HUBUNGAN KADAR INTERLEUKIN 6 DENGAN KADAR BESI SERUM PENDERITA ANEMIA PADA PENYAKIT KRONIK

Abstract

Anaemia of chronic disease is the second most prevalence after iron deficiency anaemia. It is a common
problem faced because it decreasing the life quality. The pathofisiology of anaemia of chronic disease is same in
malignancy, chronic infection and chronic inflammation. There is immune driven pathway. Released
proinflammation cytokine cause hypoferemia and hyperferitinaemia which the result is anaemia. The Objective
is to determine the correlation of IL-6 with serum iron and haemoglobin in anaemia of chronic disease patien at
Sanglah General Hospital, Denpasar – Bali. The Cross sectional analytic study performed to search the
correlation of IL-6 with serum iron and haemoglobin. Descriptive statistical test performed to descript the
sample characteristic and the distribution frequency of many variable. Spearman correlation used with p < 0.05
is significant. From 25 samples, there are 12 man (48%) and 13 woman (52%). The mean of samples age is
49.20 ± 17.95 years old. The most prevalence diagnosis is lung TB, 8 samples (32%). The mean of IL-6 is 39.32
± 48.66 pg/mL. The mean of serum iron is 42.48 ± 22.09 ug/mL. The mean of hemoglobin is 10.49 ± 1.47 g/dL.
The mean of feritin is 607.62 ± 841,01 ng/mL. The mean of monocyte count is 0,91 ± 0,95 cell/mm3. The
correlation of IL-6 with serum iron is not significant (r -0.05, p 0325). The correlation of IL-6 with
haemoglobin is not significant too (r -0.027, p=0.898). There are possibility cause, first, the gradation of
malignancy, chronic infection, chronic inflammation is not performed. Second, other inflammation cytokine is
not checked. Comorbid disease also may take a place. We conclude the correlation of IL-6 with serum iron and
haemoglobin is not significant.