CROSSLINK TELOPEPTIDA C-TERMINAL (CTx) SEBAGAI PETANDA AKTIVITAS SEL OSTEOKLAS PADA OSTEOPOROSIS PASCA MENOPAUSE DEFISIENSI ESTROGEN

Abstract

Osteoporosis occurs due to the increase of active osteoclastic bone resorption activity. This condition favors for bone
mass decreased. The examination of Crosslink Telopeptida C-Terminal (CTx)serum concentration is a good indicator to determine
osteoclastic bone resorption activity. The finding of that biochemical substance in serum indicates that there is increase of
osteoclast cell activity. The aim of the study was to prove that in estrogen deficient post-menopausal women, the CTxwas higher
in the osteoporosis compared than the non-osteoporosis. The study was an analytic-observational study in case-control design,
which was done at Sanglah General Hospital, Denpasar. The sample size was 41 case subjects (osteoporosis) and 41 control
subjects (non-osteoporosis) using paired case-control sample size formula. The t-paired test result were: CTx serum concentration
was higher significantly in case compared than control (0.60 ± 0.22ng/mL vs 0.46 ± 0.16ng/mL; p = 0.004). Therefore from
the study we may conclude that: (1) CTx was higher in the osteoporosis compared than the non-osteoporosis in estrogen deficient
post-menopausal women. (2) Osteoclastic bone resoprtion activity was higher in the osteoporosis compared than the non-osteoporosis
in estrogen deficient post-menopausal women