PENGARUH VITAMIN C TERHADAP KADAR SERUM FERITIN PADA PASIEN GAGAL GINJAL KRONIK DENGAN HEMODILISIS REGULER

Abstract

Hyperferitinemia in chronic kidney disease patients with regular hemodyalisis may caused by repeated transfusion,
excessive iron supplementations, and also inß ammation. Increasing of serum feritin level doesn!t depend on iron reserve
capacity. Hemodialysis patients with no supplementations may lead to several antioxidant components deÞ ciency. Qualitative and
quantitative of vitamin C deÞ ciency may also occur, thus administration 1 " 1.5 gram/week or 300 mg of vitamin C parenterally
every dialysis session was recommended in order to compensate subclinical deÞ ciency.
This study determine whether administration of vitamin C (500 mg, in NaCl 0.9%, every session of hemodialysis in 8
weeks) can decrease serum feritin level in chronic kidney disease patients with regular hemodialysis. Randomized clinical trial,
single-blind of 38 chronic kidney disease patients with regular hemodialysis was recruited based on inclusion and exclusion
criteria. Randomization in group with treatment was done with permuted block randomization. Mean of serum feritin before and
after treatment in every group was compared and analysed with Man-Whitney U test. SigniÞ cancy level () was with p less than
0.05 (p < 0.05).
The result of median and mean for decreasing of serum feritin in group with treatment of 500 mg, vitamin C is 0.00
(-227.00 " 218.00) and 77.85 ± 383.25, respectively. While the result of median and mean for decreasing of serum feritin
control group is 32.00 (-14.00 " 108.00) and 65.85 ± 209.6, respectively. On the analysis indicates median of serum feritin
in group with treatment of vitamin C had less 32 points depends with control group (p = 0.84), Thus, there was no signiÞ cant
difference (p > 0.05) between two groups. From Anova analysis for gender, there was signiÞ cant effect in decreasing of serum
feritin level (p < 0.05).
There was no decreasing of serum feritin level after administration of 500 mg, vitamin C in chronic kidney disease
patients with regular hemodialysis, and sex had signiÞ cant effect in alteration of serum feritin level.