KORELASI ANTARA KADAR MAGNESIUM DENGAN RESISTENSI INSULIN PADA PENDUDUK SUKU BALI DI DESA PEDAWA KABUPATEN BULELENG

Abstract

Magnesium is one of microminerals playing pivotal role in glucose homeostasis and insulin activities. Magnesium plays
a very important role in phosphorylation of insulin receptor. This is an analytical cross-sectional study to determine
the prevalence of hypomagnesium and correlation between magnesium level with insulin resistance, performed in
Pedawa Village Bali at February 2010. Subjects for this study were comprised of 111 people, 45 males (40.5%) and 66
females (59.5%). Prevalence of hypomagnesium is 17.12%. The prevalence of hypomagnesium is higher in geriatric
subjects compare with non geriatric subjects (38.48% vs 10.98%, p = 0.004), is higher in diabetes subjects compare with
non diabetes (60% vs 15.1%, p = 0.035), and higher in subject with metabolic syndrome compare with non metabolic
syndrome (34.78% vs 12.5%, p = 0.025). Because lack on sensitivity of insulin measurement, 87 subjects (78.38%) that
have insulin level < 2  IU/ml can not measured by machine so the level of HOMA-IR of this subjects can not calculated,
and just 24 subjects (21.62%) have insulin level > 2  IU/ml which can measured. From this 24 subjects, there is no
signiÞ cant correlation between magnesium level and insulin resistance (HOMA-IR) (r = -0.1, p = 0.642). In this study,
we found a high prevalence of hypomagnesium in residents of Pedawa Village. The prevalence of hypomagnesium is
higher in geriatrics, diabetes mellitus, and metabolic syndrome subjects. There is no signiÞ cant correlation between
magnesium and insulin resistance (HOMA-IR), may be because lack of subject in this study. Thus further studies with
higher sensitivity of insulin measurement and enough sample of diabetic or metabolic syndrome patients in hospital
settingare needed to determine correlation between magnesium level and insulin resistance.