POTENSI FOTODINAMIK SEBAGAI MODALITAS TERAPI ALTERNATIF NON INVASIF PADA ORAL CANCER STADIUM DINI:

TINJAUAN EFIKASI DAN PROFIL KEAMANAN

  • Timotius William Yusuf Program Studi Pendidikan Dokter Gigi, Fakultas Kedokteran Gigi, Universitas Trisakti, Jakarta Barat, Indonesia
  • Jason Chen Program Studi Pendidikan Dokter Gigi, Fakultas Kedokteran Gigi, Universitas Trisakti, Jakarta Barat, Indonesia
  • Vincentius Mario Yusuf Program Studi Pendidikan Dokter, Fakultas Kedokteran, Universitas Brawijaya, Malang

Abstract

Introduction: Oral cancer is defined as a type of malignancy that occurs in the oral cavity and occupies the top 10 leading causes of cancer worldwide. Oral cancer mortality rate is high with a five-year survival rate of only 50-60%. The current treatment is invasive, risky, with severe complications  that can reduce therapy efficacy and patients’ quality of life. Based on previous studies, photodynamics is a promising alternative therapy for  oral cancer because of its selective non-invasive traits and good clinical results. Methods: This literature review was done based on PICO and determined inclusion criterias. Studies were extracted from “PubMed”, “ScienceDirect”, and “SpringerLink” databases using “boolean operator” search method. Results & Discussion: There were a total of 11 clinical studies that met the inclusion criteria and stated that photodynamic therapy was effective in the treatment of oral cancer. Clinical efficacy is seen from high complete response rates and survival rates accompanied by low recurrence rates. The mechanism underlying its efficacy is photosensitizer excitation triggers the production of reactive oxygen species that lead to the destruction of cancer cells. It was also found that photodynamic exposure can cause shut-down of tumor tissue blood vessels and activation of immune system. The most common side effects are pain, swelling, and photosensitivity. In general, side effects found are not fatal, can be controlled and do not cause lasting functional or aesthetic impacts. Conclusion: Photodynamic is effective as a non-invasive therapy modality in oral cancer with good clinical efficacy and safety profile.

Downloads

Download data is not yet available.

References

1. Rivera C. Essentials of oral cancer. International journal of clinical and experimental pathology 2015;8(9):11884- 94.
2. Minić I, Pejčić A. Oral Cancer: Incidence and Management. J Oral Cancer Res. 2018;2(1):23.
3. International Agency for Research on Cancer. Indonesia-Global Cancer Observatory. Globocan 2020. 2021;858:1-2.
4. Speight PM, Farthing PM. The pathology of oral cancer. British dental journal. 2018 Nov;225(9):841.
5. Golusiński W, Kubiak A, Trojanowski M, Korytowska A, Pietrysiak A, Manasterski J, Pychyński T, Golusiński P, Majchrzak E, Sówka M, Szewczyk M. National Programme for Prevention and Early Detection of Head and Neck Cancer. Otolaryngologia polska= The Polish otolaryngology. 2015 Jan 1;69(4):7-12.
6. Kumar M, Nanavati R, Modi TG, Dobariya C. Oral cancer: Etiology and risk factors: A review. Journal of cancer research and therapeutics. 2016 Apr 1;12(2):458-63
7. Ikeda H, Ohba S, Egashira K, Asahina I. The effect of photodynamic therapy with talaporfin sodium, a second-generation photosensitizer, on oral squamous cell carcinoma: A series of eight cases. Photodiagnosis and photodynamic therapy. 2018 Mar 1;21:176-80
8. Wong TS, Wiesenfeld D. Oral cancer. Australian dental journal. 2018 Mar;63:S91-9.
9. Shanti RM, O'Malley Jr BW. Surgical Management of Oral Cancer. Dental Clinics of North America. 2017 Oct 16;62(1):77-86.
10. Ikeda H, Tobita T, Ohba S, Uehara M, Asahina I. Treatment outcome of Photofrin-based photodynamic therapy for T1 and T2 oral squamous cell carcinoma and dysplasia. Photodiagnosis and photodynamic therapy. 2013 Sep 1;10(3):229-35.
11. Liu YQ, Wang XL, He DH, Cheng YX. Protection against chemotherapy-and radiotherapy-induced side effects: A review based on the mechanisms and therapeutic opportunities of phytochemicals. Phytomedicine. 2020 Oct 31:153402
12. Jerjes W, Upile T, Hamdoon Z, Mosse CA, Akram S, Hopper C. Photodynamic therapy outcome for oral dysplasia. Lasers in surgery and medicine. 2011 Mar;43(3):192-9.
13. Karakullukcu B, van Oudenaarde K, Copper MP, Klop WM, van Veen R, Wildeman M, Tan IB. Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis of 170 patients. European Archives of Oto-Rhino-Laryngology. 2011 Feb;268(2):281-8.
14. Karakullukcu B, Nyst HJ, van Veen RL, Hoebers FJ, Hamming–Vrieze O, Witjes MJ, de Visscher SA, Burlage FR, Levendag PC, Sterenborg HJ, Tan IB. mTHPC mediated interstitial photodynamic therapy of recurrent nonmetastatic base of tongue cancers: Development of a new method. Head & neck. 2012 Nov;34(11):1597-606.
15. de Visscher SA, Melchers LJ, Dijkstra PU, Karakullukcu B, Tan IB, Hopper C, Roodenburg JL, Witjes MJ. mTHPC-mediated photodynamic therapy of early stage oral squamous cell carcinoma: a comparison to surgical treatment. Annals of surgical oncology. 2013 Sep;20(9):3076-82.
16. Jerjes W, Upile T, Hamdoon Z, Alexander Mosse C, Morcos M, Hopper C. Photodynamic therapy outcome for T1/T2 N0 oral squamous cell carcinoma. Lasers in surgery and medicine. 2011 Aug;43(6):463-9.
17. Karakullukcu B, Stoker SD, Wildeman AP, Copper MP, Wildeman MA, Tan IB. A matched cohort comparison of mTHPC-mediated photodynamic therapy and trans-oral surgery of early stage oral cavity squamous cell cancer. European Archives of Oto-Rhino-Laryngology. 2013 Mar;270(3):1093-7.
18. Durbec M, Cosmidis A, Fuchsmann C, Ramade A, Céruse P. Efficacy and safety of photodynamic therapy with temoporfin in curative treatment of recurrent carcinoma of the oral cavity and oropharynx. European Archives of Oto-Rhino-Laryngology. 2013 Mar;270(4):1433-9.
19. Toratani S, Tani R, Kanda T, Koizumi K, Yoshioka Y, Okamoto T. Photodynamic therapy using Photofrin and excimer dye laser treatment for superficial oral squamous cell carcinomas with long-term follow up. Photodiagnosis and photodynamic therapy. 2016 Jun 1;14:104-10.
20. Rigual N, Shafirstein G, Cooper MT, Baumann H, Bellnier DA, Sunar U, Tracy EC, Rohrbach DJ, Wilding G, Tan W, Sullivan M. Photodynamic therapy with 3-(1′-hexyloxyethyl) pyropheophorbide a for cancer of the oral cavity. Clinical Cancer Research. 2013 Dec 1;19(23):6605-13.
21. Agostinis P, Berg K, Cengel KA, Foster TH, Girotti AW, Gollnick SO, Hahn SM, Hamblin MR, Juzeniene A, Kessel D, Korbelik M. Photodynamic therapy of cancer: an update. CA: a cancer journal for clinicians. 2011 Jul;61(4):250-81.
22. Lin J, Ni G, Ding T, Lei S, Zhong L, Liu N, Pan K, Chen T, Zeng X, Xu H, Li T. Photodynamic Therapy for Oral Squamous Cell Carcinoma: A Systematic Review and Meta-Analysis. International Journal of Photoenergy. 2021 Feb 16;2021.
23. Sai DL, Lee J, Nguyen DL, Kim YP. Tailoring photosensitive ROS for advanced photodynamic therapy. Experimental & Molecular Medicine. 2021 Apr;53(4):495-504.
24. dos Santos AF, de Almeida DR, Terra LF, Baptista MS, Labriola L. Photodynamic therapy in cancer treatment-an update review. Journal of cancer metastasis and treatment. 2019 Mar 29;5.
25. Benov L. Photodynamic therapy: current status and future directions. Medical Principles and Practice. 2015;24(Suppl. 1):14-28.
26. Hamblin MR. Upconversion in photodynamic therapy: plumbing the depths. Dalton Transactions. 2018;47(26):8571-80
27. Mroz P, Yaroslavsky A, Kharkwal GB, Hamblin MR. Cell death pathways in photodynamic therapy of cancer. Cancers. 2011 Jun;3(2):2516-39.
28. Miki,Y.,Akimoto,J.,Moritake,K.,Hironaka,C.&Fujiwara,Y.Photodynamictherapy using talaporfin sodium induces concentration-dependent pro-grammed necroptosis in human glioblastoma T98G cells.Lasers Med. Sci.30,1739–1745 (2015)
29. Hou YJ, Yang XX, Liu RQ, Zhao D, Guo CX, Zhu AC, Wen MN, Liu Z, Qu GF, Meng HX. Pathological Mechanism of Photodynamic Therapy and Photothermal Therapy Based on Nanoparticles. International Journal of Nanomedicine. 2020;15:6827.
Published
2022-07-20
How to Cite
YUSUF, Timotius William; CHEN, Jason; YUSUF, Vincentius Mario. POTENSI FOTODINAMIK SEBAGAI MODALITAS TERAPI ALTERNATIF NON INVASIF PADA ORAL CANCER STADIUM DINI:. Essential: Essence of Scientific Medical Journal, [S.l.], v. 20, n. 1, p. 43-54, july 2022. ISSN 2655-6472. Available at: <https://ojs.unud.ac.id/index.php/essential/article/view/77763>. Date accessed: 29 sep. 2022. doi: https://doi.org/10.24843/ESTL.2022.v20.i01.p04.