PENDEKATAN DIAGNOSIS DAN TERAPI FIBROSIS HATI
Abstract
Liver Þ brosis is the excessive accumulation of extracellular matrix proteins including collagen that occurs in most typesof chronic liver. The gold standard to assess disease severity of liver Þ brosis is liver biopsy, despite noninvasive methods
available today. A noninvasive tool (Þ bro scan) has been developed these days. This tool is similar to ultrasound in assessing
liver elasticity. There are three methods frequently used to assess liver Þ brosis, Ishak score, Metavir score, and Desmet/Scheuer
staging system. The principles of antiÞ brotic therapy are: (a) to treat primary disease; (b) to reduce inß ammation response
or to avoid stimulation of stellate cell activation; (c) to reduce stellate cell activation; (d) to neutralize proliferation response,
Þ brogenic response, contractic response, and/or stellate cell proinß ammation; (e) to stimulate apoptosis of stellate cell; and (f) to
increase degradation of Þ brotic tissue.
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How to Cite
ANOM S, Tjok Istri; WIBAWA, I Dewa Nyoman.
PENDEKATAN DIAGNOSIS DAN TERAPI FIBROSIS HATI.
journal of internal medicine, [S.l.], nov. 2012.
Available at: <https://ojs.unud.ac.id/index.php/jim/article/view/3911>. Date accessed: 22 nov. 2024.
Section
Articles
Keywords
liver Þ brosis, Þ bro scan, antiÞ brotic therapy