PENDEKATAN DIAGNOSIS DAN TERAPI FIBROSIS HATI

  • Tjok Istri Anom S
  • I Dewa Nyoman Wibawa

Abstract

Liver Þ brosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most types
of chronic liver. The gold standard to assess disease severity of liver Þ brosis is liver biopsy, despite noninvasive methods
available today. A noninvasive tool (Þ bro scan) has been developed these days. This tool is similar to ultrasound in assessing
liver elasticity. There are three methods frequently used to assess liver Þ brosis, Ishak score, Metavir score, and Desmet/Scheuer
staging system. The principles of antiÞ brotic therapy are: (a) to treat primary disease; (b) to reduce inß ammation response
or to avoid stimulation of stellate cell activation; (c) to reduce stellate cell activation; (d) to neutralize proliferation response,
Þ brogenic response, contractic response, and/or stellate cell proinß ammation; (e) to stimulate apoptosis of stellate cell; and (f) to
increase degradation of Þ brotic tissue.

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Author Biographies

Tjok Istri Anom S
Bagian/SMF Ilmu Penyakit Dalam FK Unud/RS Sanglah, Denpasar
I Dewa Nyoman Wibawa
Bagian/SMF Ilmu Penyakit Dalam FK Unud/RS Sanglah, Denpasar
How to Cite
ANOM S, Tjok Istri; WIBAWA, I Dewa Nyoman. PENDEKATAN DIAGNOSIS DAN TERAPI FIBROSIS HATI. journal of internal medicine, [S.l.], nov. 2012. Available at: <https://ojs.unud.ac.id/index.php/jim/article/view/3911>. Date accessed: 02 nov. 2024.
Section
Articles

Keywords

liver Þ brosis, Þ bro scan, antiÞ brotic therapy

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