HUBUNGAN MUTASI GEN K-RAS TERHADAP RESPON TERAPI PADA PASIEN KANKER KOLOREKTAL DI RSUP PROF. DR. IGNG. NGOERAH TAHUN 2017-2019

  • Putu Arya Rahadi Bramantya Fakultas Kedokteran Universitas Udayana
  • Desak Made Wihandani Medical Faculty Udayana University
  • Ni Nyoman Ayu Dewi Medical Faculty Udayana University
  • I Made Winarsa Ruma Medical Faculty Udayana University

Abstract

K-RAS is one of the most frequently mutated genes found in colorectal cancer cases. The K-RAS gene has about 30%-40% contribution to the formation of colorectal cancer. This research is an analytic observational study with a cross-sectional design to explain the characteristics of patients with colorectal cancer at Prof. dr. IGNG. Ngoerah 2017-2019 and assessed the relationship between K-RAS gene mutations and response to therapy. The results of the chi-square test showing a significant relationship between the type of KRAS gene mutation and the response to therapy where p=0.035 (p<0.05). This shows that there is a significant relationship between mutations in the K-RAS gene in colorectal cancer and the response to therapy in colorectal cancer patients at Prof. Dr. IGNG. Ngoerah General Hospital in 2017-2019.

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Author Biographies

Desak Made Wihandani, Medical Faculty Udayana University

Departemen Biokimia Fakultas Kedokteran Universitas Udayana

Ni Nyoman Ayu Dewi, Medical Faculty Udayana University

Departemen Biokimia Fakultas Kedokteran Universitas Udayana

I Made Winarsa Ruma, Medical Faculty Udayana University

Departemen Biokimia Fakultas Kedokteran Universitas Udayana

Published
2024-03-19
How to Cite
BRAMANTYA, Putu Arya Rahadi et al. HUBUNGAN MUTASI GEN K-RAS TERHADAP RESPON TERAPI PADA PASIEN KANKER KOLOREKTAL DI RSUP PROF. DR. IGNG. NGOERAH TAHUN 2017-2019. E-Jurnal Medika Udayana, [S.l.], v. 13, n. 3, p. 85-90, mar. 2024. ISSN 2303-1395. Available at: <https://ojs.unud.ac.id/index.php/eum/article/view/95826>. Date accessed: 05 nov. 2024. doi: https://doi.org/10.24843/MU.2024.V13.i03.P13.