HISTOLOGICAL CHANGES OF WHITE RAT’S STOMACH THAT GIVEN YEAST
Abstract
This study aims to determine the histologycal changes of the stomach of white rats given tape yeast. The samples used in this study were 24 female white rats aged 4-5 months, weighing 100-200 grams which were given pelleted feed with the addition of tape yeast. The sample taken was the stomach organ in the corpus region. White rats were grouped into 4 treatments and 6 replications, namely P0: control; P1: giving tape yeast 100 mg/kgBW; P2: 200 mg/kgBW of tape yeast; P3: giving tape yeast 300 mg/kgBW. White rats were dynecropsed on day 22 in all treatment groups. The gastric organs of the corpus region were taken for preparation with Haematoxylin Eosin staining. The variables observed were hemorrhage, inflammation and necrosis. The data obtained were analyzed using the Kruskal-Wallis non-parametric statistical test. If there is a significant difference (P<0.05), the Mann-Whitney test is followed. Based on the results of the Kruskal-Wallis statistical test in all treatment groups there was no significant difference (P>0.05) between the P0 control group and the P1, P2, and P3 treatment groups used. So, it can be concluded that the use of doses of 100 mg/kgBW, 200 mg/kgBW, 300 mg/kg BW has no significant effect on the damage to the gastric organs caused. This could be because the fermentation process of feed mixed with yeast in the stomach is not optimal.
Downloads
References
Alcena V. 2008. The Best Women’s Health. Universe. Bloomington.
Goodman, Gilman. 2008. Farmakologi dan Toksikologi Etanol. In: Brunton LL, Parker KL, Blumenthal DK, Buxton ILO, editor. Manual Farmakologi dan Terapi. Alih Bahasa: Sukandar EY, Adnyana IK, Sigit JI, Sasongko LDN, Anggadiredja K. Jakarta: Penerbit buku kedokteran EGC. Pp.346-51.
Hehi FK, Loho L, Durry MF. 2013. Gambaran histologi lambung tikus wistar pasca pemberian metanol. J. e-Biomedik (eBM). 1(2): 890-895.
Jhonprimen HS, Turnip A, Dahlan MH. 2012. Pengaruh massa ragi, jenis ragi dan waktu fermentasi pada bioetanol dari biji durian. J. Tek. Kim. 18: 43–51.
Juwana S. 2004. Gangguan Mental dan Perilaku Akibat Penggunaan Zat Psikoaktif. EGC. Jakarta. Pp. 157-207.
Manzo AS, Alfredo SM. 2019. Cellular and mitochondrial effects of alcohol consumption. Int. J. Environ. Res. Pub. Health. 7(12): 4281-304.
Mujdalifah S. 2016. Pengaruh ragi tradisional Indonesia dalam proses fermentasi santan terhadap karakteristik rendemen, kadar air, dan kadar asam lemak bebas virgin coconut oil (VCO). Vortech. 1(1): 10-15.
Oktaviana YA, Dadang S, Endang S. 2015. Pengaruh Ragi Tape terhadap pH, Bakteri Asam Laktat dan Laktosa Yogurt. Fakultas Pertanian, Universitas Bengkulu.
Onyeka AV, Nwaehujor CO, Ukagwu AL, Nwogwu IC. 2015. Effects of chronic alcohol ingestion on visceral organs in albino mice experimentally challenged with Escherichia coli strain 0157:H7. Am. J. Pharmacol. Sci. 3(1): 25-32.
Rahmana, Taufiq A. 2003. Aflatoksin: senyawa racun pada biji kacang tanah. Bulletin Tani Tanaman Pangan dan Hortikultura.
Saad N. 2001. Aflatoksin Occurance and Health Risk. An undergraduate student Cornell University for The AS625 Class. Animal Science at Cornell University. USA.
Shafira AN, Kairupan CF, Durry MF. 2016. Gambaran histologik lambung tikus Wistar (Rattus norvegicus) yang diinduksi asam mefenamat dan diberi susu kental manis. J. e-Biomedik (eBm). 4(2).
Sudira IW, Merdana IM, Winaya IBO, Parnayasa IK. 2019. Perubahan histologi ginjal tikus putih diberikan ekstrak sarang semut diinduksi parasetamol dosis toksik. Bul. Vet.Udayana. 11(2): 136-142.
Tarigan P. 2009. Tukak gaster. In: Sudoyo AW, Setiyohadi B, Alwi I, Simadibrata MK, Setiati S, editor. Buku Ajar Ilmu Penyakit Dalam (Edisi Kelima). Jakarta: Interna Publishing. Pp.514-5.
Tenri A. 2015. Laporan Lengkap Anatomi Fisiologi Sistem Pencernaan. d15.blogspot.co.id/2015/01/laporan-ngkap-anatomifisiolgi.html.diakses pada sabtu.
Usmana AS, Rianda S, Novia. 2012. Pengaruh volume enzim dan waktu fermentasi terhadap kadar etanol (Bahan baku tandan kosong kelapa sawit dengan pretreatment alkali). J. Ilm. Teknik Mesin. 18(2): 17-25.
Valeri DC, Berata KB. 2019. Perubahan histologi uterus pada tikus putih (Rattus novergicus) akibat pemberian ragi tape. Indon. Med. Vet. 8(3): 338-346.
Wienanto R. 2008. Hubungan antara infeksi Brucella abortus dengan Somatic Cell Count pada Sapi Perah di Daerah Pusat Penghasil Susu Jawa Timur. Universitas Airlangga.
Wulandari MA, Samsuri, Berata KB. 2019. Pengaruh pemberian ragi tape pada pakan tikus terhadap perubahan histologi ovarium tikus putih (Rattus novergicus). Denpasar. Indon. Med. Vet. 8(3): 338-347.
