POTENSI HUMAN EMBRYONIC STEM CELL-DERIVED RETINAL PIGMENT EPITHELIUM SEBAGAI AGEN TERAPI REGENERATIF DRY AGE RELATED MACULAR DEGENERATION
SEBUAH TINJAUAN LITERATUR
Abstract
Pendahuluan: Age related macular degeneration (AMD) adalah salah satu penyakit mata degeneratif pada kelompok usia lanjut akibat degenerasi lapisan epitel pigmen retina (RPE). Degenerasi ini menyebabkan kerusakan pada sel fotoreseptor. AMD merupakan penyebab kebutaan terbanyak di negara maju dan ke tiga secara global. AMD terbagi menjadi 2 tipe, yaitu wet dan dry AMD. Hingga saat ini, belum ada terapi yang terbukti dapat menyembuhkan dry AMD. Oleh sebab itu, masih dibutuhkan inovasi terapi terhadap dry AMD.
Pembahasan: Didapatkan 5 jurnal utama yang berkorelasi dengan pembuatan tinjauan literatur ini dan diperoleh informasi bahwa penggunaan hESCs-RPE mempunyai potensi sebagai terapi regeneratif terhadap RPE. Penggunaan sel punca ini dapat meningkatkan pigmentasi pada retina yang dapat dinilai melalui gambaran funduskopi dan optical coherence tomography (OCT). Hal ini mengindikasikan adanya perbaikan pada RPE dari pasien. Selain itu, didapatkan pula adanya perbaikan visus tanpa adanya tanda-tanda teratoma, reaksi penolakan akut, ataupun infeksi pascatransplantasi.
Simpulan: Penggunaan hESCs-RPE dapat menjadi inovasi terapi dry AMD.
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References
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2. Van Lookeren Campagne M, Lecouter J, Yaspan BL, Ye W. Mechanisms of age-related macular degeneration and therapeutic opportunities. J Pathol [Internet]. 2014 Jan [cited 2021 Nov 26];232(2):151–64. Available from: https://pubmed.ncbi.nlm.nih.gov/24105633/
3. Wong WL, Su X, Li X, Cheung CMG, Klein R, Cheng CY, et al. Global prevalence of age-related macular degeneration and disease burden projection for 2020 and 2040: a systematic review and meta-analysis. Lancet Glob Heal. 2014 Feb 1;2(2):e106–16.
4. Ageing and health [Internet]. [cited 2021 Nov 21]. Available from: https://www.who.int/news-room/fact-sheets/detail/ageing-and-health
5. Kementerian Kesehatan RI. Situasi lansia di Indonesia tahun 2017: Gambar struktur umur penduduk indonesia tahun 2017. Pus Data dan Inf. 2017;1--9.
6. Kemetrian Kesehatan RI. Infodatin “Situasi dan Analisis Lanjut Usia.” Geriatric. 2014. p. 8.
7. Lim LS, Mitchell P, Seddon JM, Holz FG, Wong TY. Age-related macular degeneration. Lancet (London, England) [Internet]. 2012 [cited 2021 Nov 26];379(9827):1728–38. Available from: https://pubmed.ncbi.nlm.nih.gov/22559899/
8. Da Cruz L, Fynes K, Georgiadis O, Kerby J, Luo YH, Ahmado A, et al. Phase 1 clinical study of an embryonic stem cell-derived retinal pigment epithelium patch in age-related macular degeneration. Nat Biotechnol. 2018 Apr 1;36(4):328–37.
9. Schwartz SD, Regillo CD, Lam BL, Eliott D, Rosenfeld PJ, Gregori NZ, et al. Human embryonic stem cell-derived retinal pigment epithelium in patients with age-related macular degeneration and Stargardt’s macular dystrophy: Follow-up of two open-label phase 1/2 studies. Lancet [Internet]. 2015;385(9967):509–16. Available from: http://dx.doi.org/10.1016/S0140-6736(14)61376-3
10. Uyama H, Mandai M, Takahashi M. Stem-cell-based therapies for retinal degenerative diseases: Current challenges in the establishment of new treatment strategies. Dev Growth Differ [Internet]. 2021 Jan 1 [cited 2021 Nov 21];63(1):59–71. Available from: https://pubmed.ncbi.nlm.nih.gov/33315237/
11. Liu Y, Xu HW, Wang L, Li SY, Zhao CJ, Hao J, et al. Human embryonic stem cell-derived retinal pigment epithelium transplants as a potential treatment for wet age-related macular degeneration. Cell Discov [Internet]. 2018 Dec 1 [cited 2021 Nov 21];4(1). Available from: https://pubmed.ncbi.nlm.nih.gov/30245845/
12. Carr AJF, Smart MJK, Ramsden CM, Powner MB, da Cruz L, Coffey PJ. Development of human embryonic stem cell therapies for age-related macular degeneration. Trends Neurosci [Internet]. 2013;36(7):385–95. Available from: http://dx.doi.org/10.1016/j.tins.2013.03.006
13. Desai N, Rambhia P, Gishto A. Human embryonic stem cell cultivation: Historical perspective and evolution of xeno-free culture systems. Reprod Biol Endocrinol. 2015;13(1):1–15.
14. Damdimopoulou P, Rodin S, Stenfelt S, Antonsson L, Tryggvason K, Hovatta O. Human embryonic stem cells. Best Pract Res Clin Obstet Gynaecol [Internet]. 2016;31:2–12. Available from: http://dx.doi.org/10.1016/j.bpobgyn.2015.08.010
15. Schwartz SD, Hubschman JP, Heilwell G, Franco-Cardenas V, Pan CK, Ostrick RM, et al. Embryonic stem cell trials for macular degeneration: a preliminary report. Lancet (London, England) [Internet]. 2012 [cited 2021 Nov 26];379(9817):713–20. Available from: https://pubmed.ncbi.nlm.nih.gov/22281388/
16. Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, et al. Stem cell based therapies for age-related macular degeneration: The promises and the challenges. Prog Retin Eye Res [Internet]. 2015 Sep 1 [cited 2021 Dec 15];48:1–39. Available from: https://pubmed.ncbi.nlm.nih.gov/26113213/
17. Song K, Park K-M, Kim H-J, Lee JH, Choi J, Chong SY, et al. Stem Cell Reports Ar ticle Treatment of Macular Degeneration Using Embryonic Stem Cell-Derived Retinal Pigment Epithelium: Preliminary Results in Asian Patients. Stem Cell Reports [Internet]. 2015 [cited 2021 Nov 27];4:860–72. Available from: http://dx.doi.org/10.1016/j.stemcr.2015.04.005ThisisanopenaccessarticleundertheCCBYlicense
18. Tabatabaei SA, Soleimani M, Vakili H, Naderan M, Lashay A, Faghihi H, et al. The rate of endophthalmitis after pars plana vitrectomy and its risk factors. Int Ophthalmol [Internet]. 2019;39(6):1299–305. Available from: https://doi.org/10.1007/s10792-018-0944-9
Published
2023-04-11
How to Cite
WINARTA, Sanjaya; KURNIA, Karen; MUNDI, Gabriella Novelin.
POTENSI HUMAN EMBRYONIC STEM CELL-DERIVED RETINAL PIGMENT EPITHELIUM SEBAGAI AGEN TERAPI REGENERATIF DRY AGE RELATED MACULAR DEGENERATION.
Essential: Essence of Scientific Medical Journal, [S.l.], v. 20, n. 2, p. 22-26, apr. 2023.
ISSN 2655-6472.
Available at: <https://ojs.unud.ac.id/index.php/essential/article/view/85260>. Date accessed: 19 may 2024.
doi: https://doi.org/10.24843/essential.v20i2.85260.
Section
Artikel Tinjauan Pustaka
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