Antifungal Activity of Saponin White Cambodia Flower (Plumeria acuminata) on Candida albicans ATCC 10231

  • Ni Kadek Yunita Sari Universitas Dhyana Pura
  • Ni Luh Utari Sumadewi

Abstract

      Candida albicans is the main cause of candidiasis in Indonesia. Cases of infection due to Candida fungus have increased globally due to increasing cases of HIV / AIDS infection. White Cambodia is one type of plant that has various properties as a medicinal plant. So far several studies related to the effectiveness of natural antifungi have been carried out on the leaves of white frangipani plants. The effectiveness of antifungi in other white frangipani plant organs such as flowers is still rarely reported. The purpose of this study was to determine the saponin compound content of white frangipani flowers (Plumeria acuminata) and the effectiveness of these compounds on the growth of Candida albicans. The method used in this study: identification of antifungal saponin compounds was carried out by foam testing. Antifungal effectiveness test of saponin compounds on the growth of Candida albicans was tested by the Kirby-Bauer method. Quantitative data of inhibition zone diameters formed in each treatment were analyzed using ANOVA (Analysis of Variance) level of 5%. ANOVA analysis results were significantly different (P <0.05) followed by Duncan's test to see differences between treatments. The results showed that white frangipani saponins (Plumeria acuminata) had antifungal activity on Candida albicans as indicated by the emergence of a 7.7 mm inhibition zone (medium category).


 


Keyword: Candida albicans, Acacia auriculiformis, antifungal, saponin

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Author Biography

Ni Luh Utari Sumadewi

      Candida albicans is the main cause of candidiasis in Indonesia. Cases of infection due to the fungus C. albicans have increased globally. Treatment of diseases caused by fungal infections has been widely carried out using synthetic antifungals. The use of synthetic antifungals has limitations, such as severe side effects, narrow spectrum of antifungals, poor penetration of certain tissues and the emergence of resistant fungi. One alternative that can be done is to use plants as natural anti-fungi. The efficacy of medicinal plants is generally caused by the activity of secondary metabolite compounds produced from plants. Saponin is a secondary metabolite compound that functions as an anti-fungal. Frangipani flower has medicinal properties, the effectiveness of antifungal saponins in white frangipani flowers is rarely reported. The purpose of this study was to determine the saponin content of white frangipani flowers (Plumeria acuminata) and the effectiveness of these compounds in the growth of C. albicans. The method used in this study: identification of saponin antifungal compounds was carried out by foam testing. The antifungal effectiveness test of saponin compounds on the growth of C. albicans was tested by the Kirby-Bauer method. Quantitative data on the diameter of the inhibition zone formed in each treatment were analyzed using ANOVA (Analysis of Variance) at 5% level. The results of ANOVA analysis were significantly different (P <0.05) followed by the Duncan test to see the differences between treatments. The results showed that saponins of white frangipani (P. acuminata) had antifungal activity in C. albicans which was indicated by the formation of an inhibition zone of 7.7 mm (moderate category) so that it could be used as a natural anti-fungal.

 

Keyword: Candida albicans, Acacia auriculiformis, antifungal, saponin

Published
2021-03-30
How to Cite
SARI, Ni Kadek Yunita; SUMADEWI, Ni Luh Utari. Antifungal Activity of Saponin White Cambodia Flower (Plumeria acuminata) on Candida albicans ATCC 10231. Metamorfosa: Journal of Biological Sciences, [S.l.], v. 8, n. 1, p. 74-80, mar. 2021. ISSN 2655-8122. Available at: <https://ojs.unud.ac.id/index.php/metamorfosa/article/view/62680>. Date accessed: 15 oct. 2025. doi: https://doi.org/10.24843/metamorfosa.2021.v08.i01.p07.
Section
Articles