USE OF FRUIT CHLOROFORM PARTISI PARE THE WHITE RAT HYPERGLYCEMIC

  • Yoana Pratiwi Clara Pakpahan
  • I Nyoman Suartha
  • Made Suma Anthara
  • Luh Made Sudimartini
  • Anak Agung Gde Oka Dharmayudha

Abstract

This study aimed to determine the efficacy of administration chloroform extract of bitter melon fruit partition to decrease blood glucose levels of hyperglycemic rat (Rattus norvegicus). Measurement of blood glucose levels was done before and streptozotocin injected on days -1, 0, 4, 11, and 18 after mice hyperglycemia. Treatment of bitter melon extract and chloroform partition performed after mice hyperglycemia until day 18th. This study consisted of four treatments and five repetitions using a completely randomized design. Four of this treatment is the control of rats (P0), streptozotocin-treated rat with a dose of 40 mg kg (P1), streptozotocin-treated rat with a dose of 40 mg/kg and bitter melon extract 2% (200 mg/kg) (P2) and streptozotocin-treated rat at a dose of 40mg/kg and chloroform partition 50 mg/kg (P3). The results showed that administration of chloroform partition and bitter melon fruit extract significantly ( P <0.05) to decrease the body's blood glucose levels.

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Author Biographies

Yoana Pratiwi Clara Pakpahan

Veterinarian practitioners in Medan

I Nyoman Suartha

Laboratory of internal veterinarian medicine, Faculty of Veterinary Medicine

Made Suma Anthara

Laboratory of Veterinary Pharmacology and Pharmacy, Udayana University

Luh Made Sudimartini

Laboratory of Veterinary Pharmacology and Pharmacy, Udayana University

Anak Agung Gde Oka Dharmayudha

Laboratory of Veterinary Surgery and Radiology, Udayana University

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Published
2017-02-04
How to Cite
PAKPAHAN, Yoana Pratiwi Clara et al. USE OF FRUIT CHLOROFORM PARTISI PARE THE WHITE RAT HYPERGLYCEMIC. Buletin Veteriner Udayana, [S.l.], feb. 2017. ISSN 2477-2712. Available at: <https://ojs.unud.ac.id/index.php/buletinvet/article/view/28728>. Date accessed: 15 july 2020.
Section
Articles

Keywords

Hiperglikemia; Momordica charantia; Rattus norvegicus

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