumin Dan Analognya Sebagai Inhibitor Enzim12-Lipoksigenase. Jurnal Biofisika Vol. 10(1).
The Global Cancer Observatory, 2021. Indonesia. Geneva: World Health Organization.
Yusharyahya, S. N., Bramono, K., Ascobat, P., Hestiantoro, A., Sutanto, N. R., & Fadilah, F. 2019. In silico molecular docking and pharmacophore modelling studies of Trigonella foenum-graceum (fenugreek) interactions with estrogen receptors α and β. Journal of Pharmaceutical Sciences and Research Vol. 11(12): 3705-3711.
Zhou, Z., Qiao, J. X., Shetty, A., Wu, G., Huang, Y., Davidson, N. E., & Wan, Y. 2014. Regulation of estrogen receptor signaling in breast carcinogenesis and breast cancer therapy. Cellular and molecular life sciences: CMLS Vol. 71(8): 1549.
Published
2023-08-28
How to Cite
YUNITA SARI, Alma; FEBRINA, Ellin.
Potensi Senyawa Aktif Tanaman Herbal untuk Pengobatan Kanker Payudara dengan Metode Penambatan Molekuler: Review Artikel.
Jurnal Farmasi Udayana, [S.l.], p. 23-29, aug. 2023.
ISSN 2622-4607.
Available at: <https://ojs.unud.ac.id/index.php/jfu/article/view/86620>. Date accessed: 21 nov. 2024.
doi: https://doi.org/10.24843/JFU.2023.v12.i01.p04.
Section
Articles
