TRANSMISSIBLE VENEREAL TUMOR SURGERY AND CHEMOTHERAPY IN A FEMALE LOCAL DOG WITH A HISTORY OF MACROCYTIC-HYPOCHROMIC ANEMIA
Abstract
Canine transmissible venereal tumor (CTVT) is a malignant tumor of the genital organs that is transmitted to dogs through implantation of tumor cells in the mucous membranes during mating, licking, biting, fighting, or various forms of direct contact. The case animal is a 1.5 years old female local dog with a body weight of 10.45 kg with a complaint of a lump in the vaginal area for the last 2 months and blood dripping from her vagina. Based on anamnesis, physical examination, and supporting examinations including hematological examination, it was found that the case dog had hypochromic macrocytic anemia, on cytology examination found the presence of intranuclear and intracytoplasmic CTVT vacuoles, and histopathological examination revealed homogeneous lymphoblasts and lymphocytes, mitotic cells, and connective tissue stroma, so the case dog was diagnosed with Canine Transmissible Venereal Tumor. Treatment for CTVT is done through surgery and chemotherapy. Preoperatively given atropine sulfate premedication at a dose of 0.02 mg/kg BW subcutaneously, and anesthetized using a combination of ketamine-xylazine at a dose of 2 mg/kg BW and 12 mg/kg BW intravenously, respectively. Surgery is performed by excision of the tumor mass in the vaginal area. Postoperatively, cefotaxime at a dose of 25 mg/kg BW was administered intravenously twice a day and the analgesic tolfenamic acid at a dose of 4 mg/kg BW was administered intramuscularly once a day. Followed on the second day by administering the drug orally, namely the antibiotic cefixime at a dose of 5 mg/kg BW given twice a day for five days, meloxicam at a dose of 0.1 mg/kg BW given once a day for five days. Sangobion capsules are given once a day for five days. Dogs were given chemotherapy drug vincristin sulfate at a dose of 0.025 mg/kg BW intravenously on the 4th and 11th postoperative days. On the fourth postoperative day, the vulva did not experience swelling, the dog was actively playing, normal urination, eating and drinking well, no disturbances occurred, so the case dog was declared to have developed well after surgery.
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Ajayi OL, Oluwabi M, Ajadi RA, Antia RE, Omotainse SO, Jubril AJ, Adebayo OO, Makinde AF. 2018. Cytomorphological, histopathological and immunohistochemical observations on the histiocytic origin of canine transmissible venereal tumour. Sokoto J. Vet. Sci. 16(2): 10-20.
Andari CM, Kardena IM, Puja IK. 2016. A survey on cases of canine transmissible venereal tumor (TVT) in kintamani dog. Vet. Sci. Med. J. 4(1): 23-25.
Athar M, Suhail A, Muhammad G, Shakoor A, Azim F. 2001. Clinico-therapeutic studies on canine transmissible venereal tumour. Pakistan Vet. J. 21(1): 39-43.
Bastan AD, Baki A, Cengiz M. 2008. Uterine and ovarian metastasis of transmissible venereal tumour in a bitch. Turkey J. Vet. Anim. Sci. 32(1): 65–66.
Berata IK, Winaya IBO, Mirah AAA, Adnyana IBW, Kardena IM. 2011. Patologi veteriner umum. Bahan Ajar. Denpasar. Fakultas Kedokteran Hewan. Universitas Udayana.
Brock KA. 2001. Preanaesthetic use of atropine in small animals. Australian Vet. J. 79(1): 24-25.
Das AK, Das U, Das D, Sengupta J .1990. Histopathologial study of canine transmissible venereal tumor. Indian Vet. J. 67(5): 473-474.
Das D, Kumthekar S, Manikantha KGV, Achary KH. 2020. Sticker tumour (Transmissible venereal tumour) in dog. The Pharm. Innov. J. 9(9): 126-130.
Eze CA, Anyanwu HC, Kene ROC. 2007. Review of canine transmissible venereal tumour (TVT) in dogs. Nigerian Vet. J. 28(1): 54-70.
Ganguly B, Das U, Das AK. 2013. Canine transmissible venereal tumour: a review. Vet. Comparative Oncol. 14(1): 1-12.
Hahn KA. 1990. Vincristine sulfate as single-agent chemotherapy in a dog and a cat with malignant neoplasms. J. American Vet. Med. Assoc. 197: 504-506.
Hsiao YW, Liao KW, Hung SW, Chu RM. 2002. Effect of tumor infiltrating lymphocyte on the expression of MHC molecules in canine transmissible venereal tumor cells. Vet. Immunol. Immunopathol. 87: 19–28.
Hiblu MA, Khabuli NM, Gaja AO. 2019. Canine transmissible venereal tumor: First report of three clinical cases from Tripoli, Libya. Open Vet. J. 9(2): 103-105.
Hijrineli, Soenarjo, Harahap MS. 2013. Pengaruh asam traneksamat pada profil koagulasi pasien yang mendapatkan ketorolak. J. Anestesiol. Indon. 5(3): 183-192.
Islam MS, Das S, Alim MA, Uddin MM, Kabir MHB, Islam MT, Ghosh KK, Masuduzzaman M. 2014. Progressive type of canine transmissible venereal tumor (CTVT) in a male stray dog: a case report. Res. J. Vet. Pract. 2(4): 70-72.
Jones LM, Booth NH, McDonald LE. 1997. Veterinary pharmacology and therapeutics. Oxford and IBH Pub. Co. New Delhi. Pp. 292- 365.
Kucukbekir CN, Ucmak ZG, Tek G. 2021. Canine transmissible venereal tumor: etiology, diagnosis and treatment. J. Istanbul Vet. Sci. 5(1): 57-65.
Kumar K, Jha AK, Ray K, Gautam AK, Singh D. Diagnosis of Tvt with cell cytology and efficacy of treatment with vincristine sulfate in non- descriptive indian canine breeds. 2020. Indian Journal of Animal Research (): 1-4.
Laksmi IGA, Gorda IW, Jayawardhita AAG. 2019. Laporan kasus: penanganan venereal sarcoma pada anjing lokal betina dengan pembedahan dan kemoterapi. Indon. Med. Vet. 8(4): 414-423.
Longo DL, Kasper DL, Jameson JL, Fauci AS, Hauser AL, Loscalzo J. 2012. Harrison’s principles of internal medicine.18th ed. United States of America: The McGraw-Hill Companies, Inc.
Mackie EJ, Halfter W, Liverani D. 1988. Induction of tenascin in wound healing. J. Cell Biol. 107: 2757-2767.
Mascarenhas MB, Peixoto PV, Regina RR, Elise MY, Samay ZRC, Driemeier D, Sonne L, Franca TN. 2014. Immunohistochemical study of genital and extragenital forms of canine transmissible venereal tumor in Brazil. Pesq. Vet. Bras. 34(3): 250-254.
Mitaart D, Hatibie M, Noersasongko D. 2017. Perbandingan penyembuhan luka insisi menggunakan pisau bedah dan pisau elektrokauter dinilai dengan vancouver scar score pada operasi luka bersih. J. Biomed. 9(3): 191-197.
Nasrudin F, Kardena M, Supartika KE. 2014. Indeks mitosis venereal sarcoma pada anjing lokal di Denpasar. Indon. Med. Vet. 3(4): 334-343.
Plumb DC. 2008. Plumb’s veterinary drug handbook 6th edition. The IOWA.
Pramono WB, Leksana E, Satoto HH. 2016. Pengaruh pemberian ropivakain infiltrasi terhadap tampilan kolagen di sekitar luka insisi pada tikus wistar. J. Anestesiol. Indon. 8(1): 1-10.
Regmi S, Mahato P, Devkota I, Neupane RP, Khulal A, Tiwary AK. 2020. A case report on canine transmissible venereal tumor. J. Zool. Res. 2(2): 11-14.
Rocha NS, Tremori TM, Carneiro JAM. 2014. Fine needle aspiration cytology in the diagnosis of canine cutaneous transmissible venereal tumor-case report. Open J. Vet. Med. 4: 204-209.
Stockham SL, Scott MA. 2008. Fundamentals of veterinary clinical pathology. 2nd Edition, Blackwell Publishing, Ames, 61-64.
Sudisma IGN, Pemayun IGAGP, Jayawarditha AAG, Gorda IW. 2006. Ilmu bedah veteriner dan teknik operasi. Pelawa Sari. Denpasar.
Wintoko R, Yadika AND. 2020. Manajemen terkini perawatan luka. J. Kes. Universitas Lampung. 4(2): 183-189.
Yudaniayanti IS, Maulana E, Ma’rufl EM, Ma’rufl A. 2010. Profil penggunaan kombinasi ketamin-xylazine dan ketamin-midazolam sebagai anestesi umum terhadap gambaran fisiologis tubuh pada kelinci jantan. Vet. Med. 3(1): 23-30.
