ISOLASI DAN AKTIVITAS ANTIKANKER PINOSTROBIN DARI TEMU KUNCI (Kaempferia pandurata Roxb) TERHADAP FIBROSARKOMA MENCIT HASIL INDUKSI BENZOPIREN

  • Oka Adi Parwata
  • Sukardiman Sukardiman
  • Alit Widhiartini

Abstract

Induction of apoptosis and antiangiogenesis effects of Pinostrobin from Kaempferia pandurata Roxb against Fibrosarkoma mice induced with benzopiren have been investigated. Examination begins with taking tissue of fibrosarcoma in mice infected and weighing the fibrosarcoma obtained. Fibrosarcoma tissues were then stored in 10 % formalin. Weighing results showed that pinostrobin oral concentration of 80 mg/kg can inhibit 68.62 % growth of fibrosarcoma. It was also shown that cancer drug (positive control) resulted in 95.95 % inhibition compared to the negative control. This means pinostrobin can potentially be developed as a cancer chemotherapy drug.
Patohystology analysis of the fibrosarcoma tissue with HE staining on light microscope with 400x magnification showed many chromatins (polychromatin) which proved the damage caused by the fibrosarcoma cells.

 

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Author Biographies

Oka Adi Parwata

Kelompok Studi Bahan Alam, Laboratorium Kimia Organik, Jurusan Kimia Fakultas Matematika dan Ilmu Pengetahuan Alam  Universitas Udayana, Denpasar Bali

Sukardiman Sukardiman
Laboratorium Fitokimia dan Farmakognosi Fak. Farmasi Universitas Airlangga, Surabaya
Alit Widhiartini
Bagian Farmasi, Fakultas Kedokteran Universitas Udayana, Jln  PB Sudirman, Denpasar
Published
2014-07-01
How to Cite
ADI PARWATA, Oka; SUKARDIMAN, Sukardiman; WIDHIARTINI, Alit. ISOLASI DAN AKTIVITAS ANTIKANKER PINOSTROBIN DARI TEMU KUNCI (Kaempferia pandurata Roxb) TERHADAP FIBROSARKOMA MENCIT HASIL INDUKSI BENZOPIREN. Jurnal Kimia (Journal of Chemistry), [S.l.], july 2014. ISSN 2599-2740. Available at: <https://ojs.unud.ac.id/index.php/jchem/article/view/11766>. Date accessed: 04 nov. 2024. doi: https://doi.org/10.24843/JCHEM.2014.v08.i02.p16.
Section
Articles

Keywords

pinostrobin, fibrosarkoma, Apoptosis, and Antiangiogenesis