PENGARUH KONSENTRASI GELLING AGENT TERHADAP DIFUSI SEDIAAN GEL VITAMIN C DENGAN METODE SEL DIFUSI FRANZ
Abstrak
Diffusion defined as a process of molecular displacement due to the difference in molecular concentration through a semipermeable membrane. The aim of diffusion test is know effect of the amount of gelling agent on the diffusion of vitamin C. The diffusion test of vitamin C gel preparation was measured by using Franz diffusion cell and the rate was analyzed by iodometric titration. Based on the results obtained that within 5, 10, 20 and 30 minutes, the amount of diffusion of 1% vitamin C gel preparation was 378,5 mg; 108,71 mg; 223.33 mg; 3442,13 mg while for 2% sample was 269 mg; 431.64 mg; 475.07 mg; 574,11 mg and for sample 3% was 543 mg; 594,08 mg; 646,27 mg; and 700,77 mg. Based of this, the release of vitamin C gel preparation is proportional to the time given, the longer time given then the release of vitamin C gel preparation is more increase. The effect of gelling agent on the diffusion of vitamin C gel preparation is the higher the concentration of gelling agent, decreasing the level in the receptor compartment obtained.
Keywords: diffussion, concentration, gelling agent, gel of vitamin C
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Referensi
Cipta, N. A., Soebagio, B. dan Sriwidodo. 2011. Pengaruh Propilen Glikol terhadap Laju Difusi Krim Natrium Diklofenak dengan Basis Hidrofobik secara In Vitro. J. Trop. Pharm. Chem. 1(1):8-16Deferme, S., Annaert, P., dan Augustijns, P. 2008. In Vitro Screening Models To Asses Intestinal Drug Absorption and Metabolism. New York: APPS Press.
Gandjar, I. G. dan A. Rohman. 2010. Kimia Farmasi Analisis. Yogyakarta: Pustaka Pelajar.
Hidayati, D. N., Felasufah, U., Nurfitriani, A. A., & Mufrod, M. 2018. Aktivitas Antijamur Krim Ekstrak Etanol Daun Jambu Monyet (Anacardium occidentale L.) dan Kulit Batang Rambutan (Nephelium lappaceum) terhadap Candida albicans. JIFFK: Jurnal Ilmu Farmasi dan Farmasi Klinik, 14(2), 25-30.
Kuntari, F. R., Pranoto, S. dan Sutresno, A. 2019. Studi Proses Difusi melalui Membran dengan Pendekatan Kompartemen. J.Fis. dan Apl. 15(2):62-65.
Putri, M.P. dan Y.H. Setiawati. 2015. Analisis Kadar Vitamin C Pada Buah Nanas Segar (Ananas Comosus (L.) Merr) dan Buah Nanas Kaleng Dengan Metode Spektrofotometri Uv-Vis. Jurnal Wiyata 2(1): 1-10.
Putri, R. A.. 2016. Uji Disolusi, Uji Difusi (in-vitro) dan Penetapan Kadar Tablet Ranitidin Generik dan Generik Bermerek. Jakarta: UIN Syarif Hidayatullah.
Simon, P.. 2012. Formulasi dan Uji Penentrasi Mikroemulsi Natrium Diklofenak dengan Merode Sel Difusi Franz dan Metode Tape Stripping. Skripsi. Jakarta: Universitas Indonesia.
Ulfa, A. M.. 2015. Penetapan Kadar Klorin (Cl2) pada Beras Menggunakan Titrasi Iodometri. Jurnal Kesehatan Holistik 9(4): 197-200.
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