ANTIOXIDANT ACTIVITY TEST OF ANDROGRAPHOLIDE IN BITTER HERBS USING DPPH SCAVENGING
Abstract
Abstract Bitter herbs (Sambiloto) have many pharmacological activities including antioxidant, antidiabetic, anticancer,
antihyperlipidemic and anti-inflammation. Andrographolide is a diterpene compounds contained in bitter herbs. It is known that
andrographolide compound responsible for the pharmacological activity of the bitter herbs. This study investigated DPPH free
radical scavenging activity from andrographolide diterpene lactone. This study was initiated with the isolation of
andrographolide compound from bitter herbs and then testing their DPPH free radical scavenging. The results suggested that
andrographolide had IC50 value of 5.45 mg. This means andrographolide has 50% DPPH inhibition effect, i.e 5.45 mg.
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References
REFERENCES
[1] Pietta P-G., 1999. Flavonoids as Antioxidants, Reviews, J. Nat.
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17
[1] Pietta P-G., 1999. Flavonoids as Antioxidants, Reviews, J. Nat.
Prod., 63, 1035-1042
[2] Wijaya A., 1996. Radikal Bebas dan Parameter Status Antioksidan,
Forum Diagnosticum, Prodia Diagnostic Educational Services, No. 1
: 1-12.
[3] Leong L.P., Shui, G., 2001. An Investigation of Antioxidant Capacity
of Fruits in Singapore Markets, Food Chemistry 76 : 69-75.
[4] Clarkson, P. M., Thompson, H. S. 2000, Antioxidants: what role do
they play in physical activity and health, J. Clin Nutr. Biochem, 72.:
637S-46S.
[5] Prakash A., 2001. Antioxidant Activity, Medallion Laboratories
Analytical Progress, Vol. 19 (2).
[6] Okawa M., Kinjo, J., Nohara, T., Ono, M., 2001. DPPH (1,1-
Diphenyl-2-Picrylhydrazyl) Radical Scavenging Activity of
Flavonoids Obtained from Some Medicinal Plants, Biol. Pharm. Bull
24 (10), 1202-1205.
[7] Huidrom, Sangeeta and Deka, Manab, 2012, Determination of
antioxidant property of Andrographis paniculata, IJDAD, 1(1): 12-
17
Published
2017-02-01
How to Cite
SUSANTI, Ni Made Pitri; WARDITIAN, Ni Kadek; WIRASUTA, I Made Agus Gelgel.
ANTIOXIDANT ACTIVITY TEST OF ANDROGRAPHOLIDE IN BITTER HERBS USING DPPH SCAVENGING.
Journal of Health Sciences and Medicine, [S.l.], v. 1, n. 1, p. 9-11, feb. 2017.
ISSN 2622-0555.
Available at: <https://ojs.unud.ac.id/index.php/jhsm/article/view/34806>. Date accessed: 07 may 2024.
doi: https://doi.org/10.24843/JHSM.2017.v01.i01.p03.
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Articles
