Potensi Micro RNA (MiRNA) 499 sebagai Modalitas Multifungsi dan Mutakhir dalam Deteksi Dini Infark Miokard Akut
Abstract
ABSTRAK
PENDAHULUAN: infark miokard akut merupakan keadaan rusaknya kardiomiosit karena iskemia akibat dari penyumbatan pada arteri coroner. Menjadi salah satu penyebab utama kematian di dunia, mebutuhkan biomarker yang efektif dan akurat untuk mendiagnosis sehingga mengurangi jumlah kematian dari infark miokard akut. PEMBAHASAN: MicroRNA (miRNA) adalah molekul RNA noncoding, yang terdiri dari 20-25 nukleotida. Salah satunya adalah miRNA-499 yang telah dikenal sebagai miR spesifik pada kerusakan otot jantung dan juga memiliki sensitivitas 78%, spesifisitas 82%, dan AUC 91% dan dapat mendeteksi infark miokard akut dalam waktu kurang dari 1 jam. Hal ini menunjukkan bahwa miRNA-499 memiliki potensi dalam pengelolaan infark miokard akut. SIMPULAN: MIRNA-499 memiliki potensi untuk mendiagnosis infark miokard akut.
Kata Kunci: Infark miokard akut, miRNA, miRNA-499
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References
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2. Xiao J, Shen B, Li J, Lv D, Zhao Y, Wang F, Xu J. Serum microRNA-499 and microRNA208a as biomarkers of acute myocardial infarction. Int J Clin Exp Med. 2014;7(1):136-141.
3. Xin Y, Yang C, Han Z. Circulating miRNA-499 as a potential biomarker for acute myocardial infarction. Ann Transl Med. 2016 March 10;4(7):135.
4. Burke A. P. Pathology of Acute Myocardial Infarction. 2015. Available from : http://emedicine.medscape.com/ (Accessed 30 Agustus 2017).
5. Panjaitan, H. P. B., Billy, M., Kevin, J. Cardiostem: Inovasi Amniotic Fluid Stem Cell Termodifikasi Gen VEGF (Vascular Endothellial Growth Factor) dengan Carrier chitosan Hydrogel Sebagai TerapiRegeneratif Infark Miokard. Essence of Scientific Medical Journal. 2015;12(1):9.
6. Kumar, V., Abbas, A. K., Aster, J. C. Robbins basic pathology. 9th ed. Philadelphia, PA: Elsevier Saunders; 2013. 3779p.
7. White H. D., Chew D. P. Acute Myocardial Infarction. Lancet. 2008;372:570-84.
8. Tanto C, Liwang F, Hanifati S, Pradipta EA. Kapita selekta kedokteran: essential of medicine. Edisi ke-4. Jakarta: Media Aesculapis; 2014.
9. Takhshid MA, Kojuri J, Tabei SMB, Tavasouli AR, Heidary S, Tabandeh M. Early Diagnosis of Acute Coronary Syndrome with Sensitive Troponin I and Ischemic Modified Albumin. Iranian Cardiovascular Research Journal 2010;4(4):144-151.
10. Fichtlscherer S, Zeiher AM, Dimmeler S. Circulating MicroRNAs Biomarkers or Mediators of Cardivascular Diseas?. Arterioscler Thromb Vasc Biol. 2011;31:2383-2390.
11. Oliveri F, Antonicelli R, Lorenzi M, D’Alessandra Y, Lazzarani R, Santini G, et al. Dignostic potential of circulating miRNA499-5p in elderly patients with acute non ST-elevation myocardial infarction. International Journal of Cardiology 2013;167:531-536.
12. Adachi T, Nakanishi M, Otsuka Y, et al. Plasma microRNA 499 as a biomarker of acute miocardial infraction. Clin Chem 2010;56:1183-1183.
13. Bahari F, Barus D, Suhardi D, Prakoso R. Cardiotube: alat deteksi micrna-208 dan microrna-499 dengan teknik sandwich elisa terbarukan sebagai modalitas diagnosis PJK di layanan primer. Essence of Scientific Medical Journal 2016;14:27-35.
14. Cheng C, Wang Q, You W, et al. MiRNAs as biomarkers of myocardial infraction: a metaanalysis. PloS One 2014;9:e88566.
15. Gidlof O, Smith JG, Miyazu K, et al. Circulating cardioencriched microRNAs are associated with long-term prognosis following myocardial infraction. BMC Cardiovasc Disord 2013;13:25.
16. Chen X, Zhang L, Su T, Li H, Huang Q, Wu D, Yang C, Han Z. Kinetics of plasma microRNA-499 expression in acute myocardial infarction. J Thorac Dis. 2015;7(5):890-896.
17. Devaux Y, Vausort M, Goretti E, et al. Use of circulating microRNAs to diagnose acute myocardial infarction. Clin Chem 2012;58:559-67.
18. Płocka MO, Gurda D, Wyszomirska AF, Smolarek I dan Wyszko E. Circulating microRNAs in Cardiovascular Diseases. Acta Biochimica Polonica. 2016;63(4):725–729.
19. Min P-K, Chan SY (2015) The biology of circulating microRNA in cardiovascular disease. Eur J Clin Invest 45: 860–874.
20. Zhang L, Chen X, Su T, Li H, Huang Q, Wu D, Yang C, Han Z. Circulating miRNA-499 are novel and sensitive biomarker of acute myocardial infarction. J Thorac Dis. 2015;7(3):303-8.
Published
2020-08-01
How to Cite
SUKSMARINI, Pramita Widya; DEWI, Putu Mela; OKTAVIAN, Hearty Indah.
Potensi Micro RNA (MiRNA) 499 sebagai Modalitas Multifungsi dan Mutakhir dalam Deteksi Dini Infark Miokard Akut.
Essential: Essence of Scientific Medical Journal, [S.l.], v. 18, n. 1, p. 27-31, aug. 2020.
ISSN 2655-6472.
Available at: <https://ojs.unud.ac.id/index.php/essential/article/view/54002>. Date accessed: 24 apr. 2024.
Section
Artikel Tinjauan Pustaka
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