Finding Antitubercular Leads from Marine-Derived and Entomopathogenic Fung

  • Ni Luh Putu Indah Suryani Department of Pharmacy, Faculty of Mathematics and Natural Sciences, Udayana University, Kampus Unud Bukit-Jimbaran, Badung, 80361 Bali, Indonesia
  • I Putu Yogi Astara Putra Master Program in Biology, Faculty of Mathematics and Natural Sciences, Udayana University, Denpasar, Bali, Indonesia
  • Nonye Treasure Ujam Department of Pharmaceutical Microbiology and Biotechnology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology (ESUT), Enugu State 401105, Nigeria
  • Ni Putu Ariantari Program Studi Profesi Apoteker, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana, Kampus Bukit Jimbaran, Badung, Bali, 80361
DOI: https://doi.org/10.24843/JFU.2023.v12.i01.p09

Abstract

The occurrence of Mycobacterium tuberculosis resistance encourages the discovery of new antitubercular candidates. Microbes including fungi and bacteria are well known reservoir for isolating antibiotic compounds, among natural product resources. In this review, we report promising antitubercular compounds from marine-derived and entomopathogenic fungi, reported from 2000 to 2022. A comprehensive literature search was conducted through scientific websites, including Google Scholar, Springer, and Pubmed. Eighty-three antitubercular compounds were reported, where 57 of them derived from fungi associated with marine ecosystem. Those fungi belong to 10 fungal genera. The remaining active compounds were isolated from 7 genera of entomopathogenic fungi. Gliotoxin, 12,13-dihydroxy-fumitremorgin, and helvolic acid as well as hirsutellones A-D are among bioactive compounds reported for their remarkable antitubercular activity, which promising to be investigated further in the search of antitubercular leads. Deeper investigation on these compounds might be promising for the the discovery of antitubercular candidates in the future.


Keywords: Antitubercular; entomopathogenic fungi; marine-derived fungi; Mycobaterium tuberculosis; secondary metabolites

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Published
2023-08-28
How to Cite
SURYANI, Ni Luh Putu Indah et al. Finding Antitubercular Leads from Marine-Derived and Entomopathogenic Fung. Jurnal Farmasi Udayana, [S.l.], p. 52-62, aug. 2023. ISSN 2622-4607. Available at: <https://ojs.unud.ac.id/index.php/jfu/article/view/102803>. Date accessed: 05 nov. 2024. doi: https://doi.org/10.24843/JFU.2023.v12.i01.p09.
Citation Formats
Issue
Vol. 12, No 1, Tahun 2023
Section
Articles