HEXOKINASES IN BREAST CANCER

S. Kharitonov; A. Zikiriahodzhaev; M. Ermoshchenkova; A. Sukhot’ko; M. Fedorova; E. Pudova; B. Alekseev; A. Kaprin; A. Kudryavtseva

doi:10.24843/IJBB.2017.v04.i02.p05

S. Kharitonov Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
A. Zikiriahodzhaev National Medical Research Radiological Center, Ministry of Health of the Russian Federation
M. Ermoshchenkova National Medical Research Radiological Center, Ministry of Health of the Russian Federation
A. Sukhot’ko National Medical Research Radiological Center, Ministry of Health of the Russian Federation
M. Fedorova Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
E. Pudova Engelhardt Institute of Molecular Biology, Russian Academy of Sciences
B. Alekseev National Medical Research Radiological Center, Ministry of Health of the Russian Federation
A. Kaprin National Medical Research Radiological Center, Ministry of Health of the Russian Federation
A. Kudryavtseva Engelhardt Institute of Molecular Biology, Russian Academy of Sciences & National Medical Research Radiological Center, Ministry of Health of the Russian Federation

DOI: https://doi.org/10.24843/IJBB.2017.v04.i02.p05

Abstract

Hexokinases are one of the key enzymes involved in the process of glycolysis. The level of expression of hexokinases is widely studied in breast cancer as a possible marker of unfavorable prognosis and aggressiveness of tumors. The level of expression of hexokinase may reflect the level of glycolysis activation and, thus, indicate samples with the most altered cellular metabolism.

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