Review : Potensi Aktivitas Anti Virus Dari Produk Alami Lebah Kelulut
Abstract
Up to present, many deadly diseases are caused by viral infections. Herbal therapy is a preventive effort made by the community to overcome diseases that come from viruses. Antiviral drug resistance is also the reason people consume herbs from natural ingredients. One of the natural products has the potential to come from kelulut bee products consisting of propolis, pollen, and honey. The kelulut bee or stingless bee is a type of bee that is commonly found in countries with tropical climates such as Indonesia, but there is still little scientific information that examines its potential as an antiviral. This study aims to analyze data on the potential antiviral activity of kelulut bee products through the collection of related articles. The research conducted is a literature review, so the research method is carried out by collecting related articles using search engines such as NCBI, Sciencedirect, and Google Schoolar. Kelulut bee products such as propolis, pollen and honey have potential pharmacological activity as antiviral. This anti-viral activity is due to the presence of compounds such as alkaloids, flavones, apigenin derivatives and other compounds which will be discussed further. Natural products from kelulut bees have potential as an alternative to antiviral therapy. It is also recommended to conduct more in-depth research on the potential of kelulut bee natural products to obtain these therapeutic products.
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References
1. Francoy TM, Silva RAO, Nunes-Silva P, et al. (2019). Gender identification of five genera of stingless bees (apidae, meliponini) based on wing morphology. Genet. Mol. Res, 8(1): 207-214.
2. Sanjaya V, Astiani D, Sisillia L. (2019). Studi habitat dan sumber pakan lebah kelulut di kawasan cagar alam gunung nyiut di desa pisak kabupaten bengkayang. J Hut. Lestari, 7(2): 786-798.
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5. Yazan LS, Zainal NA, Ali RM, Zali M, Shyfiq MF, Sze OY, Sim TY, Gopalsamy B, Ling VF,Sapuan S, Esa N. (2018). Antiulcer properties of kelulut honey against ethanol-induced gastric ulcer. Pertanika Journal of Science & Technology, 26(1).
6. Dinata,Chandra KDN. (2018). Efektivitas antifungi ekstrak propolis lebah kelulut (trigona spp) terhadap pertumbuhan candida albicans. Proceeding Book of Balidence19 Bali Dental Science and Exhibiton. Diakses dari http://repository. maranatha.edu/27629/1/Perception%20of%20the%20Children%20about%20Their%20Dental%20Health.pdf.
7. Lutpiatina L. (2015). Efektivitas ektrak propolis lebah kelulut (trigona spp) dalam menghambat pertumbuhan salmonella typhi, staphylococcus aureus dan candida albicans. Jurnal Skala Kesehatan, 6(1).
8. Campos JF, dos Santos UP,da Rocha P dos S, and others. (2015). Antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities of propolis from the stingless bee tetragonisca fiebrigi (jataí). Evidence-Based Complementary and Alternative Medicine.
9. Lopes AJO, Vasconcelos CC, Pereira FAN, Silva RHM,et al. (2019). Anti inflammatory and activity and antinociceptive activity of pollen extract collected by stingless bee melipona fasciculata. Int. J. Mol. Sci,20:4512.
10. de Farias JHC, Reis AS,Araύjo MAR, et al. (2014). Effects of stingless bee propolis on experimental asthma. Evidence-Based Complementary and Alternative Medicine.
11. Beale JM, Block JH (Ed.). (2011). Wilson and Gisvold’s textbook of organic medicinal and pharmaceutical chemistry (12th ed). Philadelphia : Lippincott Williams & Wilkins, a Wolters Kluwer business, p. 330-333.
12. Amanda EA, Oktiani BW, Panjaitan FU. (2019). Efektivitas antibakteri ekstrak flavonoid propolis trigona sp (trigona thorasica) terhadap pertumbuhan bakteri porphyromonas gingivalis. Dentin.
13. Khairunnisa B, Rosamah E, Kuspradini H, Kusuma IW, et al. (2020). Uji fitokimia dan antioksidan ekstrak etanol propolis lebah kelulut (tertragonula iridipennis) dari samarinda kalimantan timur. J. Ilm. Manuntung, 6(1):65-69.
14. Khairunnisa K, Mardawati E, Putri SH. (2020). Karakteristik fitokimia dan aktivitas antioksidan ekstrak propolis lebah trigona sp. J. Indust. Pertanian, 02(1):124-129.
15. Gunawan R, Erwin, Syafrizal. (2018). Uji fitokimia dan penentuan aktivitas antioksidan dari madu trigona incisa. Jurnal Atomik, 3(1):18-21.
16. Zahra NN, Muliasari H, Andayani Y, Sudarma IM. (2021). Karakterstik fisikokimia ekstrak madu dan propolis trigona sp. asal lombok utara. J. ARGOTEK UMMAT, 8(1).
17. Kurniawati D, Rironga H, Wulandari D. (2013). Isolasi dan uji aktivitas antimikroba ekstrak etanol propolis trigona spp. J. Prog. Kim, 3(2):74-80.
18. Georgieva K,Popova M, Dimitrova L, Trusheva B, Thanh LN, and Others. (2019). Phytochemical analysis of vietnamese propolis produced by the stingless bee lisotrigona cacciae. PLos ONE J, 14(4):e0216074. doi:10.1371/journal. pone.0216074
19. da Silva IA, da Silva TM, Camara CA, Queiroz N,Magnani M, et al. (2013). Phenolic profile, antioxidant activity and palynological analysis of stingless bee honey from amazons, northern brazil. Food Chem, 14(2013):3552-3558
20. Syafrizal, Hariani N, Budiman. (2016). Analisis fitokimia, toksisitas dan antioksidan ekstrak serbuk sari (bee pollen) lebah trigona spp. Proceeding of Mulawarman Pharmaceutical Diakses dari https://prosiding.farmasi.unmul.ac.id/index.php/mpc/article/view/140
21. de Oliveira RG, Jain S, Freitas LdS, de Araύjo ED. (2019). Phenolic compound, nutritional and antioxidant profile of polllen collected by the genus melipona in north eastern brazil. SciELO Braz. J. Food Technol. https://doi.org/10. 1590/1981-6723.07918
22. Indriyanti A, Andrianne Y. (2020). COVID-19 dan alternatif penggunaan vitamin dan herbal. Pusat Penerbitan Unisba (P2U) LPPM UNISBA.
23. Aldoori AN, Ahmed DS, Kadhom M, Yousif E. (2021). Herbal medicine as an alternative method to treat and prevent COVID-19. Baghdad J Biochem Appl Biol Sci., 2(1):1-20.
24. Yan H, Ma L, Wang H, Wu S, Huang H, Gu Z, Jiang J & Li Y. (2019). Luteolin decreases the yield of influenza a virus in vitro by interfering with the coat protein i complex expression. Journal of Natural Medicines, 73(3):492-494.
25. Ansari WA, Ahmad T, Khan MA, Khan ZA & Khan MF. (2020). Luteolin: a dietary molecule as potential anti covid - 19 agent. Research Square . https://doi.org/10. 21203/rs.3.rs-35368/v1
26. Syamsu RF, Nuryanti S, Arafah, Jamal MF. (2021). Herbal yang berpotensi sebagai antivirus pada covid-19. Molucca Medica. https://doi.org/10.30598/molmed.2021.v14.i1.76
27. Dewi YK, Riyandari BA. (2020). Potensi tanaman lokal sebagai tanaman obat dalam menghambat penyebaran covid-19. Jurnal Pharmascience, 7(2):112-28.
28. Abdullah NA, Zullkiflee N, Zaini SN. (2020). Phytochemicals, mineral contents, antioxidants, and antimicrobial activities of propolis produced by brunei stingless bees geniotrigona thoracica, heterotrigona itama, and tetrigona binghami. Studi J Bio Sci., 27(2020): 2902-2911.
29. Da Silva GR, da Natividade TB, Camara CA, et al. (2014).. Identification of sugar, amino acids and minerals from the pollen of jandaíra stingless bees (melipona subnitida). Food Nutr. Sci., 5:1015–1021.
30. Taibah S. (2019). Uji aktivitas antioksidan ekstrak etanol bee pollen lebah trigona (trigona itama). Journal of Pharmacy and Science, 3(1):21-8.
31. Al- Hatamleh MA, Boer JC, Wilson KL, et al. (2020). Antioxidant-based medicinal properties of stingless bee products: recent progress and future directions. Biomolecules, 10(6): 923.
32. Rahmi H. (2017). Review: Aktivitas antioksidan dari berbagai sumber buah-buahan di indonesia. Indo. J Agro.,2(1).
33. Chan BK, Haron H, Talib RA, Subramaniam P. (2017). Physical properties, antioxidant content and anti-oxidative activities of malaysian stingless kelulut (trigona spp.) honey. J Argicultural Sci., 9(13).
34. Lopes AJO, Vasconcelos CC, Garcia JBS, et al. (2020). Anti-inflammatory and antioxidant activity of pollen extract collected by scaptotrigona affinis postica: in silico, in vitro, and in vivo studies. Antioxidants (Basel), 9(2):103.
35. Yusuf MI. (2019). Peningkatan imunitas non spesifik (innate immunity) mencit balb/c yang diberi ekstrak etanol daun tumbuhan galing (cayratia trifolia l. domin) enhancement of non specific immunity (innate immunity) mice balb/c given ethanol extract of galing plant (cayratia trifolia l. domin). Medical Sains: Jurnal Ilmiah Kefarmasian, 3(2):83-92.
36. Coelho GR, Figueiredo CA, Negri G, et al. (2018). Antiviral activity of geopropolis extract from scaptotrigona aff. postica against rubella virus. J Food Research, 7(6).
2. Sanjaya V, Astiani D, Sisillia L. (2019). Studi habitat dan sumber pakan lebah kelulut di kawasan cagar alam gunung nyiut di desa pisak kabupaten bengkayang. J Hut. Lestari, 7(2): 786-798.
3. Qadariah L, Andrie M, Taurina W. (2019). Uji sifat fisik sediaan salep kombinasi madu kelulut (heterotrigona itama), ekstrak sirih hijau (piper betle l.), dan minyak cengkeh (syzygium aromaticum l.). Jurnal Mahasiswa Farmasi Fakultas Kedokteran Untan, 4(1).
4. Nugroho, Rudy A., and Syafrizal S. (2015). Uji aktivitas antikoagulan ekstrak propolis Trigona laeviceps terhadap darah mencit (Mus musculus L.). Seminar Sains dan Teknologi FMIPA Universitas Mulawarman.
5. Yazan LS, Zainal NA, Ali RM, Zali M, Shyfiq MF, Sze OY, Sim TY, Gopalsamy B, Ling VF,Sapuan S, Esa N. (2018). Antiulcer properties of kelulut honey against ethanol-induced gastric ulcer. Pertanika Journal of Science & Technology, 26(1).
6. Dinata,Chandra KDN. (2018). Efektivitas antifungi ekstrak propolis lebah kelulut (trigona spp) terhadap pertumbuhan candida albicans. Proceeding Book of Balidence19 Bali Dental Science and Exhibiton. Diakses dari http://repository. maranatha.edu/27629/1/Perception%20of%20the%20Children%20about%20Their%20Dental%20Health.pdf.
7. Lutpiatina L. (2015). Efektivitas ektrak propolis lebah kelulut (trigona spp) dalam menghambat pertumbuhan salmonella typhi, staphylococcus aureus dan candida albicans. Jurnal Skala Kesehatan, 6(1).
8. Campos JF, dos Santos UP,da Rocha P dos S, and others. (2015). Antimicrobial, antioxidant, anti-inflammatory, and cytotoxic activities of propolis from the stingless bee tetragonisca fiebrigi (jataí). Evidence-Based Complementary and Alternative Medicine.
9. Lopes AJO, Vasconcelos CC, Pereira FAN, Silva RHM,et al. (2019). Anti inflammatory and activity and antinociceptive activity of pollen extract collected by stingless bee melipona fasciculata. Int. J. Mol. Sci,20:4512.
10. de Farias JHC, Reis AS,Araύjo MAR, et al. (2014). Effects of stingless bee propolis on experimental asthma. Evidence-Based Complementary and Alternative Medicine.
11. Beale JM, Block JH (Ed.). (2011). Wilson and Gisvold’s textbook of organic medicinal and pharmaceutical chemistry (12th ed). Philadelphia : Lippincott Williams & Wilkins, a Wolters Kluwer business, p. 330-333.
12. Amanda EA, Oktiani BW, Panjaitan FU. (2019). Efektivitas antibakteri ekstrak flavonoid propolis trigona sp (trigona thorasica) terhadap pertumbuhan bakteri porphyromonas gingivalis. Dentin.
13. Khairunnisa B, Rosamah E, Kuspradini H, Kusuma IW, et al. (2020). Uji fitokimia dan antioksidan ekstrak etanol propolis lebah kelulut (tertragonula iridipennis) dari samarinda kalimantan timur. J. Ilm. Manuntung, 6(1):65-69.
14. Khairunnisa K, Mardawati E, Putri SH. (2020). Karakteristik fitokimia dan aktivitas antioksidan ekstrak propolis lebah trigona sp. J. Indust. Pertanian, 02(1):124-129.
15. Gunawan R, Erwin, Syafrizal. (2018). Uji fitokimia dan penentuan aktivitas antioksidan dari madu trigona incisa. Jurnal Atomik, 3(1):18-21.
16. Zahra NN, Muliasari H, Andayani Y, Sudarma IM. (2021). Karakterstik fisikokimia ekstrak madu dan propolis trigona sp. asal lombok utara. J. ARGOTEK UMMAT, 8(1).
17. Kurniawati D, Rironga H, Wulandari D. (2013). Isolasi dan uji aktivitas antimikroba ekstrak etanol propolis trigona spp. J. Prog. Kim, 3(2):74-80.
18. Georgieva K,Popova M, Dimitrova L, Trusheva B, Thanh LN, and Others. (2019). Phytochemical analysis of vietnamese propolis produced by the stingless bee lisotrigona cacciae. PLos ONE J, 14(4):e0216074. doi:10.1371/journal. pone.0216074
19. da Silva IA, da Silva TM, Camara CA, Queiroz N,Magnani M, et al. (2013). Phenolic profile, antioxidant activity and palynological analysis of stingless bee honey from amazons, northern brazil. Food Chem, 14(2013):3552-3558
20. Syafrizal, Hariani N, Budiman. (2016). Analisis fitokimia, toksisitas dan antioksidan ekstrak serbuk sari (bee pollen) lebah trigona spp. Proceeding of Mulawarman Pharmaceutical Diakses dari https://prosiding.farmasi.unmul.ac.id/index.php/mpc/article/view/140
21. de Oliveira RG, Jain S, Freitas LdS, de Araύjo ED. (2019). Phenolic compound, nutritional and antioxidant profile of polllen collected by the genus melipona in north eastern brazil. SciELO Braz. J. Food Technol. https://doi.org/10. 1590/1981-6723.07918
22. Indriyanti A, Andrianne Y. (2020). COVID-19 dan alternatif penggunaan vitamin dan herbal. Pusat Penerbitan Unisba (P2U) LPPM UNISBA.
23. Aldoori AN, Ahmed DS, Kadhom M, Yousif E. (2021). Herbal medicine as an alternative method to treat and prevent COVID-19. Baghdad J Biochem Appl Biol Sci., 2(1):1-20.
24. Yan H, Ma L, Wang H, Wu S, Huang H, Gu Z, Jiang J & Li Y. (2019). Luteolin decreases the yield of influenza a virus in vitro by interfering with the coat protein i complex expression. Journal of Natural Medicines, 73(3):492-494.
25. Ansari WA, Ahmad T, Khan MA, Khan ZA & Khan MF. (2020). Luteolin: a dietary molecule as potential anti covid - 19 agent. Research Square . https://doi.org/10. 21203/rs.3.rs-35368/v1
26. Syamsu RF, Nuryanti S, Arafah, Jamal MF. (2021). Herbal yang berpotensi sebagai antivirus pada covid-19. Molucca Medica. https://doi.org/10.30598/molmed.2021.v14.i1.76
27. Dewi YK, Riyandari BA. (2020). Potensi tanaman lokal sebagai tanaman obat dalam menghambat penyebaran covid-19. Jurnal Pharmascience, 7(2):112-28.
28. Abdullah NA, Zullkiflee N, Zaini SN. (2020). Phytochemicals, mineral contents, antioxidants, and antimicrobial activities of propolis produced by brunei stingless bees geniotrigona thoracica, heterotrigona itama, and tetrigona binghami. Studi J Bio Sci., 27(2020): 2902-2911.
29. Da Silva GR, da Natividade TB, Camara CA, et al. (2014).. Identification of sugar, amino acids and minerals from the pollen of jandaíra stingless bees (melipona subnitida). Food Nutr. Sci., 5:1015–1021.
30. Taibah S. (2019). Uji aktivitas antioksidan ekstrak etanol bee pollen lebah trigona (trigona itama). Journal of Pharmacy and Science, 3(1):21-8.
31. Al- Hatamleh MA, Boer JC, Wilson KL, et al. (2020). Antioxidant-based medicinal properties of stingless bee products: recent progress and future directions. Biomolecules, 10(6): 923.
32. Rahmi H. (2017). Review: Aktivitas antioksidan dari berbagai sumber buah-buahan di indonesia. Indo. J Agro.,2(1).
33. Chan BK, Haron H, Talib RA, Subramaniam P. (2017). Physical properties, antioxidant content and anti-oxidative activities of malaysian stingless kelulut (trigona spp.) honey. J Argicultural Sci., 9(13).
34. Lopes AJO, Vasconcelos CC, Garcia JBS, et al. (2020). Anti-inflammatory and antioxidant activity of pollen extract collected by scaptotrigona affinis postica: in silico, in vitro, and in vivo studies. Antioxidants (Basel), 9(2):103.
35. Yusuf MI. (2019). Peningkatan imunitas non spesifik (innate immunity) mencit balb/c yang diberi ekstrak etanol daun tumbuhan galing (cayratia trifolia l. domin) enhancement of non specific immunity (innate immunity) mice balb/c given ethanol extract of galing plant (cayratia trifolia l. domin). Medical Sains: Jurnal Ilmiah Kefarmasian, 3(2):83-92.
36. Coelho GR, Figueiredo CA, Negri G, et al. (2018). Antiviral activity of geopropolis extract from scaptotrigona aff. postica against rubella virus. J Food Research, 7(6).
Published
2021-12-31
How to Cite
BATISTUTA, Muhammad Alib; AULIA, Annisa; KUSTIAWAN, Paula Mariana.
Review : Potensi Aktivitas Anti Virus Dari Produk Alami Lebah Kelulut.
Jurnal Farmasi Udayana, [S.l.], p. 144-148, dec. 2021.
ISSN 2622-4607.
Available at: <https://ojs.unud.ac.id/index.php/jfu/article/view/74983>. Date accessed: 24 apr. 2024.
doi: https://doi.org/10.24843/JFU.2021.v10.i02.p06.
Section
Articles
