ANALISIS SENYAWA TERPENOID ANTIJAMUR PADA FRAKSI AKTIF EKSTRAK KULIT KAYU CEMPAKA PUTIH (MICHELIA ALBA) DENGAN METODE GAS CHROMATOGRAPHY-MASS SPECTROSCOPY

  • I G. A. G. Bawa Program Studi Kimia FMIPA Universitas Udayana, Jimbaran, Bali, Indonesia
  • I G. A. G. C. A. Perbhawa Program Studi Farmasi, Fakultas Matematika dan Ilmu Pengetahuan Alam, Universitas Udayana, Jimbaran, Badung, Bali, Indonesia
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Abstrak

       The bark extract of Michelia alba was able to inhibit the growth of Curvularia verruculosa fungus which was isolated from leaf spot disease in rice. Separation of the active compound was carried out by column chromatography method using the stationary phase of silica gel and the mobile phase of a mixture of n-hexane-acetone (3: 1). Separation of the active extracts resulted in 10 combined fractions, where 4 fractions showed very strong inhibition, namely the HAE fraction (31.50 mm), HAF (30.13), HAG (48.50), and HAH (34.88). The composition of terpenoid compounds in these fractions was analyzed by Gas Chromatography-Mass Spectrometry. The compound ledenoxid (II) and isoaromadendrene epoxide werefound in almost all of the active fractions, while spathulenol wasfound in the HAF and HAG fractions. Other terpenoid compounds found werecis-farnesol, trans-p-mentha-1 (7), 8-dien-2-ol, and neoclovenoxid-alcohol in the HAE fraction, (-)-caryophyllene oxide and tomentosin in the fraction of HAG. All of the detected terpenoid compounds were compounds from the sesquiterpene group.


Keywords: Michelia alba extract, inhibitory power, Curvularia verruculossa, sesquiterpenes

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Diterbitkan
2020-07-31
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BAWA, I G. A. G.; PERBHAWA, I G. A. G. C. A.. ANALISIS SENYAWA TERPENOID ANTIJAMUR PADA FRAKSI AKTIF EKSTRAK KULIT KAYU CEMPAKA PUTIH (MICHELIA ALBA) DENGAN METODE GAS CHROMATOGRAPHY-MASS SPECTROSCOPY. Jurnal Kimia (Journal of Chemistry), [S.l.], p. 142-146, july 2020. ISSN 2599-2740. Tersedia pada: <https://ojs.unud.ac.id/index.php/jchem/article/view/61696>. Tanggal Akses: 14 oct. 2025 doi: https://doi.org/10.24843/JCHEM.2020.v14.i02.p06.
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