POTENSI miRNA SEBAGAI ALAT DIAGNOSTIK POLIP KOLON: SEBUAH TINJAUAN PUSTAKA

  • Louis Fabio Jonathan Jusni Atma Jaya Catholic University
  • Jason Adiwardhana Atma Jaya Catholic University of Indonesia
  • Maxmillion Budiman Kadharmestan Atma Jaya Catholic University of Indonesia

Abstract

Introduction: Colonic polyps are distinct tissue growth inside the lumen of the colon and an expected precursor for the development of colorectal cancer. Prospective diagnostic modalities such as miRNA might be ideal to evaluate the progression. There are evidence from multiple studies that implied certain dysregulation of miRNA indicates pathologic changes regarding colonic polyps Aim: This review aims to provide overview of the diagnostic capabilities of miRNA in colon polyp and identify gaps of knowledge for further studies Method: A review based on Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) was conducted with the database from Pubmed, Science Direct, and Proquest Result: A total of five studies has reported diagnostic accuracies of miRNA in distinguishing adenoma polyp and normal, adenoma polyp and hyperplastic polyp, sessile serrated adenoma/polyps and hyperplastic polyp, colon polyp and colorectal cancer. Conclusion: miRNAs could be a potential biomarker for colon polyp. Further diagnostics studies, in particular those with clinical values, need to be conducted.

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Published
2022-01-31
How to Cite
JUSNI, Louis Fabio Jonathan; ADIWARDHANA, Jason; KADHARMESTAN, Maxmillion Budiman. POTENSI miRNA SEBAGAI ALAT DIAGNOSTIK POLIP KOLON: SEBUAH TINJAUAN PUSTAKA. Essential: Essence of Scientific Medical Journal, [S.l.], v. 19, n. 2, p. 38-46, jan. 2022. ISSN 2655-6472. Available at: <https://ojs.unud.ac.id/index.php/essential/article/view/68819>. Date accessed: 27 june 2022. doi: https://doi.org/10.24843/ESTL.2021.v19.i02.p07.