Weight Regain Outcomes in Roux-en-Y Gastric Bypass vs Sleeve Gastrectomy Type of Bariatric Surgery: A Systematic Review and Meta-Analysis pf 13591 Participants

Angeline Asti Shiela Permata; Evelyne Naftali Halim; Juan Aditya; Jeanne Gabrielle Wibowo; Shantidewi Shantidewi; Manarul Iman Alfafa Rachman; Yunita Lestari Indrianto; Aries Budianto

doi:10.24843/JBN.2025.v09.i01.p06

Angeline Asti Shiela Permata Medical Faculty of Brawijaya University, Malang, Indonesia
Evelyne Naftali Halim Medical Faculty of Brawijaya University, Malang, Indonesia
Juan Aditya Medical Faculty of Brawijaya University, Malang, Indonesia
Jeanne Gabrielle Wibowo Medical Faculty of Brawijaya University, Malang, Indonesia
Shantidewi Shantidewi Medical Faculty of Brawijaya University, Malang, Indonesia
Manarul Iman Alfafa Rachman Medical Faculty of Brawijaya University, Malang, Indonesia
Yunita Lestari Indrianto Medical Faculty of Brawijaya University, Malang, Indonesia
Aries Budianto Digestive Surgery Division, Medical Faculty of Brawijaya University/Saiful Anwar General Hospital, Malang, Indonesia

DOI: https://doi.org/10.24843/JBN.2025.v09.i01.p06

Abstract

Aim: Bariatric surgery presents a promising option for obesity treatment worldwide; however, the occurrence of weight regain (WR) post-procedure remains a significant concern. Although WR incidence following bariatric surgery has been well established, research looking specifically at particular types of surgery remains scarce. This study aims to investigate WR outcomes following two of the most popular types of bariatric surgery: Roux-en-Y Gastric Bypass (RYGB) and Sleeve Gastrectomy (SG) following substantial weight loss with a minimum 1-year follow-up. Methods: We systematically searched English-language full-text literature from Pubmed, Cochrane, Wiley Library, Proquest, SpringerLink, and ScienceDirect databases from January 2013 to September 2023. This study was registered to PROSPERO (Registration ID: CRD42023468904). Results: A total of 6 eligible good-quality cohort studies of 13591 patients were included in this meta-analysis. Our findings indicate that RYGB type significantly has less WR events compared to SG type of bariatric surgery, revealing an OR of 0.47 (95% CI: 0.34, 0.65, I² = 80%; p < 0.0001). This research may be taken into account when choosing the type of bariatric surgery a patient will undergo in the future. Conclusion: Our meta-analysis demonstrates that patients undergoing SG type of bariatric surgery are more prone to experience WR in comparison to RYGB type. Further research aimed at identifying associated risk factors would contribute significantly to advance our understanding in this domain.

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