Potensi Photodynamic Therapy (PDT) Berbasis Inhalable Curcumin sebagai Modalitas Terapi COVID-19
Abstract
Pendahuluan: COVID-19 telah menjadi krisis kesehatan baru yang mengancam dunia. Upaya preventif seperti edukasi dan vaksinasi telah dilakukan. Satu-satunya pilihan yang tersedia adalah penggunaan obat antivirus spektrum luas, tetapi beberapa obat tersebut cenderung mahal dan memiliki efek samping yang berbahaya. Curcumin memiliki efek terapeutik potensial untuk COVID-19 karena efek antivirus dan anti-inflamasinya. Curcumin dapat dikemas dalam bentuk inhalable dengan memformulasinya menjadi bubuk kering. Penggunaan photodynamic therapy (PDT) dapat meminimalisasi toksisitas sistemik dan efek samping yang tidak diinginkan.
Pembahasan: Curcumin telah terbukti menghambat replikasi virus dengan menghambat glikoprotein S dan ACE 2, menghambat aksi TMPRSS2, Main protease (Mpro), dan menurunkan ekspresi pompa vakuolar (ATPase). Curcumin juga dapat menurunkan respon inflamasi dengan menghambat aktivasi translokasi NF-kB yang dimediasi STAT3. Formulasi terapi inhalasi Curcumin sebagai produk serbuk kering dapat meningkatkan bioavailabilitas Curcumin dan kepatuhan pasien. Curcumin-PDT pada sel Vero yang terinfeksi SARS-CoV2 memberikan efek anti-COVID-19 secara in vitro tanpa menyebabkan sitotoksisitas dan apoptosis dalam sel, dan tidak memiliki efek buruk pada kualitas plasma.
Simpulan: Inhalable Curcumin berbasis terapi fotodinamik berpotensi sebagai inovasi terapi COVID-19.
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References
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18. Ma Z, Wang N, He H, Tang X. Pharmaceutical strategies of improving oral systemic bioavailability of curcumin for clinical application. Journal of Controlled Release. 2019 Dec 28;316:359-80.
19. Chvatal A. Formulation and aerodynamic evaluation of carrier-free dry powder inhalation systems containing meloxicam. International Journal of Pharmaceutics. 2019;559:68-75.
20. Pourhajibagher M, Azimi M, Haddadi-asl V, Ahmadi H. Robust antimicrobial photodynamic therapy with curcumin-poly (lactic-co-glycolic acid) nanoparticles against COVID-19: A preliminary in vitro study in Vero cell line as a model. Photodiagnosis Photodyn Ther. 2021;34(1–12).
21. Alves LA, Ferreira LB, Pacheco PF, Mendivelso EA, Teixeira PC, Faria RX. Pore forming channels as a drug delivery system for photodynamic therapy in cancer associated with nanoscintillators. Oncotarget. 2018 May 18;9(38):25342.
22. Susilo A, Rumende CM, Pitoyo CW, Santoso WD, Yulianti M, Sinto R, et al. Coronavirus Disease 2019 : Tinjauan Literatur Terkini Coronavirus Disease 2019 : Review of Current Literatures. 2020;7(1):45–67.
23. Wang Z, Qiang W, Ke H. A Handbook of 2019-nCoV Pneumonia Control and Prevention. Hubei Sci Technol Press. 2020;1–108.
24. Roberts N, Brown R, Buja L, Weerasinghe P. Molecular Mechanisms of Curcumin in COVID-19 Treatment and Prevention: A Global Health Perspective. Med Res Arch. 2020;8(10).
25. Zhang T, Wu Q, Zhang Z. Probable Pangolin Origin of SARS-CoV-2 Associated with the COVID-19 Outbreak. Curr Biol. 2020;30(7):1346-1351.e2.
26. Li G, Fan Y, Lai Y, Han T, Li Z, Zhou P, et al. Coronavirus infections and immune responses. J Med Virol [Internet]. 2020;92(4):424–32. Available from: http://dx.doi.org/10.1002/jmv.25685
27. Li X, Geng M, Peng Y, Meng L, Lu S. Molecular immune pathogenesis and diagnosis of COVID-19. J Pharm Anal [Internet]. 2020;10(2):102–8. Available from: https://doi.org/10.1016/j.jpha.2020.03.001
28. Wang C, Horby PW, Hayden FG, Gao GF. A novel coronavirus outbreak of global health concern. Lancet. 2020;395(10223):470–3.
29. Soleimani V, Sahebkar A, Hosseinzadeh H. Turmeric (Curcuma longa) and its major constituent (curcumin) as nontoxic and safe substances: Review. Phyther Res. 2018;32(6):985–95.
30. Akbar MU, Rehman K, Zia KM, Qadir MI, Akash MSH, Ibrahim M. Critical review on curcumin as a therapeutic agent: From traditional herbal medicine to an ideal therapeutic agent. Crit Rev Eukaryot Gene Expr. 2018;28(1):17–24.
31. Fan Z, Yao J, Li Y, Hu X, Shao H, Tian X. Anti-inflammatory and antioxidant effects of curcumin on acute lung injury in a rodent model of intestinal ischemia reperfusion by inhibiting the pathway of NF-Kb. Int J Clin Exp Pathol. 2015;8(4):3451–9.
32. Zhu JY, Yang X, Chen Y, Jiang Y, Wang SJ, Li Y, et al. Curcumin Suppresses Lung Cancer Stem Cells via Inhibiting Wnt/β-catenin and Sonic Hedgehog Pathways. Phyther Res. 2017;31(4):680–8.
33. Pillaiyar T, Manickam M, Namasivayam V, Hayashi Y, Jung S-H. An overview of severe acute respiratory syndrome–coronavirus (SARS-CoV) 3CL protease inhibitors: peptidomimetics and small molecule chemotherapy. J Med Chem. 2016;59(14):6595–628.
34. Łoczechin A, Séron K, Barras A, Giovanelli E, Belouzard S, Chen YT, et al. Functional Carbon Quantum Dots as Medical Countermeasures to Human Coronavirus. ACS Appl Mater Interfaces. 2019;11(46):42964–74.
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Published
2023-04-11
How to Cite
PRASETYO, Aizar Vesa; WULANDARI, Putri Ayu; WAHYUNI, Putu Sinta Elix.
Potensi Photodynamic Therapy (PDT) Berbasis Inhalable Curcumin sebagai Modalitas Terapi COVID-19.
Essential: Essence of Scientific Medical Journal, [S.l.], v. 20, n. 2, p. 12-21, apr. 2023.
ISSN 2655-6472.
Available at: <https://ojs.unud.ac.id/index.php/essential/article/view/84933>. Date accessed: 05 nov. 2024.
doi: https://doi.org/10.24843/essential.v20i2.84933.
Section
Artikel Tinjauan Pustaka
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