FORMULATION AND CHARACTERIZATION EFFERVESCENT TABLETS OF GAMBIER LEAF EXTRACT (Uncaria gambier Roxb)

  • I Gusti Ngurah Agung Windra Wartana Putra Universitas Bali Internasional
  • Putu Rismayanti Putri Pharmacy Department, Bali International University, Denpasar-Indonesia
  • Ni Putu Wintariani Pharmacy Department, Bali International University, Denpasar-Indonesia
  • Ni Putu Aryati Suryaningsih Pharmacy Department, Bali International University, Denpasar-Indonesia
DOI: https://doi.org/10.24843/JPSA.2024.v06.i01.p04

Abstract

Background: Gambier, also known as the term (Uncaria gambier Roxb), is a plant that has long been cultivated in Indonesia. The components of flavonoid compounds in gambier plants have been widely reported as antioxidants. Using the gambier plant will be more accessible and more practical if it is made in dosage form, one of which is in the form of effervescent tablets. Objective: To determine the physical and chemical characteristics of effervescent tablets of gambier leaf extract (Uncaria gambier Roxb). Methods: Descriptive design, which includes phytochemical screening research, extract quality test, physical and chemical characteristics test of effervescent tablets formulation. Results: Positive gambier leaf extracts contain flavonoid compounds, alkaloids, tannins, and saponins. The average weight uniformity test of the tablet is 1.57 ± 0.02 grams, the average tablet thickness test of the tablet is 0.5±0 cm while a tablet's average diameter is 1.6±0 cm, the fragility test obtained <1%, the average hardness test of the tablet is 4.34±0.02 kg, the solubility time of the tablet obtaining is 1.6 ±0.4 minutes and tablets pH is 5.5±0.2. Conclusion: It is possible to draw the conclusion that the positive gambier leaf extract includes flavonoid components, alkaloids, tannins, and saponins based on the findings of the data previously gathered. The quality test of gambier leaf extract is already qualified, and the test of the characteristics of the physical and chemical properties produced is suitable based on Pharmacopeia Indonesia Standard.


Keywords: Gambier; Extract; Tablet Effervescent

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Published
2024-06-17
How to Cite
PUTRA, I Gusti Ngurah Agung Windra Wartana et al. FORMULATION AND CHARACTERIZATION EFFERVESCENT TABLETS OF GAMBIER LEAF EXTRACT (Uncaria gambier Roxb). Journal Pharmaceutical Science and Application, [S.l.], v. 6, n. 1, p. 31-39, june 2024. ISSN 2301-7708. Available at: <https://ojs.unud.ac.id/index.php/jpsa/article/view/115338>. Date accessed: 21 nov. 2024. doi: https://doi.org/10.24843/JPSA.2024.v06.i01.p04.
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Vol 6 No 1 (2024): Journal Pharmaceutical Science and Application
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Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.