PENYAKIT MIELOPROLIFERATIF

  • Made Putra Sedana
  • T. Ivone Wulansari

Abstract

Myeloproliferative disorder (MPD) represent a group of disease marked by cellular proliferation of one or more
haematologic stem cells which include polycythemia vera, essential thrombocythemia, chronic idiopathic myelofibrosis with
myeloid metaplasia / MMM, hypereosinophillic syndrome / HES, unclassified myeloproliferative disease / U-Mpd, chronic
myelogenous leukemia / CML and chronic neutrophylic leukemia / CNL. The incidence and pathogenesis are still unknown.
Chronicity which alterable to aggressive phase become acute leukemia and clonal cytogenetic abnormalities in erythroblast,
neutrophyl, basophyl, macrophage, megakaryocytes and B-lymphocytes, but not in fibroblast are characteristics of the disease.
Haematopoeisis is marked by autonomically growth and myeloid hyperplasia in bone marrow. Bone marrow aspiration show
trilineage hypercellularity. The complications include thrombotic phenomenon, micro and macrovascular arteries thrombosis,
bleeding phenomenon, hypercatabolism and transformation into acute myelogenous leukemia / AML. Pseudocoagulopathy,
pseudohyperkalemia, pseudohyperacydphosphatemia, pseudohypoglicemia and pseudohypoxemia can be seen.

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Author Biographies

Made Putra Sedana
Divisi ? Sub. Bag. Hematologi Onkologi Medik Lab. ? SMF Penyakit Dalam FK Unair ? RSU Dr Sutomo Surabaya
T. Ivone Wulansari
Divisi ? Sub. Bag. Hematologi Onkologi Medik Lab. ? SMF Penyakit Dalam FK Unair ? RSU Dr Sutomo Surabaya
How to Cite
PUTRA SEDANA, Made; WULANSARI, T. Ivone. PENYAKIT MIELOPROLIFERATIF. journal of internal medicine, [S.l.], nov. 2012. Available at: <https://ojs.unud.ac.id/index.php/jim/article/view/3814>. Date accessed: 22 nov. 2024.
Section
Articles

Keywords

MPD, complications

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