Retroperitoneal Pleomorphic Rhabdomyosarcoma in Adult: A Rare Case Report
Abstract
Background: Rhabdomyosarcoma (RMS) is the most common type of soft tissue sarcoma in children, however, RMS is a rare malignancy in adults. Head and neck are the most common site for RMS, while intrabdominal RMS are rare in adults. Case: We present a rare case of a retroperitoneal abdominal mass, treated surgically with histopathology results of a retroperitoneal RMS. We discuss the clinical presentation, image findings, and treatment for this case. Conclusion: Intraabdominal tumours need to be identified quickly and precisely. CT scan or MRI can help clinicians to determine the staging, therefore plans the best treatment for the patient. In our case, surgery and radiotherapy showed promising outcome. The lack of literature and consensus on a standardized approach to systemic treatment and outcome in retroperitoneal pleomorphic RMS in adults makes our case a rare presentation of rhabdomyosarcoma and thus the need for reporting.
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2. Furlong MA, Mentzel T, Fanburg-Smith JC. Pleomorphic rhabdomyosarcoma in adults: A clinicopathologic study of 38 cases with emphasis on morphologic variants and recent skeletal muscle-specific markers. Mod Pathol. 2001;14:595-603.
3. Fletcher CDM, Bridge JA, Hogendoorn PCW, et al. WHO Classification of Tumors of Soft Tissue and Bone, 4th Edition, Volume 5. France: IARC Press; 2013. p.127-34.
4. Sultan I, Qaddoumi I, Yaser S, et al. Comparing adult and pediatric rhabdomyosarcoma in the surveillance, epidemiology and end results program, 1973 to 2005: an analysis of 2,600 patients. J Clin Oncol. 2009;27:3391-7.
5. Alkhormi AM, Alqifari A, Aljarbou OZ, et al. Primary duodenal embryonal rhabdomyosarcoma in adults: a case report. AME Case Rep. 2019;3:29.
6. Kumar H, Heroor A, Vanan A, et al. Intra-Abdominal Retroperitoneal Rhabdomyosarcoma in Adult: A Rare Case Report & Review of Literature. IOSR Journal of Dental and Medical Sciences. 2017;16:36-8.
7. Yadav SK, Sinha DK, Ahmed A, Azhar T, et al. Primary Intra-Abdominal Rhabdomyosarcoma in an Adult: an Unusual Presentation and Review of Literature. Indian J Surg Oncol. 2015;6:119-22.
8. Qadri S, Alam K, Alam F. Retroperitoneal pleomorphic rhabdomyosarcoma metastasizing to inguinal lymph node. Clin Cancer Investig J. 2015;4:404-7.
9. Yu L, Yang SJ. Spindle cell rhabdomyosarcoma of the retroperitoneum: an unusual case developed in a pregnant woman but obscured by pregnancy. Int J Clin Exp Pathol. 2014;7:4904-12.
10. Egas-Bejar D, Huh WW. Rhabdomyosarcoma in adolescent and young adult patients: Current perspectives. Adolesc Health Med Ther. 2014;5:115-25.
11. Rajiah P, Sinha R, Cuevas C, et al. Imaging of uncommon retroperitoneal masses. Radiographics. 2011;31:949-76.
12. Nakayama R, Nemoto T, Takahashi H, et al. Gene expression analysis of soft tissue sarcomas: Characterization and reclassification of malignant fibrous histiocytoma. Mod Pathol. 2007;20:749-59.
13. Khosla D, Sapkota S, Kapoor R, et al. Adult Rhabdomyosarcoma: Clinical Presentation, Treatment, and Outcome. J Cancer Res Ther. 2015;11:830-4.
14. Ferrari A, Dileo P, Casanova M, et al. Rhabdomyosarcoma in adults. A retrospective analysis of 171 patients treated at a single institution. Cancer. 2003;98:571-80.
15. Crist W, Gehan EA, Ragab AH. The third Intergroup Rhabdomyosarcoma Study. J Clin Oncol. 1995;13:610-30.
16. Neville A, Herts BR. CT characteristics of primary retroperitoneal neoplasms. Crit Rev Comput Tomogr. 2004;4:247-70.
17. Husband DJE, Reznek RH. Husband and Reznek's Imaging in Oncology, 3rd Edition. UK: Informa Healthcare; 2009. p.941-6.
18. Bhargavi DV, Avantsa R, Kala P. MDCT signs differentiating retroperitoneal and intraperitoneal lesions-diagnostic pearls. Electronic Presentation Online System. 2015:C-0987.
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