PREVALENSI DAN HUBUNGAN SINDROM METABOLIK DENGAN PENYAKIT GINJAL KRONIK PADA POPULASI DESA LEGIAN, KUTA BALI

Abstract

Metabolic syndrome may relate to pathogenesis of chronic kidney disease (CKD). There is scarce data with regard to that
phenomenon in Indonesian general population. We conduct a study to determine the prevalence of metabolic syndrome and its
relationship with CKD individuals in general population of Legian Village, Bali. An analytical cross sectional study was carried
out in the community of Legian Village, a tourist destination in Bali. Samples were selected through simple random sampling.
Two hundred and eighty four samples (117 males and 107 females, aged 46.1 ± 10.02 years) were included. Prevalence
of hypertension, hypertrigliseridemia, hypoHDL-cholesterol, central obesity, impaired fasting glucose (IFG), obese and CKD
was 14.1%, 38.4%, 25%, 18%, 11.6%, 51.8% and 11.6% respectively. Using bivariate analysis, there were strong and significant
relationship between hypertension (OR 2.6, 95%CI 1.12 to 6.19, p = 0.02) and IFG (OR 5.21; 95%CI 2.23 to 12.13, p = 0.00) with
CKD. Using multivariate logistic regression entering those components of metabolic syndrome into the model, it was consistently
found that hypertension and DM is the associated factors for CKD in the population. There was increasing odds of CKD about
1,0-fold every augment of metabolic syndrome components (OR 1.098; 95%CI 0.83 to 1.44). As our conclusion, hypertension
and IFG are associated factor for CKD in general population. Multiple components increased risk factor for CKD.