HEPATIC ISCHEMIA REPERFUSION INJURY IN SEPSIS: BASIS PATHOGENIC MECHANISMS

  • I Gusti Agung Suryadarma

Abstract

Hepatic ischemia reperfusion injury is a complex patho-physiology with a number contributing factors. Ischemia insult
can lead to sublethal cell injury, which is aggravated by the formation of reactive oxygen from various intracellular sources during
reperfusion. In addition, formation of proinflammatory mediators and the recruitment and activation of macrophages, neutrophil
and lymphocyte can further enhance the injury. Microcirculatory disturbances lead to underperfused areas in the liver and may
cause ischemic injury. Hepatic IR injury involves interaction between different cell types and a variety of cellular and molecular
mechanisms including kupffer cells activation, formation of ROS, release of cytokines and chemokines, neutrophil recruitment,
mitochondrial permeability transition and pH paradox. There are two distinct phase of liver injury after warm ischemic reperfusion,
such as early phases and followed by late phases. Clinical presentation of hepatic ischemic reperfusion injury in sepsis, including
sepsis-associated cholestasis, hepatitis ischemic, cholangitis lenta and progressive sclerosing cholangitis

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Author Biography

I Gusti Agung Suryadarma
Division of Gastroenterology-Hepatology, Department of Internal Medicine, Udayana University-Sanglah Hospital.
How to Cite
SURYADARMA, I Gusti Agung. HEPATIC ISCHEMIA REPERFUSION INJURY IN SEPSIS: BASIS PATHOGENIC MECHANISMS. journal of internal medicine, [S.l.], nov. 2012. Available at: <https://ojs.unud.ac.id/index.php/jim/article/view/3827>. Date accessed: 06 dec. 2024.
Section
Articles

Keywords

Hepatic ischemia