Literature Review: Faktor yang Mempengaruhi Ketaatan Pengobatan pada Pasien Malaria
Abstract
Efektivitas pengobatan malaria sangat tergantung pada ketaatan pasien terhadap regimen pengobatan yang diberikan oleh dokter. Dengan mengidentifikasi dan memahami faktor-faktor yang mempengaruhi akan mempermudah pemilihan strategi untuk mengatasi permasalahan tersebut. Penulisan artikel ini bertujuan untuk mengidentifikasi faktor-faktor yang mempengaruhi ketaatan pengobatan pada pasien malaria. Penelusuran artikel berdasarkan kata kunci dan diskrining dengan kriteria inklusi dan eksklusi. Kemudian dilakukan analisis data demografi, jenis obat, isi penelitian dan mencari faktor utama yang mempengaruhi ketaatan dengan menganalisis faktor yang paling banyak ditemukan pada artikel yang di review. Dari 104 artikel, ditemukan 12 artikel memenuhi kriteria inklusi dan eksklusi. Hasil penelusuran 12 artikel ditemukan faktor utama yang mempengaruhi ketaatan pengobatan adalah persepsi merasa sehat sebelum obat habis. Adapun faktor lain yang juga ditemukan adalah status ekonomi, pekerjaan, usia, bahasa, tingkat pendidikan, kualitas pelayanan kesehatan, ketersediaan stok obat, metode edukasi pengobatan, keluhan muntah, jenis obat antimalaria, karakteristik obat antimalaria, durasi pengobatan, persepsi hambatan, perceived susceptibility, persepsi obat-obatan, persepsi diagnosis, kebiasaan menyimpan obat, dukungan keluarga, pendamping minum obat, lupa, dan pengetahuan pengobatan malaria. Dari literature review ini dapat disimpulkan bahwa faktor utama yang mempengaruhi ketaatan adalah persepsi merasa sehat sebelum obat habis.
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References
Amponsah, A. O., Vosper, H., & Marfo, A. F. A. (2015). Patient Related Factors Affecting Adherence to Antimalarial Medication in an Urban Estate in Ghana. Malaria Research and Treatment, 2015. https://doi.org/10.1155/2015/452539
Banek, K., Lalani, M., Staedke, S. G., & Chandramohan, D. (2014). Adherence to Artemisinin-Based Combination Therapy for the Treatment of Malaria: A Systematic Review of the Evidence. In Malaria Journal (Vol. 13). http://www.malariajournal.com/content/13/1/7
Bawate, C., Callender-Carter, S. T., Guyah, B., & Ouma, C. (2024). Factors Influencing Patients’ Adherence to Malaria Artemisinin-Based Combination Therapy in Kamuli District, Uganda. Malaria Journal, 23(1), 1. https://doi.org/10.1186/s12936-023-04824-8
Beer, N., Ali, A. S., Rotllant, G., Abass, A. K., Omari, R. S., Al-Mafazy, A. W. H., Björkman, A., & Källander, K. (2009). Adherence to Artesunate Amodiaquine Combination Therapy for Uncomplicated Malaria in Children in Zanzibar, Tanzania. Tropical Medicine and International Health, 14(7), 766–774. https://doi.org/10.1111/j.1365-3156.2009.02289.x
Berwulo, J., Kusumaningsih, I., & Adyatmaka, A. (2020). Efektivitas Telenursing Terhadap Kepatuhan Minum Obat pada Pasien Malaria di Puskesmas Wilayah Kerja Dinas Kesehatan Kabupaten Mimika. Jurnal Kesehatan, 7(2), 48–60. https://doi.org/10.35913/jk.v7i2.159
Bulafu, D., Tamale, B. N., Ninsiima, L. R., Baguma, J. N., Namakula, L. N., Niyongabo, F., Lubega, G. B., Aruhomukama, D., Ndejjo, R., & Musoke, D. (2023). Adherence to Malaria Treatment Guidelines Among Health Care Workers in Private Health Facilities in Kampala’s Informal Settlements, Uganda. PLOS Global Public Health, 3(9). https://doi.org/10.1371/journal.pgph.0002220
Depoortere, E., Guthmann, J. P., Sipilanyambe, N., Nkandu, E., Fermon, F., Balkan, S., & Legros, D. (2004). Adherence to The Combination of Sulphadoxine-Pyrimethamine and Artesunate in the Maheba Refugee Settlement, Zambia. Tropical Medicine and International Health, 9(1), 62–67. https://doi.org/10.1046/j.1365-3156.2003.01157.x
Diliani, D., Budiman, B., Safarina, L., Nurharlinah, N., & Suharjiman, S. (2023). Rancangan Sistem Informasi Kepatuhan Minum Obat Malaria Dalam Menunjang Penerapan Sistem Kepatuhan Minum Obat pada Pasien Malaria Tertiana. Journal of Telenursing, 5(2), 2329–2337. https://doi.org/10.31539/joting.v5i2.5328
Farouk, A. H. (2016). Analisis Faktor yang Berhubungan dengan Kepatuhan Pengobatan Malaria Di Kabupaten Sarolangun Provinsi Jambi Tahun 2015. Jurnal Ilmiah Universitas Batanghari Jambi, 16, 1–11. https://doi.org/http://dx.doi.org/10.33087/jiubj.v16i1.73
Gerstl, S., Dunkley, S., Mukhtar, A., Baker, S., & Maikere, J. (2010). Successful Introduction of Artesunate Combination Therapy is Not Enough to Fight Malaria: Results From an Adherence Study in Sierra Leone. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(5), 328–335. https://doi.org/10.1016/j.trstmh.2009.12.008
Health Organization, W. (2023). WHO Guidelines for Malaria. https://www.mmv.org/sites/ default/files/content/document/WHO-UCN-GMP-2023.01-eng.pdf
Hossain, M. S., Matin, M. A., Ferdous, N.-E. N., Hasan, A., Sazed, S. A., Neogi, A. K., Chakma, S., Islam, M. A., Khan, A. A., Haque, M. E., Islam, S., Islam, M. N., Khan, W. A., Islam, M. A., Haque, R., & Alam, M. S. (2023). Adherence to Anti-Malarial Treatment in Malaria Endemic Areas of Bangladesh. Pathogens (Basel, Switzerland), 12(12). https://doi.org/10.3390/pathogens12121392
Kalyango, J. N., Rutebemberwa, E., Karamagi, C., Mworozi, E., Ssali, S., Alfven, T., & Peterson, S. (2013). High Adherence to Antimalarials and Antibiotics under Integrated Community Case Management of Illness in Children Less than Five Years in Eastern Uganda. PLoS ONE, 8(3). https://doi.org/10.1371/journal.pone.0060481
Kementerian Kesehatan RI. (2020). Buku Saku Tatalaksana Kasus Malaria. Kementerian Kesehatan RI.
Kementerian Kesehatan RI. (2024). Laporan Kinerja Direktorat P2PM Tahun 2023. https://p2p.kemkes.go.id/wpcontent/uploads/2024/02/%20Lapkin2023P2PM_16022024.pdf
Kusa, S., & Jelatu, V. A. (2021). Gambaran Pengetahuan Minum Obat Pasien Malaria Falciparum di Puskesmas Sentani Kabupaten Jayapura [Stikes Jayapura]. https://repository.stikesjypr.ac.id/id/eprint/8/
Lawford, H., Zurovac, D., O’Reilly, L., Hoibak, S., Cowley, A., Munga, S., Vulule, J., Juma, E., Snow, R. W., & Allan, R. (2011). Adherence to Prescribed Artemisinin-Based Combination Therapy in Garissa and Bunyala districts, Kenya. Malaria Journal, 10(1), 281. https://doi.org/10.1186/1475-2875-10-281
Lemma, H., Löfgren, C., & San Sebastian, M. (2011). Adherence to A Six-Dose Regimen of Artemether-Lumefantrine Among Uncomplicated Plasmodium Falciparum Patients in the Tigray Region, Ethiopia. Malaria Journal, 10. https://doi.org/10.1186/1475-2875-10-349
Mace, K. E., Mwandama, D., Jafali, J., Luka, M., Filler, S. J., Sande, J., Ali, D., Kachur, S. P., Mathanga, D. P., & Skarbinski, J. (2011). Adherence to Treatment with Artemether-Lumefantrine for Uncomplicated Malaria in Rural Malawi. Clinical Infectious Diseases, 53(8), 772–779. https://doi.org/10.1093/cid/cir498
Ogolla, J. O., Ayaya, S. O., & Otieno, C. A. (2013). Levels of Adherence to Coartem© In the Routine Treatment of Uncomplicated Malaria in Children Aged Below Five Years, in Kenya. In Iranian J Publ Health (Vol. 42, Issue 2). http://ijph.tums.ac.ir
Pratiwi, V. D., Hendra, P., & Virginia, D. M. (2024). Ketaatan Terapi Antihipertensi dengan Terkontrolnya Tekanan Darah pada Pasien Hipertensi Komorbid DM Tipe2 di Puskesmas Kabupaten Sleman. Jurnal Manajemen Kesehatan Yayasan Dr. Soetomo, 10(1).
Rahmalia, A., Poespoprodjo, J. R., Landuwulang, C. U. R., Ronse, M., Kenangalem, E., Burdam, F. H., Thriemer, K., Devine, A., Price, R. N., Peeters Grietens, K., Ley, B., & Gryseels, C. (2023). Adherence to 14-Day Radical Cure for Plasmodium Vivax Malaria in Papua, Indonesia: A Mixed-Methods Study. Malaria Journal, 22(1). https://doi.org/10.1186/s12936-023-04578-3
Shafira, I. D., & Krisanti, I. G. (2020). Faktor-Faktor Kepatuhan Minum Obat pada Penderita Malaria Vivax di Puskesmas Hanura Kabupaten Pesawaran. Jurnal Analis Kesehatan, 8(2), 53. https://doi.org/10.26630/jak.v8i2.1863
Snyder, H. (2019). Literature Review as a Research Methodology: an Overview and Guidelines. Journal of Business Research, 104, 333–339. https://doi.org/10.1016/j.jbusres.2019.07.039
Suharmanto. (2024). Persepsi Kerentanan Berhubungan Dengan Perilaku Patuh Terhadap Pengobatan Malaria. Jurnal Ilmiah STIKES Kendal, 14(3), 983–988. http://journal.stikeskendal.ac.id/index.php/PSKM
Weni, A. D. D., Fitriah, Nenu, M. B. S., Tory, M. V., Andajani, S., & Basuki, S. (2019). Pengaruh Faktor Pendidikan Terhadap Akses dan Kepatuhan Pengobatan Malaria Di Kabupaten Sikka Tahun 2018. Jurnal Keperawatan Muhammadiyah, 139–144.
Wuryanto, M. A. (2008). Tingkat Kepatuhan Penderita Malaria Vivax Dalam Minum Obat Serta Faktor yang Mempengaruhinya Studi Pada Penderita Malaria Vivax Di Kabupaten Banjarnegara Tahun 2005. Jurnal Promosi Kesehatan Indonesia, 3(1), 24–30.
Yakasai, A. M., Hamza, M., Dalhat, M. M., Bello, M., Gadanya, M. A., Yaqub, Z. M., Ibrahim, D. A., & Hassan-Hanga, F. (2015). Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis. In Journal of Tropical Medicine (Vol. 2015). Hindawi Publishing Corporation. https://doi.org/10.1155/2015/189232
Banek, K., Lalani, M., Staedke, S. G., & Chandramohan, D. (2014). Adherence to Artemisinin-Based Combination Therapy for the Treatment of Malaria: A Systematic Review of the Evidence. In Malaria Journal (Vol. 13). http://www.malariajournal.com/content/13/1/7
Bawate, C., Callender-Carter, S. T., Guyah, B., & Ouma, C. (2024). Factors Influencing Patients’ Adherence to Malaria Artemisinin-Based Combination Therapy in Kamuli District, Uganda. Malaria Journal, 23(1), 1. https://doi.org/10.1186/s12936-023-04824-8
Beer, N., Ali, A. S., Rotllant, G., Abass, A. K., Omari, R. S., Al-Mafazy, A. W. H., Björkman, A., & Källander, K. (2009). Adherence to Artesunate Amodiaquine Combination Therapy for Uncomplicated Malaria in Children in Zanzibar, Tanzania. Tropical Medicine and International Health, 14(7), 766–774. https://doi.org/10.1111/j.1365-3156.2009.02289.x
Berwulo, J., Kusumaningsih, I., & Adyatmaka, A. (2020). Efektivitas Telenursing Terhadap Kepatuhan Minum Obat pada Pasien Malaria di Puskesmas Wilayah Kerja Dinas Kesehatan Kabupaten Mimika. Jurnal Kesehatan, 7(2), 48–60. https://doi.org/10.35913/jk.v7i2.159
Bulafu, D., Tamale, B. N., Ninsiima, L. R., Baguma, J. N., Namakula, L. N., Niyongabo, F., Lubega, G. B., Aruhomukama, D., Ndejjo, R., & Musoke, D. (2023). Adherence to Malaria Treatment Guidelines Among Health Care Workers in Private Health Facilities in Kampala’s Informal Settlements, Uganda. PLOS Global Public Health, 3(9). https://doi.org/10.1371/journal.pgph.0002220
Depoortere, E., Guthmann, J. P., Sipilanyambe, N., Nkandu, E., Fermon, F., Balkan, S., & Legros, D. (2004). Adherence to The Combination of Sulphadoxine-Pyrimethamine and Artesunate in the Maheba Refugee Settlement, Zambia. Tropical Medicine and International Health, 9(1), 62–67. https://doi.org/10.1046/j.1365-3156.2003.01157.x
Diliani, D., Budiman, B., Safarina, L., Nurharlinah, N., & Suharjiman, S. (2023). Rancangan Sistem Informasi Kepatuhan Minum Obat Malaria Dalam Menunjang Penerapan Sistem Kepatuhan Minum Obat pada Pasien Malaria Tertiana. Journal of Telenursing, 5(2), 2329–2337. https://doi.org/10.31539/joting.v5i2.5328
Farouk, A. H. (2016). Analisis Faktor yang Berhubungan dengan Kepatuhan Pengobatan Malaria Di Kabupaten Sarolangun Provinsi Jambi Tahun 2015. Jurnal Ilmiah Universitas Batanghari Jambi, 16, 1–11. https://doi.org/http://dx.doi.org/10.33087/jiubj.v16i1.73
Gerstl, S., Dunkley, S., Mukhtar, A., Baker, S., & Maikere, J. (2010). Successful Introduction of Artesunate Combination Therapy is Not Enough to Fight Malaria: Results From an Adherence Study in Sierra Leone. Transactions of the Royal Society of Tropical Medicine and Hygiene, 104(5), 328–335. https://doi.org/10.1016/j.trstmh.2009.12.008
Health Organization, W. (2023). WHO Guidelines for Malaria. https://www.mmv.org/sites/ default/files/content/document/WHO-UCN-GMP-2023.01-eng.pdf
Hossain, M. S., Matin, M. A., Ferdous, N.-E. N., Hasan, A., Sazed, S. A., Neogi, A. K., Chakma, S., Islam, M. A., Khan, A. A., Haque, M. E., Islam, S., Islam, M. N., Khan, W. A., Islam, M. A., Haque, R., & Alam, M. S. (2023). Adherence to Anti-Malarial Treatment in Malaria Endemic Areas of Bangladesh. Pathogens (Basel, Switzerland), 12(12). https://doi.org/10.3390/pathogens12121392
Kalyango, J. N., Rutebemberwa, E., Karamagi, C., Mworozi, E., Ssali, S., Alfven, T., & Peterson, S. (2013). High Adherence to Antimalarials and Antibiotics under Integrated Community Case Management of Illness in Children Less than Five Years in Eastern Uganda. PLoS ONE, 8(3). https://doi.org/10.1371/journal.pone.0060481
Kementerian Kesehatan RI. (2020). Buku Saku Tatalaksana Kasus Malaria. Kementerian Kesehatan RI.
Kementerian Kesehatan RI. (2024). Laporan Kinerja Direktorat P2PM Tahun 2023. https://p2p.kemkes.go.id/wpcontent/uploads/2024/02/%20Lapkin2023P2PM_16022024.pdf
Kusa, S., & Jelatu, V. A. (2021). Gambaran Pengetahuan Minum Obat Pasien Malaria Falciparum di Puskesmas Sentani Kabupaten Jayapura [Stikes Jayapura]. https://repository.stikesjypr.ac.id/id/eprint/8/
Lawford, H., Zurovac, D., O’Reilly, L., Hoibak, S., Cowley, A., Munga, S., Vulule, J., Juma, E., Snow, R. W., & Allan, R. (2011). Adherence to Prescribed Artemisinin-Based Combination Therapy in Garissa and Bunyala districts, Kenya. Malaria Journal, 10(1), 281. https://doi.org/10.1186/1475-2875-10-281
Lemma, H., Löfgren, C., & San Sebastian, M. (2011). Adherence to A Six-Dose Regimen of Artemether-Lumefantrine Among Uncomplicated Plasmodium Falciparum Patients in the Tigray Region, Ethiopia. Malaria Journal, 10. https://doi.org/10.1186/1475-2875-10-349
Mace, K. E., Mwandama, D., Jafali, J., Luka, M., Filler, S. J., Sande, J., Ali, D., Kachur, S. P., Mathanga, D. P., & Skarbinski, J. (2011). Adherence to Treatment with Artemether-Lumefantrine for Uncomplicated Malaria in Rural Malawi. Clinical Infectious Diseases, 53(8), 772–779. https://doi.org/10.1093/cid/cir498
Ogolla, J. O., Ayaya, S. O., & Otieno, C. A. (2013). Levels of Adherence to Coartem© In the Routine Treatment of Uncomplicated Malaria in Children Aged Below Five Years, in Kenya. In Iranian J Publ Health (Vol. 42, Issue 2). http://ijph.tums.ac.ir
Pratiwi, V. D., Hendra, P., & Virginia, D. M. (2024). Ketaatan Terapi Antihipertensi dengan Terkontrolnya Tekanan Darah pada Pasien Hipertensi Komorbid DM Tipe2 di Puskesmas Kabupaten Sleman. Jurnal Manajemen Kesehatan Yayasan Dr. Soetomo, 10(1).
Rahmalia, A., Poespoprodjo, J. R., Landuwulang, C. U. R., Ronse, M., Kenangalem, E., Burdam, F. H., Thriemer, K., Devine, A., Price, R. N., Peeters Grietens, K., Ley, B., & Gryseels, C. (2023). Adherence to 14-Day Radical Cure for Plasmodium Vivax Malaria in Papua, Indonesia: A Mixed-Methods Study. Malaria Journal, 22(1). https://doi.org/10.1186/s12936-023-04578-3
Shafira, I. D., & Krisanti, I. G. (2020). Faktor-Faktor Kepatuhan Minum Obat pada Penderita Malaria Vivax di Puskesmas Hanura Kabupaten Pesawaran. Jurnal Analis Kesehatan, 8(2), 53. https://doi.org/10.26630/jak.v8i2.1863
Snyder, H. (2019). Literature Review as a Research Methodology: an Overview and Guidelines. Journal of Business Research, 104, 333–339. https://doi.org/10.1016/j.jbusres.2019.07.039
Suharmanto. (2024). Persepsi Kerentanan Berhubungan Dengan Perilaku Patuh Terhadap Pengobatan Malaria. Jurnal Ilmiah STIKES Kendal, 14(3), 983–988. http://journal.stikeskendal.ac.id/index.php/PSKM
Weni, A. D. D., Fitriah, Nenu, M. B. S., Tory, M. V., Andajani, S., & Basuki, S. (2019). Pengaruh Faktor Pendidikan Terhadap Akses dan Kepatuhan Pengobatan Malaria Di Kabupaten Sikka Tahun 2018. Jurnal Keperawatan Muhammadiyah, 139–144.
Wuryanto, M. A. (2008). Tingkat Kepatuhan Penderita Malaria Vivax Dalam Minum Obat Serta Faktor yang Mempengaruhinya Studi Pada Penderita Malaria Vivax Di Kabupaten Banjarnegara Tahun 2005. Jurnal Promosi Kesehatan Indonesia, 3(1), 24–30.
Yakasai, A. M., Hamza, M., Dalhat, M. M., Bello, M., Gadanya, M. A., Yaqub, Z. M., Ibrahim, D. A., & Hassan-Hanga, F. (2015). Adherence to Artemisinin-Based Combination Therapy for the Treatment of Uncomplicated Malaria: A Systematic Review and Meta-Analysis. In Journal of Tropical Medicine (Vol. 2015). Hindawi Publishing Corporation. https://doi.org/10.1155/2015/189232
Published
2025-01-10
How to Cite
MERI, Meri; HARTAYU, Titien Siwi.
Literature Review: Faktor yang Mempengaruhi Ketaatan Pengobatan pada Pasien Malaria.
Jurnal Farmasi Udayana, [S.l.], p. 37-45, jan. 2025.
ISSN 2622-4607.
Available at: <https://ojs.unud.ac.id/index.php/jfu/article/view/118295>. Date accessed: 10 jan. 2025.
doi: https://doi.org/10.24843/JFU.2024.v13.i02.p01.
Section
Articles
