STABILITY COMPARISON OF TULASI (Ocimum tenuiflorum L.) LEAF GEL HAND SANITIZER USING 0.5% AND 1% CMC-Na

  • Dewa Ayu Made Adnya Swari Clinical Pharmacy, International Bali University, Bali, Indonesia
  • Ni Putu Udayana A Pharmacy, Mahasaraswati University, Bali, Indonesia
  • Ni Made Dharma Shantini S Pharmacy, Mahasaraswati University, Bali, Indonesia
DOI: https://doi.org/10.24843/JPSA.2020.v02.i01.p04

Abstract

Background: Hand sanitizers contain 62% alcohol, softener and moisturizer. High alcohol content is able to irritate and make hands dry. A suitable moisturizer is needed for this preparation. Objective: The aim of this study is to evaluate the physical quality of gel hand sanitizer formulation of Ocimum tenuiflorum with CMC-Na as a gelling agent at a concentration of 0.5% and 1% CMC-Na. Methods: Data were collected at week-0,1,2,3,4, and replication is performed three times at each concentration of each measurement. The test results of the spread and adhesion data analysis using SPSS with a 95% confidence level. Results: Dispersive power and adhesion showed no significant difference (p <0.05) at week 0 and week 4 means second-hand sanitizer gel formulation concentration is not stable. Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) at a concentration of 1% CMC-Na stable from week 0 to week 3, while the concentration of 0.5% CMC-Na change at week 2. Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) with a gelling agent CMC-Na should need to be titrated. Conclusion: Gel hand sanitizer leaves of Tulasi (Ocimum tenuiflorum) that use concentrations of 1% CMC-Na as a gelling agent have a physical quality that is more stable than the organoleptic test concentration of 0.5% CMC-Na.


Keywords: Hand sanitizer, Ocimum tenuiflorum L., CMC-Na, Physical quality evaluation

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Published
2020-06-18
How to Cite
SWARI, Dewa Ayu Made Adnya; UDAYANA A, Ni Putu; SHANTINI S, Ni Made Dharma. STABILITY COMPARISON OF TULASI (Ocimum tenuiflorum L.) LEAF GEL HAND SANITIZER USING 0.5% AND 1% CMC-Na. Journal Pharmaceutical Science and Application, [S.l.], v. 2, n. 1, p. 23-27, june 2020. ISSN 2301-7708. Available at: <https://ojs.unud.ac.id/index.php/jpsa/article/view/60490>. Date accessed: 19 may 2024. doi: https://doi.org/10.24843/JPSA.2020.v02.i01.p04.
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Vol 2 No 1 (2020): Journal Pharmaceutical Science and Application
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