STUDI AKTIVITAS ANTIBAKTERI DARI EKSTRAK DAN METABOLIT SEKUNDER JAMUR ENDOFIT GENUS FUSARIUM
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Abstract
Senyawa bahan alam (natural products) merupakan senyawa kimia atau zat yang diproduksi dari organisme hidup, salah satunya berasal dari mikroorganisme. Diantara berbagai jenis mikroorganisme, jamur endofit merupakan salah satu organisme yang diteliti secara intensif dalam dua dekade terakhir. Jamur endofit adalah mikroorganisme yang hidup di dalam jaringan tanaman, seperti bunga, akar, daun, batang, hingga biji, dan tidak merugikan inangnya. Salah satu jamur endofit yang dikaji bioaktivitasnya berasal dari genus Fusarium. Fusarium merupakan salah satu genus jamur yang berfilamen dan banyak ditemukan pada tumbuhan. Jamur Fusarium dapat berinteraksi dengan tanaman inangnya dengan berbagai cara. Beberapa strain endofit Fusarium diketahui dapat mempengaruhi pertumbuhan tanaman, meningkatkan produktivitas, atau membantu tanaman bertahan dalam kondisi lingkungan yang buruk. Strain endofit Fusarium dilaporkan dapat menghasilkan senyawa bioaktif yang memiliki potensi farmasi atau bioteknologi, seperti senyawa dengan aktivitas antibakteri. Artikel ini mengkaji aktivitas antibakteri dari ekstrak dan metabolit sekunder yang dihasilkan jamur endofit dari genus Fusarium berdasarkan data publikasi ilmiah selama 10 tahun terakhir (2013-2023). Kajian ini disusun berdasarkan studi literatur dari jurnal nasional dan internasional menggunakan basis data Google Scholar dan Science Direct. Pencarian jurnal menggunakan kata kunci seperti “endophytic fungi from Fusarium”, “antibacterial of endophytic fungi from Fusarium”, dan “antimicrobial endophytic Fusarium”. Hasil kajian menunjukkan sebanyak 14 spesies jamur endofit dari genus Fusarium mampu menghasilkan metabolit yang memiliki aktivitas antibakteri. Bioaktivitas antibakteri yang dihasilkan dari metabolit sekunder jamur endofit genus Fusarium tersebut diuji dengan metode difusi dan mikrodilusi. Penggalian senyawa dari jamur endofit genus Fusarium potensial dilakukan dalam upaya penemuan molekul bioaktif antibakteri dari genus ini.
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WIDAYANTI, Ni Komang Asri; PUTRA, I Putu Yogi Astara; ARIANTARI, Ni Putu.
STUDI AKTIVITAS ANTIBAKTERI DARI EKSTRAK DAN METABOLIT SEKUNDER JAMUR ENDOFIT GENUS FUSARIUM.
Prosiding Seminar Nasional Sains dan Teknologi (Senastek), [S.l.], v. 8, n. 1, p. 15-23, dec. 2023.
Available at: <https://ojs.unud.ac.id/index.php/senastek/article/view/109143>. Date accessed: 04 nov. 2024.
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References
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[4] Jin, Z., Gao, L., Zhang, L., Liu, T., Yu, F., Zhang, Z., Wang, B. (2017). Antimicrobial activity of saponins produced by two novel endophytic fungi from Panax notoginseng. Natural Product Research, 31(22), 2700–2703. doi:10.1080/14786419.2017.1292265
[5] Ariantari, N. P., Frank, M., Gao, Y., Stuhldreier, F., Kiffe-Delf, A.-L., Hartmann, R., Proksch, P. (2021). Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense. Tetrahedron, 85, 132065. doi:10.1016/j.tet.2021.132065
[6] Li, J., Xie, S., Ahmed, S., Wang, F., Gu, Y., Zhang, C., Chai, X., Wu, Y., Cai, J., and Cheng, G. (2017). Antimicrobial Activity and Resistance: Influencing Factors, Frontiers in Pharmacology, vol. 8, no. 6. doi:https://doi.org/10.3389/fpHr.2017.00364.
[7] Zuhura N Mwanga, Esther F Mvungi., Donatha D Tibuhwa. (2019). Antimicrobial Activities of Endophytic Fungi Secondary Metabolites from Moringa oleifera (Lam). Tanz. J. Sci. Vol 45(3), 2019
[8] Huan W., Ziyue L., Fangfang D., Yan C., Kaidi Q., Qin X., Huiting L., Jun Z., and Haibo Tan. (2023). Isolation, Identification, and Antibacterial Evaluation of Endophytic Fungi from Gannan navel orange. doi: 10.3389/fmicb.2023.1172629
[9] Dame, Z. T., Silima, B., Gryzenhout, M., & van Ree, T. (2015). Bioactive compounds from the endophytic fungusFusarium proliferatum. Natural Product Research, 30(11), 1301–1304. doi:10.1080/14786419.2015.1053089
[10] Praptiwi, P., Palupi, K. D., Fathoni, A., Wulansari, D., Ilyas, M., and Agusta, A. (2016). Evaluation of Antibacterial and Antioxidant Activity of Extracts of Endophytic Fungi Isolated from Indonesian Zingiberaceous Plants, Nusantara Bioscience, vol. 8, no. 2, pp. 306–311, doi : https://doi.org/10.1357/nusbiosci/n080228
[11] Genilloud, O. (2019). Natural products discovery and potential for new antibiotics. Current Opinion in Microbiology, 51, 81–87. doi:10.1016/j.mib.2019.10.012
[12] Grabka, R., D’entremont, T.W., Adams, S.J., Walker, A.K., Tanney, J.B., Abbasi, P.A., et al. (2022). Fungal Endophytes and Their Role in Agricultural Plant Protection against Pests and Pathogens, Plants, 11:1–29.
[13] Zaman, S., Al-Joufi, F. A., Zafar, M., and Zahoor, M. (2022). Phytochemical, Antimicrobial and Cytotoxic Activities of Gaultheria trichophyllaRoyle, Applied Sciences,vol. 12, no. 14, pp. 6921, doi: 10.3390/app12146921.
[14] Khan, N., Afroz, F., Begum, M. N., Roy Rony, S., Sharmin, S., Moni, F., Sohrab, M. H. (2018). Endophytic Fusarium solani: A rich source of cytotoxic and antimicrobial napthaquinone and aza-anthraquinone derivatives. Toxicology Reports, 5, 970–976. doi:10.1016/j.toxrep.2018.08.016
[15] Ibrahim, S. R. M., Mohamed, G. A., Al Haidari, R. A., Zayed, M. F., El-Kholy, A. A., Elkhayat, E. S., Ross, S. A. (2018). Fusarithioamide B, a new benzamide derivative from the endophytic fungus Fusarium chlamydosporium with potent cytotoxic and antimicrobial activities. Bioorganic & Medicinal Chemistry, 26(3), 786–790. doi:10.1016/j.bmc.2017.12.049
[16] Singh, A., Kumar, J., Sharma, V. K., Singh, D. K., Kumari, P., Nishad, J. H., Kharwar, R. N. (2021). Phytochemical analysis and antimicrobial activity of an endophytic Fusarium proliferatum (ACQR8), isolated from a folk medicinal plant Cissus quadrangularis L. South African Journal of Botany, 140, 87–94. doi:10.1016/j.sajb.2021.03.004
[17] Zhang., Sun., Xu. (2016). Antimicrobi Activity Of Endophytic Fungus Fusarium Sp. Isolated From Medicinal Honeysuckle Plant, 25-30. doi : 10.2298/ABS140401004Z
[18] Sari, N. K. Y., Kawuri, R., Parwanayoni, N. M. S. (2017). Aktivitas Antibakteri Fungi Endofit dari Rimpang Jahe Gajah (Zingiber officinale var. Roscoe) terhadap Methicillin Resistant Staphylococcus aureus (MRSA), Metamorfosa: Journal of Biological Sciences. doi: https://doi.org/10.24843/metamorfosa.2020.v07.i02.p11.
[19] Kyekyeku, J. O., Kusari, S., Adosraku, R. K., Bullach, A., Golz, C., Strohmann, C., Spiteller, M. (2017). Antibacterial secondary metabolites from an endophytic fungus, Fusarium solani JK10. Fitoterapia, 119, 108–114. doi:10.1016/j.fitote.2017.04.007
[20] Deshmukh, R., Mathew, A., Purohit, H. J. (2014). Characterization of antibacterial activity of bikaverin from Fusarium sp. HKF15. Journal of Bioscience and Bioengineering, 117(4), 443–448. doi:10.1016/j.jbiosc.2013.09.017
[21] Liu, P., Zhang, D., Shi, R., Yang, Z., Zhao, F., Tian, Y. (2019). Antimicrobial potential of endophytic fungi from Astragalus chinensis. 3 Biotech, 9(11). doi:10.1007/s13205-019-1948-5
[22] Zhang, P., Yuan, X.-L., Du, Y., Zhang, H.-B., Shen, G.-M., Zhang, Z.-F., xu, kuo. (2019). Angularly Prenylated Indole Alkaloids with Antimicrobial and Insecticidal Activities from an Endophytic Fungus Fusarium sambucinum TE-6L. Journal of Agricultural and Food Chemistry. doi:10.1021/acs.jafc.9b05827
[23] Toghueo, R. M. K. (2019). Bioprospecting endophytic fungi from Fusarium genus as sources of bioactive metabolites. Mycology, 11(1), 1–21. doi:10.1080/21501203.2019.1645053
[25] Grijseels, S., Nielsen, J. C., Nielsen, J., Larsen, T. O., Frisvad, J. C., Nielsen, K. F., Workman, M. (2017). Physiological characterization of secondary metabolite producing Penicillium cell factories. Fungal Biology and Biotechnology, 4(1). doi:10.1186/s40694-017-0036-z
[26] Tejesvi, M. V., Segura, D. R., Schnorr, K. M., Sandvang, D., Mattila, S., Olsen, P. B., Pirttilä, A. M. (2013). An antimicrobial peptide from endophytic Fusarium tricinctum of Rhododendron tomentosum Harmaja. Fungal Diversity, 60(1), 153–159. doi:10.1007/s13225-013-0227-8.
[27] Othman, L., Sleiman, A., Abdel-Massih, R. M. (2019). Antimicrobial Activity of Polyphenols and Alkaloids in Middle Eastern Plants. Frontiers in Microbiology, 10. doi:10.3389/fmicb.2019.00911
[28] Anisha, C., Radhakrishnan, E. K. (2017). Metabolite analysis of endophytic fungi from cultivars of Zingiber officinale Rosc. identifies myriad of bioactive compounds including tyrosol. 3 Biotech, 7(2). doi:10.1007/s13205-017-0768-8
[29] Ratnaweera, P. B., de Silva, E. D., Williams, D. E., Andersen, R. J. (2015). Antimicrobial activities of endophytic fungi obtained from the arid zone invasive plant Opuntia dillenii and the isolation of equisetin, from endophytic Fusarium sp. BMC Complementary and Alternative Medicine, 15(1). doi:10.1186/s12906-015-0722-4
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