Hubungan Kepatuhan Terapi Antihiperglikemia Terhadap Terkontrolnya HbA1c pada Pasien Terdiagnosa Diabetes Melitus Tipe 2 di RSU Prima Medika, Denpasar
Abstract
Diabetes mellitus is a disease caused by chronic metabolic disorders accompanied by increased blood glucose levels. Adherence to treatment is very important to achieve therapeutic success in type 2 diabetes mellitus (T2DM) patients and prevent complications. HbA1c value is one of the parameters used to see the success of T2DM therapy. This study was conducted to determine the relationship between compliance with antihyperglycemic therapy for T2DM patients and the patient's HbA1c value. This study used a cross-sectional research design and data collection was carried out by non-random sampling with purposive sampling technique. The research subjects were 100 T2DM patients at RSU Prima Medika Denpasar, Bali with the age of 40-70 years. The level of patient compliance in taking medication was measured by the Medication Possession Ratio (MPR) method based on patient treatment records. The results showed 78% aged 40-59 years, 53% female, 86% T2DM with comorbidities 62% received combination therapy, 87% were compliant with taking medication. There was no significant relationship between the characteristics of T2DM patients and compliance (p-value > 0.05). There was a significant association between medication adherence and controlled HbA1c values in patients with T2DM (p-value < 0.05; OR (95%CI) : 4,902 (1,026 - 23,430)).
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References
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American Diabetes Association. (2018). Standards of medical care in diabetes-2018 A bridged for primary care providers. Clinical Diabetes, 36(1), 14–37. https://doi.org/10.2337/cd17-0119
Anggraini, R., Nadatein, I., & Astuti, P. (2020). Relationship of HbA1c with fasting blood glucose on diagnostic values and lifestyle in type ii diabetes mellitus patients. Medicra (Journal of Medical Laboratory Science/Technology), 3(1), 5–11. https://doi.org/10.21070/medicra.v3i1.651
Kementerian Kesehatan Republik Indonesia. (2019). Laporan Nasional RISKESDAS 2018.
PERKENI. (2021). Pedoman pengelolaan dan pencegahan diabetes melitus tipe 2 dewasa di Indonesia-2021.
Fatiha, C. N., & Sabiti, F. B. (2021). Peningkatan kepatuhan minum obat melalui konseling apoteker pada pasien diabetes mellitus tipe 2 di Puskesmas Halmahera Kota Semarang. JPSCR: Journal of Pharmaceutical Science and Clinical Research, 6(1), 41-48. https://doi.org/10.20961/jpscr.v6i1.39297
Firdiawan, A., Andayani, T. M., & Kristina, S. A. (2021). Hubungan kepatuhan pengobatan terhadap outcome klinik pasien diabetes melitus tipe 2 dengan Medication Adherence Rating Scale-5 (MARS-5). Majalah Farmaseutik, 17(1), 22-28. https://doi.org/10.22146/farmaseutik.v17i1.48053
Fitriyani, F., Andrajati, R., & Trisna, Y. (2021). Analisis efektivitas-biaya terapi kombinasi metformin-insulin dan metformin-sulfonilurea pada pasien rawat jalan dengan diabetes melitus tipe 2 di RSUPN Dr. Cipto Mangunkusumo. Indonesian Journal of Clinical Pharmacy, 10(1), 10-21. https://doi.org/10.15416/ijcp.2021.10.1.10
Galicia-Garcia, U., Benito-Vicente, A., Jebari, S., Larrea-Sebal, A., Siddiqi, H., Uribe, K. B., Ostolaza, H., & Martín, C. (2020). Pathophysiology of type 2 diabetes mellitus. In International Journal of Molecular Sciences, 21 (17), 1–34. https://doi.org/10.3390/ijms21176275
García-Pérez, L. E., Álvarez, M., Dilla, T., Gil-Guillén, V., & Orozco-Beltrán, D. (2013). Adherence to therapies in patients with type 2 diabetes. Diabetes Therapy, 4 (2), 175–194. Springer Healthcare. https://doi.org/10.1007/s13300-013-0034-y
Hendra, P., Setiawan, C. H., Virginia, D. M., & Julianus, J. (2022). Keberhasilan terapi pada pasien risiko kardiovaskular (Z. D. Pramono, Ed.). Sanata Dharma University Press.
Horvat, O., Popržen, J., Tomas, A., Paut Kusturica, M., Tomić, Z., & Sabo, A. (2018). Factors associated with non-adherence among type 2 diabetic patients in primary care setting in eastern Bosnia and Herzegovina. Primary Care Diabetes, 12(2), 147–154. https://doi.org/https://doi.org/10.1016/j.pcd.2017.10.002
Leander, D. J., & Tahapary, D. L. (2020). Pemilihan obat antidiabetik oral pada pasien diabetes melitus tipe 2 dengan risiko tinggi untuk kejadian kardiovaskular. Jurnal Penyakit Dalam Indonesia, 7 (4), 240-248.
Lee, C. S., Tan, J. H. M., Sankari, U., Koh, Y. L. E., & Tan, N. C. (2017). Assessing oral medication adherence among patients with type 2 diabetes mellitus treated with polytherapy in a developed Asian community: A cross-sectional study. BMJ Open, 7:e016317. https://doi.org/10.1136/bmjopen-2017-016317
Maulidya, N., & Oktianti, D. (2021). Pola penggunaan obat antidiabetes di Puskesmas Grabag Magelang. Journal of Holistics and Health Sciences, 3(1) https://doi.org/10.35473/jhhs.v3i1.71.
Milita, F., Handayani, S., Setiaji, B. (2021). Kejadian diabetes mellitus tipe II pada lanjut usia di Indonesia (Analisis Riskesdas 2018). Jurnal Kedokteran dan Kesehatan, 17(1), 9-20 https://jurnal.umj.ac.id/index.php/JKK
Prasetyo, A. (2019). Tatalaksana diabetes melitus pada pasien geriatri. Cermin Dunia Kedokteran, 46(6), 420-422. https://doi.org/10.55175/cdk.v46i6.435
Reyaldi, C. B., -, A., & Candradewi, S. F. (2021). Evaluasi kadar gula darah pasien berdasarkan kajian usia dan komplikasi penyakit pada pasien diabetes mellitus tipe-2 di Puskesmas Jetis 1 Bantul periode September–November 2019. Jurnal Farmasi Udayana, 10(2),131-137. https://doi.org/10.24843/jfu.2021.v10.i02.p04
Saeedi, P., Petersohn, I., Salpea, P., Malanda, B., Karuranga, S., Unwin, N., Colagiuri, S., Guariguata, L., Motala, A. A., Ogurtsova, K., Shaw, J. E., Bright, D., & Williams, R. (2019). Global and regional diabetes prevalence estimates for 2019 and projections for 2030 and 2045: Results from the International Diabetes Federation Diabetes Atlas, 9th edition. Diabetes Research and Clinical Practice, 157, 107843. https://doi.org/10.1016/j.diabres.2019.107843
Jasmine, S. N., Wahyuningsih, S., Thadeus, S. M. (2020). Analisis faktor tingkat kepatuhan minum obat pasien diabetes melitus di Puskesmas Pancoran Mas periode Maret-April 2019. Jurnal Manajemen Kesehatan Indonesia, 8(1), 61-66.
Utomo, M. R. S., Wungouw, H., & Marunduh, S. (2015). Kadar HbA1c pada pasien diabetes melitus tipe 2 di Puskesmas Bahu Kecamatan Malalayang Kota Manado. Jurnal e-Biomedik (eBm), 3(1). https://doi.org/10.35790/ebm.v3i1.6620.
Zulfhi, H., & Muflihatin, S. K. (2020). Hubungan kepatuhan minum obat dengan terkendalinya kadar gula darah pada pasien DM tipe II di Irna RSUD Abdul Wahab Sjahranie Samarinda. Borneo Student Research, 1(3), 1679-1686.
Published
2024-09-12
How to Cite
ARIYANTI, Ni Kadek Nining; VIRGINIA, Dita Maria; HENDRA, Phebe.
Hubungan Kepatuhan Terapi Antihiperglikemia Terhadap Terkontrolnya HbA1c pada Pasien Terdiagnosa Diabetes Melitus Tipe 2 di RSU Prima Medika, Denpasar.
Jurnal Farmasi Udayana, [S.l.], p. 1-5, sep. 2024.
ISSN 2622-4607.
Available at: <https://ojs.unud.ac.id/index.php/jfu/article/view/113701>. Date accessed: 27 sep. 2024.
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