Genotoxin Effect of Composite Resin


At this moment composite resin is the most widely used material for dental restoration. The contentĀ of the resin is a mixture of monomer bisphenol A glycidyl methacrylate (Bis-GMA), trimethylene glycol dimethylmethacrylate (TEGDMA) and urethane dimethacrylate (UDMA) and special particle fillers made of radioopaque glass. Many studies have been conducted to study the biocompatibility of composite resin, especially the cytotoxicity and genotoxicity test. Genotoxicity tests that are often carried out are comet test for DNA damage protection and micronuclei test for protection of genome damage. The monomer content of composite resins can have a genotoxic effect.


Download data is not yet available.


1. Hertzberg IFaI. Cyto- and genotoxicity of dental resin composites in human gingival epithelium progenitor cells as assessed by the single cell gel electrophoresis (comet) assay [University of Oslo; 2017.
2. Kenneth J. Anusavice CS, H. Ralph Rawls. Resin-Based Composites. In: H. RALPH RAWLS P, editor. Phillips Science of Dental Materials. 12 ed: Elsevier; 2012.
3. Five Things You Need To Know About Bulk Fill Composite Resins. Dental Product Report: Bisco; 2017. p. 1-7.
4. Kolle S. Genotoxicity and Carcinogenicity: BASF The Chemical Company; 2012.
5. Kucklick TR. Assessing Biocompatibility: Pacific BioLabs; 2013.
6. Dwi Ramadhani SPdDT. Deteksi Kerusakan DNA pada Sel Limfosit Darah Tepi Manusia dengan Teknik Tes Komet. Buletin Alara 2013;15:53-61.
7. Gharsalli T. Comet Assay on Toxicogenetics; Several Studies in Recent Years on Several Genotoxicological Agents. Journal of Environmental & Analytical Toxicology 2016;06(06).
8. Tadin A, Galic N, Mladinic M, et al. Genotoxicity in gingival cells of patients undergoing tooth restoration with two different dental composite materials. Clin Oral Investig 2014;18(1):87-96.
9. Taubock TT, Marovic D, Zeljezic D, et al. Genotoxic potential of dental bulk-fill resin composites. Dent Mater 2017;33(7):788-95.
10. Visalli G, Baluce B, La Maestra S, et al. Genotoxic damage in the oral mucosa cells of subjects carrying restorative dental fillings. Arch Toxicol 2013;87(1):179-87.
11. Bakopoulou A, Papadopoulos T, Garefis P. Molecular toxicology of substances released from resin-based dental restorative materials. Int J Mol Sci 2009;10(9):3861-99.
12. Schweikl H, Spagnuolo G, Schmalz G. Genetic and cellular toxicology of dental resin monomers. J Dent Res 2006;85(10):870-7.
13. Mathieu Lefeuvre WA, Michel Goldberg, Lena Stanislawski. TEGDMA induces mitochondrial damage and oxidative stress in human gingival fibroblasts. Biomaterials 2005;26(25):5130-37.
How to Cite
SEPTIWIDYATI, Tienneke Riana; AUERKARI, Elza Ibrahim. Genotoxin Effect of Composite Resin. Indonesian Journal of Legal and Forensic Sciences (IJLFS), [S.l.], v. 9, n. 1, p. 8-18, june 2019. ISSN 2657-0815. Available at: <>. Date accessed: 20 may 2022. doi: