STUDI DESKRIPTIF RISIKO KANKER PAYUDARA PADA KELOMPOK BERISIKO DAN TIDAK BERISIKO DI RUMAH SAKIT UMUM PUSAT SANGLAH 21 – 26 NOVEMBER 2013

I Gusti Putu Benediktus Bosman Ariesta; Ida Bagus Tjakra Wibawa Manuaba

I Gusti Putu Benediktus Bosman Ariesta Program Studi Pendidikan Dokter Fakultas Kedokteran Universitas Udayana
Ida Bagus Tjakra Wibawa Manuaba Bagian/SMF Ilmu Bedah Fakultas Kedokteran Universitas Udayana/RSUP Sanglah

Abstract

DESCRPTIVE STUDY: BREAST CANCER RISK AMONG RISK GROUP AND NON RISK GROUP IN SANGLAH HOSPITAL NOVEMBER 21^st – 26^th 2013

This study evaluates the lifetime risk and BRCA1 and BRCA2 genes mutation risk between risk group and non-risk group. This is a descriptive study. Total 100 respondents according to inclusion criteria are included in this study. The data is obtained from the interview about personal identity and research variable. The calculation of the risk is based on each validated model and analyzed by SPSS 16 for Windows. Average of lifetime risk for risk woman, based on Gail, Claus, Claus Extended, and Cuzick-Tyrer model are 7,85%, 12,82%, 13,13%, dan 14,76% respectively. Average of lifetime risk for non-risk woman based on Gail and Cuzick-Tyrer model are 4,15% and 7,92% respectively. Average mutation risk of BRCA1 and BRCA2 in risk woman are 0,43% dan 0,61% respectively, meanwhile in non-risk woman are 0,07% dan 0,13% respectively. Mutation risk of population are 0,12% and 0,2% respectively. This study suggest higher average of lifetime risk between risk woman and non-risk woman. The risk group have higher mutation risk than population risk, and the non-risk group have lower mutation risk than population risk both BRCA1 and BRCA2.