FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA

  • Ni Komang Tristiana Dewi
  • I Wyn. Sugiritama

Abstract

Androgenetic alopecia (AGA) is a type of alopecia non sikatrik that most often occur, especially in men. AGA is hereditary baldness and form distinctive patterns. Causes related to AGA estimated serum androgen levels, especially 5-?-dehydrotestosterone (DHT), which can lead to miniaturization of the hair follicle. Finasteride is one of drugs that proven effective in treating hair loss caused by AGA. Finasteride is a 4-azasteroid components that are competitive and specific inhibitor of the enzyme 5-?-reductase type II, an enzyme that converts testosteron into intracellular DHT. By inhibiting the enzyme 5-?-reductase type II, conversion of testosteron to DHT inhibited, thereby causing a significant decrease in serum and tissue DHT concentrations. The use of finasteride 1 mg per day proven to effectively treat AGA in men.

 

Author Biographies

Ni Komang Tristiana Dewi

Mahasiswa Fakultas Kedokteran Universitas Udayana

I Wyn. Sugiritama
Bagian Histologi Fakultas Kedokteran Universitas Udayana Denpasar
How to Cite
TRISTIANA DEWI, Ni Komang; SUGIRITAMA, I Wyn.. FINASTERIDE AS A TREATMENT FOR MALE ANDROGENETIC ALOPECIA. E-Jurnal Medika Udayana, [S.l.], p. 580-592, apr. 2013. ISSN 2303-1395. Available at: <https://ojs.unud.ac.id/index.php/eum/article/view/5109>. Date accessed: 24 mar. 2019.

Keywords

finasteride, 5-?-dehydrotestosterone (DHT), androgenetic alopecia